Sana Rezig^*, Foued Khoffi, Mounir Jaouadi, Asma Eloudiani, Slah Msahli

Journal of Renewable Materials, Vol.12, No.6, pp. 1071-1086, 2024, DOI:10.32604/jrm.2024.049935

Abstract Plant derived natural fibers have been widely investigated as alternatives to synthetic fibers in reinforcing polymers. Researchers over the years have explored many plant fibers using different extraction processes to study their physical, chemical, and mechanical properties. In this context, the present study relates to the extraction, characterization, and optimization of Typha angustata L. stem fibers. For this purpose, desirability functions and response surface methodology were applied to simultaneously optimize the diameter (D), linear density (LD); yield (Y), lignin fraction (L), and tenacity (T) of Typha stem fibers. Typha stems have been subjected to both alkali (NaOH) and enzymatic… More > Graphic Abstract

Makoto Akiyama^*†, Yoshihiro Sowa^*, Tomoyuki Taniguchi^*, Motoki Watanabe^*, Shingo Yogosawa^‡, Jo Kitawaki^†,Toshiyuki Sakai^*

Oncology Research, Vol.25, No.8, pp. 1245-1252, 2017, DOI:10.3727/096504017X14850164661097

Abstract Ovarian cancer is the most lethal disease among gynecological malignancies. More effective therapy is required to counter high recurrence rates and chemotherapy resistance. We investigated the efficacy and molecular mechanisms of three combined treatments (TCTs)—a novel histone deacetylase (HDAC) inhibitor OBP-801/YM753, 5-fluorouracil (5-FU), and paclitaxel (PTX)—in human ovarian cancer SKOV-3 and OVCAR-3 cells. The inhibition of cell growth was stronger with TCTs than with each single agent and with two combined treatments. The TCTs significantly induce G₂ phase arrest in both cell lines. We then analyzed the molecular mechanisms and found that the TCTs increased the More >