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  • Open Access

    PROCEEDINGS

    Microcarrier Systems for Cell Co-Culture Reveal Cell-Cell Interactions

    Zhanwu Hou1, Linfeng Xu2,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.1, pp. 1-0, 2024, DOI:10.32604/icces.2024.012892

    Abstract The cell-cell interaction between immune cells and tumor cells in the tumor microenvironment plays an important role in the genesis and development of tumors. However, due to the lack of methods to systematically identify the interaction between the two, the specific molecular mechanisms involved are not well understood. The microfluidic platform provides a high-throughput and precise method for studying cell interactions in microreactive systems. However, the traditional platform for studying cell interactions is the closed droplet system, which is easy to cause the consumption of nutrients and the accumulation of wastes, thus interfering with cell… More >

  • Open Access

    ARTICLE

    The anti-neoplastic effects of metformin modulate the acquired phenotype of fibroblast cells in the breast cancer-normal fibroblast co-culture system

    SAMANEH MOSTAFAVI, ZUHAIR MOHAMMAD HASSAN*

    Oncology Research, Vol.32, No.3, pp. 477-487, 2024, DOI:10.32604/or.2023.043926 - 06 February 2024

    Abstract Intracellular communications between breast cancer and fibroblast cells were reported to be involved in cancer proliferation, growth, and therapy resistance. The hallmarks of cancer-fibroblast interactions, consisting of caveolin 1 (Cav1) and mono-carboxylate transporter 4 (MCT4) (metabolic coupling markers), along with IL-6, TGFβ, and lactate secretion, are considered robust biomarkers predicting recurrence and metastasis. In order to promote a novel phenotype in normal fibroblasts, we predicted that breast cancer cells could be able to cause loss of Cav1 and increase of MCT4, as well as elevate IL-6 and TGFβ in nearby normal fibroblasts. We created a… More >

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