Minhua Wu*1, Xubin Deng†1, Yu Zhong‡1, Li Hu*, Xiujuan Zhang§, Yanqin Liang*, Xiaofang Li¶, Xiaoxia Ye*
Oncology Research, Vol.28, No.3, pp. 299-309, 2020, DOI:10.3727/096504020X15796890809840
Abstract MafF is a member of the basic leucine zipper (bZIP) transcription factor Maf family and is commonly
downregulated in multiple cancers. But the expression and function of MafF in hepatocellular carcinoma
(HCC) remain unclear. In this study, we investigated the relationship between endogenous MafF expression
and HCC progression and explored the regulatory mechanism of MafF expression in HCC. We found that MafF
decreased in HCC tissues and cells. Lentivirus-mediated MafF overexpression inhibited HCC cell proliferation
and induced cell apoptosis. Bioinformatics analysis and luciferase assay identified MafF as a direct target of
miR-224-5p. RNA pull-down assay demonstrated that circular RNA circ-ITCH… More >
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