James Wysock^1,*, Jesse Persily^1,*, Angela Tong², Eli Rapoport¹, Ben Zaslavsky¹, Majlinda Tafa¹, Herbert Lepor¹

Canadian Journal of Urology, Vol.31, No.5, pp. 11986-11991, 2024

Abstract Introduction: Local disease recurrence following focal therapy (FT) for prostate cancer may be due to failure to eradicate focal disease or development of disease in the untreated prostate (in- and out-of-field recurrences). Several studies suggest in-field contrast enhancement (CE) on post treatment multi-parametric (mp) MRI between 6-12 months following FT indicates residual disease. The present study assesses the incidence and oncologic implications of early CE observed following primary partial gland cryoablation (PPGCA).
Material and methods: The surveillance protocol for men enrolled in our prospective outcomes study following PPGCA included mpMRI at 6-12 months, 2 years, 3.5 years,… More >

Fabrizio Drago^*, Irma Battipaglia, Pietro Paolo Tamborrino, Luigina Porco, Camilla Calvieri, Mario Salvatore Russo, Vincenzo Pazzano, Romolo Remoli, Massimo Stefano Silvetti

Congenital Heart Disease, Vol.16, No.6, pp. 561-572, 2021, DOI:10.32604/CHD.2021.016623 - 08 July 2021

Abstract Background: Cryoablation of accessory pathways (APs) is effective and very safe in children, as previously reported by our group. The aim of this retrospective study was to evaluate the current efficacy of 3D non-fluoroscopic cryoablation of right sided APs in children, comparing results obtained with the Ensite Velocity^TM and the more recent Ensite Precision^TM 3D mapping systems. Methods and Results: From January 2016 to December 2019, 102 pediatric patients [mean age 12.5 ± 2.8, 62 males (61% of total cohort)] with right APs underwent 3D non-fluoroscopic transcatheter cryoablation at our Institution. Fifteen (14.7%) patients had previously undergone catheter… More >

Rodrigo Donalisio da Silva, Paulo Jaworski, Diedra Gustafson, Leticia Nogueira, Wilson Molina, Fernando J. Kim

Canadian Journal of Urology, Vol.21, No.2, pp. 7251-7254, 2014

Abstract Prostate cryoablation (PCry) is a well-established minimally invasive therapy for the treatment of prostate cancer. Unfortunately, PCry still carries the stigma of a high rate recto-urethral fistula procedure but with the advent of argon/helium gas technology, urethral warmer and high quality transrectal ultrasound imaging, complications decreased and efficacy increased. The Denver Health Medical Center’s technique in prostate cryoablation is described as follows. More >

Fernando J. Kim^1,2, Priya N. Werahera³, David E. Sehrt¹, Diedra Gustafson¹, Rodrigo D. Silva¹, Wilson R. Molina¹

Canadian Journal of Urology, Vol.21, No.3, pp. 7305-7311, 2014

Abstract Introduction: Our safety net hospital offers minimally invasive, traditional open and perineal radical prostatectomies, as well as radiation therapy and medical oncological services when appropriate. Historically, only few African American and Hispanic patients elected surgical procedures due to unknown reasons. Interestingly, after initiation of the prostate cryoablation program (Whole Gland) in 2003 at Denver Health Medical Center (DHMC) we noticed a trend towards cryotherapy in these specific patient populations for the treatment of localized prostate cancer. We analyzed the profile of ethnic minority men evaluated for localized prostate cancer and evaluated the associated factors in the… More >

Tommaso Silvestri¹, Fulvio Stacul², Michele Bertolotto³, Mary Artero⁴, Salvatore Siracusano¹

Canadian Journal of Urology, Vol.21, No.4, pp. 7390-7392, 2014

Abstract In patients who underwent renal transplantation, urinary tract tumors have an incidence of approximately 1.5%-3.3%. We report a rare case of renal cell carcinoma occurring in a transplanted kidney 25 years after the transplant. The lesion was treated by CT-guided percutaneous cryoablation with the ablation of renal lesion. This approach offers more accuracy compared with ultrasonography (US), and it is faster compared to magnetic resonance (MR) guidance. In transplanted kidneys, CT-guided cryoablation seems to be safe. More >

