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  • Open Access

    REVIEW

    Curcumin in inflammatory bowel diseases: Cellular targets and molecular mechanisms

    AMYLLY SANUELLY DA PAZ MARTINS1,#, MARLA DE CERQUEIRA ALVES2,#, ORLANDO ROBERTO PIMENTEL DE ARAÚJO3, FABIANA OLIVEIRA DOS SANTOS CAMATARI4, MARÍLIA OLIVEIRA FONSECA GOULART1,3,5, FABIANA ANDRÉA MOURA2,6,*

    BIOCELL, Vol.47, No.11, pp. 2547-2566, 2023, DOI:10.32604/biocell.2023.043253

    Abstract

    Curcumin, a natural product, has exhibited promising effects in both animal models and clinical trials, interacting with a multitude of factors linked to Inflammatory Bowel Disease (IBD). These factors encompass cytokines, oxidative stress-associated enzymes, and modulation of the intestinal microbiota. Notably, curcumin has demonstrated therapeutic potential in animal models of colitis, wherein it exerts a negative regulatory influence on pivotal signaling pathways such as PI3/Akt, JAK/STAT, and β-catenin. Moreover, it inhibits the expression of pro-inflammatory enzymes and co-stimulatory molecules (including RANKL, ICAM-1, CD205, CD256, TLR4, among others), while curbing immune cell chemotaxis, thereby attenuating the characteristic neutrophil infiltration observed in… More > Graphic Abstract

    Curcumin in inflammatory bowel diseases: Cellular targets and molecular mechanisms

  • Open Access

    ARTICLE

    A Scalable Interconnection Scheme in Many-Core Systems

    Allam Abumwais*, Mujahed Eleyat

    CMC-Computers, Materials & Continua, Vol.77, No.1, pp. 615-632, 2023, DOI:10.32604/cmc.2023.038810

    Abstract Recent architectures of multi-core systems may have a relatively large number of cores that typically ranges from tens to hundreds; therefore called many-core systems. Such systems require an efficient interconnection network that tries to address two major problems. First, the overhead of power and area cost and its effect on scalability. Second, high access latency is caused by multiple cores’ simultaneous accesses of the same shared module. This paper presents an interconnection scheme called N-conjugate Shuffle Clusters (NCSC) based on multi-core multi-cluster architecture to reduce the overhead of the just mentioned problems. NCSC eliminated the need for router devices and… More >

  • Open Access

    ARTICLE

    Preventing Health Anxiety: The Role of Self-Evaluation, Sense of Coherence, Self-Rated Health and Perceived Social Support

    Sándor Csibi1, Mónika Csibi2,*, József Bognár1

    International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1081-1088, 2023, DOI:10.32604/ijmhp.2023.029390

    Abstract Background: Components of Self, completed with the perceived social support determine the individual differences in the evaluation of a stressor and the behavioral responses toward it, such as health-related anxiety. The study set as a goal the analysis of associations between the components of Self, such as self-evaluation, sense of coherence, perceived social support, and reported health-related anxiety in an adult sample. Methods: 147 adults from the 18–73 age group (mean age 37.5) voluntarily completed the questionnaire through Qualtrics online platform containing the Short Health Anxiety Inventory, Core Self-Evaluation Scale, Social Support Assessing Scale, and one Health Self-Evaluation Item. Results:More >

  • Open Access

    ARTICLE

    A Multilevel Hierarchical Parallel Algorithm for Large-Scale Finite Element Modal Analysis

    Gaoyuan Yu1, Yunfeng Lou2, Hang Dong3, Junjie Li1, Xianlong Jin1,*

    CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 2795-2816, 2023, DOI:10.32604/cmc.2023.037375

    Abstract The strict and high-standard requirements for the safety and stability of major engineering systems make it a tough challenge for large-scale finite element modal analysis. At the same time, realizing the systematic analysis of the entire large structure of these engineering systems is extremely meaningful in practice. This article proposes a multilevel hierarchical parallel algorithm for large-scale finite element modal analysis to reduce the parallel computational efficiency loss when using heterogeneous multicore distributed storage computers in solving large-scale finite element modal analysis. Based on two-level partitioning and four-transformation strategies, the proposed algorithm not only improves the memory access rate through… More >

  • Open Access

    ARTICLE

    Outage Probability Analysis for D2D-Enabled Heterogeneous Cellular Networks with Exclusion Zone: A Stochastic Geometry Approach

    Yulei Wang1, Li Feng1,*, Shumin Yao1,2, Hong Liang1, Haoxu Shi1, Yuqiang Chen3

    CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.1, pp. 639-661, 2024, DOI:10.32604/cmes.2023.029565

    Abstract Interference management is one of the most important issues in the device-to-device (D2D)-enabled heterogeneous cellular networks (HetCNets) due to the coexistence of massive cellular and D2D devices in which D2D devices reuse the cellular spectrum. To alleviate the interference, an efficient interference management way is to set exclusion zones around the cellular receivers. In this paper, we adopt a stochastic geometry approach to analyze the outage probabilities of cellular and D2D users in the D2D-enabled HetCNets. The main difficulties contain three aspects: 1) how to model the location randomness of base stations, cellular and D2D users in practical networks; 2)… More >

  • Open Access

    ARTICLE

    The Impact of Inoculum Preparation Media on Pollutant Removal through Phycoremediation of Agricultural Drainage Water by Desmodesmus sp.

