Qin Peng1, Shaoying Lu1, Shu Chien1, Yingxiao Wang1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 83-83, 2019, DOI:10.32604/mcb.2019.07385
Abstract The dramatic re-organization of chromatin during mitosis is perhaps one of the most fundamental of all cell processes [1,2]. It remains unclear how epigenetic histone modifications, despite their crucial roles in regulating chromatin architectures, are dynamically coordinated with chromatin reorganization in controlling this process. Mechanical cues have also been shown to play important roles in modulating gene expressions and cellular functions [3,4]; however, it is still unclear about the mechanical regulations of epigenetics and chromatin organization. In this study, we have developed and characterized biosensors with high sensitivity and specificity based on fluorescence resonance energy… More >
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