Rodrigo Donalisio da Silva¹, Paulo Jaworski¹, Diedra Gustafson¹, Leticia Nogueira¹, Francis Kang², Wilson Molina^1,2, Fernando J. Kim^1,2,3

Canadian Journal of Urology, Vol.21, No.6, pp. 7574-7577, 2014

Abstract Recently, diagnoses of small renal masses and renal cell carcinoma (RCC) have increased due to the widespread use of radiographic imaging studies (computerized tomography, magnetic resonance imaging). It appears that biological factors such as obesity and tobacco use increase the risk for RCC. In general, small malignant renal masses are low stage and low grade. The management of asymptomatic renal masses is a surgical challenge since overtreatment of benign masses is not desired, especially for patients with complex medical comorbidities, elderly patients, and those with impaired renal function. Partial nephrectomy has been considered the gold More >

Matthew A. Morgan¹, Nathan R. Roberts², Laura A. Pino¹, Edouard J. Trabulsi^2,3, Daniel B. Brown^1,3, Leonard G. Gomella^2,3, Costas D. Lallas^2,3

Canadian Journal of Urology, Vol.20, No.5, pp. 6933-6937, 2013

Abstract Introduction: Partial nephrectomy has a 3%-4% incidence of local treatment failure. This study is to present a series of percutaneous cryoablation for locally recurrent renal cell carcinoma after partial nephrectomy.
Materials and methods: Five consecutive patients were referred to our quaternary center’s multidisciplinary Small Renal Mass (SRM) Center for assessment after failure of partial nephrectomy. Tumor size and location was noted. CT-guided cryoablation was performed using an argon/helium-based system (Healthtronics, Austin, Texas, USA). Patients were admitted overnight for observation. Patients were followed with serial imaging, laboratory tests and examination at our SRM Center. Tumor size, location, and… More >

David A. Rebuck, Robert B. Nadler, Kent T. Perry

Canadian Journal of Urology, Vol.19, No.1, pp. 6094-6099, 2012

Abstract Introduction: To assess the technical feasibility and safety of trajectory image-guided percutaneous renal cryoablation in a porcine model.
Materials and methods: Six pigs (12 kidneys) were utilized. Only the posterior and lateral regions of the kidneys were considered. A bone-anchored dynamic reference frame (DRF) was inserted into the iliac crest and the O-Arm and StealthStation TREON System (OASSTS, Medtronic, CO, USA) was used to acquire 3-dimensional (3D) imaging of the kidneys. A hand-held pointing device was crafted from a cryoablation needle (Galil Medical, MN, USA) and an optical reference frame. The hand-held pointer/cryoablation needle ("cryoprobe") was then… More >

Christopher J. Long¹, Daniel J. Canter², Marc C. Smaldone², Tianyu Li³, Jay Simhan¹, Boris Rozenfeld², Ervin Teper², David Y. T. Chen², Richard E. Greenberg², Rosalia Viterbo², Robert G. Uzzo², Alexander Kutikov²

Canadian Journal of Urology, Vol.19, No.5, pp. 6417-6422, 2012

Abstract Introduction: To characterize the relationship between tumor location and choice in selecting surgical cryoablation (SCA) versus percutaneous cryoablation (PCA) for treatment of renal masses.
Materials and methods: MEDLINE search was performed to identify studies in which cryoablation was used as therapy for renal masses. Tumor location was stratified as anterior, posterior, or lateral. Lesions were also described by endophycity (endo-, meso-, or exophytic) and polarity (upper, mid, or lower pole). Treating specialty was stratified as urology, radiology, or both. Comorbidity reporting rates were indexed for each manuscript.
Results: Thirty-seven manuscripts included 2344 lesions treated by SCA or PCA… More >

Andrew C. Strine¹, David J. Grignon², Chandru P. Sundaram³

Canadian Journal of Urology, Vol.18, No.4, pp. 5856-5859, 2011

Abstract Ablative therapy has recently emerged as an option for the treatment of small renal masses (SRMs). Benign tumors and indolent renal cell carcinoma (RCC) represent a majority of these masses, although an additional but often unappreciated consideration is upper tract urothelial carcinoma (UC). We report the case of a 74-year-old man with upper tract UC presenting as a SRM without any apparent involvement of the pelvicalyceal system, leading to its inadvertent cryoablation. We also discuss the role of renal biopsy in the management of SRMs undergoing an ablative procedure. More >