    Asmaa Salah1, Hoda Sany1, Abo El-Khair B. El-Sayed2, Reham M. El-Bahbohy1, Heba I. Mohamed3,*, Ayman Amin1,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2875-2890, 2023, DOI:10.32604/phyton.2023.031064

    Abstract Water is the most essential natural resource for the future development. Agriculture production is extensively water-dependent and a significant polluter of water resources. So, this work investigated the effect of two different preparation media [Bold’s Basal Medium (BBM) and Domiati cheese whey (DCW)] for agricultural drainage water (ADW) remediation. All treatments were incubated for 6 days. According to the results of biomass productivity, specific growth rate, photosynthetic pigments, and biochemical composition, Desmodesmus sp. can grow in drainage water without dilution. The two treatments significantly reduced the concentration of nitrate, phosphate, chemical oxygen demand, and sodium in ADW. Finally, using cheese… More >

  • Open Access

    ARTICLE

    First Report of a Successful Development of Yam Hybrids (Dioscorea alata L.) from Lyophilized and Long-Term Stored Pollens

    Erick Malédon1, Elie Nudol1, Christophe Perrot1, Marie-Claire Gravillon1, Ronan Rivallan2,3, Denis Cornet2, Hâna Chair2,3, Komivi Dossa1,2,3,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2861-2874, 2023, DOI:10.32604/phyton.2023.042397

    Abstract Various biological constraints including erratic and asynchronous flowering between male and female plants hinder successful hybrid development and genetic gains in greater yam breeding programs. Therefore, pollen storage has gained much attention to facilitate artificial pollinations and increase the genetic gains. This 4-year study aimed at developing a practical long-term pollen storage technique for the successful development of yam hybrids. Fresh pollens were collected from two Dioscorea alata males, then lyophilized (two lyophilization treatments were applied), followed by storage at room temperature (24°C–25°C) for 12 months. Moreover, the lyophilized and stored pollens were tested for viability by crossing with four… More >

  • Open Access

    PROCEEDINGS

    Dislocation Climb Driven by Lattice Diffusion and Core Diffusion

    Fengxian Liu1,*, Alan Cocks2, Edmund Tarleton2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.09495

    Abstract Diffusion of material has a crucial influence on dislocation motion, particularly at elevated temperatures. It is generally believed that, in a single crystal, lattice diffusion prevails when the temperature is high and core diffusion dominates at relatively low temperatures. Due to the complexity of modelling the coupling between core and lattice diffusion, a given physical problem is often simplified into two extremes where only one of the two diffusion regimes is considered. However, a quantitative definition of the condition under which each of the diffusion mechanisms is dominant is still lacking. In the present work, we employ a variational principle… More >

  • Open Access

    PROCEEDINGS

    Low-Velocity Impact Response of Sandwich Composite Panels with Shear Stiffening Gel Filled Honeycomb Cores

    Gaojian Lin11,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.3, pp. 1-2, 2023, DOI:10.32604/icces.2023.09075

    Abstract Over decades, sandwich composite panels (SCPs) have been widely used to fabricate lightweight but strong structural components. However, composite sandwich structures are susceptible to impact damage, which may severely reduce the structural stiffness, stability, and load-carrying capacity[1, 2]. In order to enhance the anti-impact capacity of SCPs, a series of novel core structures[3-5] and filling materials[6-8] have been proposed and tested. One of them is the shear thickening fluids (STFs), which mechanical behavior changed from liquid to solid when subjected to high strain rate shear loading[7, 9]. For example, Fu et al.[10] filled the honeycomb cores of Carbon fiber reinforced… More >

  • Open Access

    ARTICLE

    Real-Time Multi Fractal Trust Evaluation Model for Efficient Intrusion Detection in Cloud

    S. Priya1, R. S. Ponmagal2,*

    Intelligent Automation & Soft Computing, Vol.37, No.2, pp. 1895-1907, 2023, DOI:10.32604/iasc.2023.039814

    Abstract Handling service access in a cloud environment has been identified as a critical challenge in the modern internet world due to the increased rate of intrusion attacks. To address such threats towards cloud services, numerous techniques exist that mitigate the service threats according to different metrics. The rule-based approaches are unsuitable for new threats, whereas trust-based systems estimate trust value based on behavior, flow, and other features. However, the methods suffer from mitigating intrusion attacks at a higher rate. This article presents a novel Multi Fractal Trust Evaluation Model (MFTEM) to overcome these deficiencies. The method involves analyzing service growth,… More >

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