Muyi Guo¹, Yan Cai¹, Zhiyong Li^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 49-49, 2019, DOI:10.32604/mcb.2019.05727

Abstract Observational studies have identified angiogenesis from the adventitial vasa vasorum and intraplaque hemorrhage (IPH) as critical factors in atherosclerotic plaque progression and destabilization. Here we propose a mathematical model incorporating intraplaque neovascularization and hemodynamic calculation for the quantitative evaluation of atherosclerotic plaque hemorrhage. An angiogenic microvasculature based on histology of a patient’s carotid plaque is generated by two-dimensional nine-point model of endothelial cell migration. Three key cells (endothelial cells, smooth muscle cells and macrophages) and three key chemicals (vascular endothelial growth factors, extracellular matrix and matrix metalloproteinase) are involved in the intraplaque angiogenesis model, and described by the reaction-diffusion partial… More >

Yi Luo^1,*, Erxiu Shi², Yin Feng², Boyun Guo², Liehui Zhang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.1, pp. 105-122, 2019, DOI:10.32604/cmes.2019.06500

Abstract Development of unconventional tight oil and gas reservoirs such as shale pays presents a huge challenge to the petroleum industry due to the naturally low permeability of shale formations and thus low productivity of oil and gas wells. Shale formations are also vulnerable to the contamination of the water in the drilling and completion fluids, which further reduces reservoir permeability. Although gas-drilling (drilling with gas) has been used to address the issue, several problems such as formation water influx, wellbore collapse, excessive gas volume requirement and hole cleaning in horizontal drilling, still hinder its application. A new technique called gas-lift… More >

Shu Chien^*

Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 163-178, 2019, DOI:10.32604/mcb.2019.07689

Abstract Professor Y.C. Fung has made tremendous impacts on science, engineering and humanity through his research and its applications, by setting the highest standards, through educating many students and their students, and providing his exemplary leadership. He has applied his profound knowledge and elegant analytical methods to the study of biomedical problems with rigor and excellence. He established the foundations of biomechanics in living tissues and organs. Through his vision of the power of “making models” to explain and predict biological phenomena, Dr. Fung opened up new vista for bioengineering, from organs-systems to molecules-genes, and has provided the foundation of research… More >

Wei Huang^∗,†, Qinlian Zhou^†,‡, Jian Gao^‡, R. T. Yen^‡,§,¶

Molecular & Cellular Biomechanics, Vol.8, No.2, pp. 105-122, 2011, DOI:10.3970/mcb.2011.008.105

Abstract A continuum model was introduced to analyze the pressure-flow relationship for steady flow in human pulmonary circulation. The continuum approach was based on the principles of continuum mechanics in conjunction with detailed measurement of vascular geometry, vascular elasticity and blood rheology. The pulmonary arteries and veins were considered as elastic tubes and the "fifth-power law" was used to describe the pressure-flow relationship. For pulmonary capillaries, the "sheet-flow" theory was employed and the pressure-flow relationship was represented by the "fourth-power law". In this paper, the pressure-flow relationship for the whole pulmonary circulation and the longitudinal pressure distribution along the streamlines were… More >

Shile Liang^†, Meghan Hoskins^†, Cheng Dong^‡

Molecular & Cellular Biomechanics, Vol.7, No.2, pp. 77-91, 2010, DOI:10.3970/mcb.2010.007.077

Abstract To complete the metastatic journey, cancer cells have to disseminate through the circulation and extravasate to distal organs. However, the extravasation process, by which tumor cells leave a blood vessel and invade the surrounding tissue from the microcirculation, remains poorly understood at the molecular level. In this study, tumor cell adhesion to the endothelium (EC) and subsequent extravasation were investigated under various flow conditions. Results have shown polymorphonuclear neutrophils (PMNs) facilitate melanoma cell adhesion to the EC and subsequent extravasation by a shear-rate dependent mechanism. Melanoma cell-PMN interactions are mediated by the binding between intercellular adhesion molecule-1 (ICAM-1) on melanoma… More >

Taha Sochi¹

CMES-Computer Modeling in Engineering & Sciences, Vol.99, No.2, pp. 151-168, 2014, DOI:10.3970/cmes.2014.099.151

Abstract In this paper, a pore-scale network modeling method, based on the flow continuity residual in conjunction with a Newton-Raphson non-linear iterative solving technique, is proposed and used to obtain the pressure and flow fields in a network of interconnected distensible ducts representing, for instance, blood vasculature or deformable porous media. A previously derived analytical expression correlating boundary pressures to volumetric flow rate in compliant tubes for a pressure-area constitutive elastic relation has been used to represent the underlying flow model. Comparison to a preceding equivalent method, the one-dimensional Navier-Stokes finite element, was made and the results were analyzed. The advantages… More >

Hui-Fen Guo^1,2, Bin-Gang Xu^1,3, Sheng-Yan Li¹, Chong-Wen Yu²

CMES-Computer Modeling in Engineering & Sciences, Vol.80, No.2, pp. 87-112, 2011, DOI:10.3970/cmes.2011.080.087

Abstract Three-dimensional transient simulation is presented for swirling recirculating flow in a nozzle with a slotted-tube (different grooves) and the effect of the groove number is also investigated. The numerical results on the streamline angles are validated by experimental visualization using the surface oil flow technology. In the downstream center of the injectors, the vortex breakdown experiences a transition from bubble- to spiral- breakdown as time is increased. For all cases under study, as the sizes of two recirculation zones near the injector upstream wall and the step retain almost constant, the spiral breakdown shows a periodic development. The more the… More >

Elsa Báez, Alfredo Nicolás¹

CMES-Computer Modeling in Engineering & Sciences, Vol.41, No.2, pp. 107-130, 2009, DOI:10.3970/cmes.2009.041.107

Abstract The unsteady Navier-Stokes equations in primitive variables that govern viscous incompressible fluid flow are numerically solved by a simple projection method which involves an operator splitting technique of three steps in the time discretization process. The numerical scheme does not involve any iteration, is independent of the spatial dimension, and its costly part relies on the solution of elliptic problems for which very efficient solvers exist regardless of the spatial discretization. The scheme is tested with the well known two-dimensional lid-driven cavity problem at moderate and high Reynolds numbers Re in the range 400 ≤ Re ≤ 15000. For moderate… More >

Zhentao Wang^1,*, Kai Dong, Shuiqing Zhan

FDMP-Fluid Dynamics & Materials Processing, Vol.13, No.4, pp. 221-234, 2017, DOI:10.3970/fdmp.2017.013.221

Abstract We have investigated the unsteady internal flow occurring in an evaporating droplet interacting with a high-temperature atmospheric environment. The Navier-Stokes equations for both the liquid and the gas phases have been solved numerically in the framework of a Volume of Fluid (VOF) method relying on the so-called Continuum Surface Force (CSF) model. A specific kernel able to account for evaporation and related phase change has been incorporated directly in the VOF approach. The temperature distributions within the droplet has been found to be relatively uniform by virtue of the Marangoni flow. The transient evolution of the flow pattern and related… More >