Simon Burg¹, Audrey Laure Céline Grust^1,2,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.068555 - 19 January 2026

Abstract Background: With a total of 1.46 million new cases and 396,792 deaths in 2022, prostate cancer is a major medical challenge around the world. Detecting and treating cancer at earlier, preferably localized stages can significantly increase survival rates. Here, a novel blood-based cancer screening as a pre-test in combination with targeted MRI imaging enabled the early diagnosis of prostate cancer. Case Description: We present the case of a 64-year-old man who participated in a prospective, interventional, multicenter cancer screening study where an immunological biopsy-based technique served as a part of a novel screening technique. This immunology… More >

Andong Cheng^1,2,#, Yiding Chen^1,#, Hao Li¹, Feixiang Yang¹, Junlan Jiang³, Sheng Tai¹, Weiwei Chen⁴, Yu Guan¹, Shuiping Yin^1,*, Jialin Meng^1,2,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.066478 - 19 January 2026

Abstract Background: In clinical practice, approximately 80% of prostate cancer (PC) cases are localized and can achieve favorable outcomes with appropriate treatment. Conversely, some remaining cases exhibit an aggressive phenotype or develop resistance to therapeutic interventions, leading to tumor metastasis and a poorer prognosis. When PC metastasizes to distant sites, the bone remains the predominant location, and brain metastases are regarded as exceedingly rare. Case Description: The current study focused on a rare clinical PC case that presented multiple brain metastases after prostate surgery. The patient was initially diagnosed with PC through prostate biopsy and subsequently underwent More >

Harshdeep Singh^*, Pawan Vasudeva, Thiyagarajan Kalaiselvi Aravind

Canadian Journal of Urology, Vol.32, No.6, pp. 685-689, 2025, DOI:10.32604/cju.2025.064435 - 30 December 2025

Abstract Background: Brunn’s cyst is a seldom encountered etiology in a wide spectrum of causative pathologies producing lower urinary tract symptoms (LUTS) in a young male, causing voiding symptoms, with prompt symptom resolution following surgical management. A diagnostic dilemma may arise, as other bladder neck cystic lesions differ in anatomical location, etiology, and the nature of associated LUTS. Case Description: We report a middle-aged male patient with Brunn’s cyst with a brief description of our management strategies and a review of available literature. Conclusions: Brunn’s cyst is a rare but treatable cause of bladder outlet obstruction in More >

William Daly^*, Daniel Pelzman, P. Dafe Ogagan, Stephen V. Jackman

Canadian Journal of Urology, Vol.32, No.6, pp. 669-672, 2025, DOI:10.32604/cju.2025.063778 - 30 December 2025

Abstract Background: Minor bleeding after prostate biopsy is a relatively common complication, but clinically significant hemorrhage happens rarely. Management of prostatic artery pseudoaneurysm has not been described in the literature. Case Description: In this case, an 84-year-old man presented after prostate biopsy with rectal bleeding and required a massive transfusion. Ultimately, he was found to have a prostatic artery pseudoaneurysm, which to our knowledge is heretofore undescribed after prostate biopsy. Bleeding ultimately stopped spontaneously as the patient deferred angioembolization. He had not recurrent bleeding on follow up but is still deciding on treatment course for newly diagnosed More >

Jordan L. Mendelson^1,*, Jordan Kassab¹, Phillip Westbrook¹, Katie Yang², Anthony Corcoran¹

Canadian Journal of Urology, Vol.32, No.6, pp. 673-676, 2025, DOI:10.32604/cju.2025.063770 - 30 December 2025

Abstract Stereotactic body radiotherapy (SBRT) for prostate cancer is a generally well-tolerated treatment but can rarely lead to complications such as fistula formation. We report a 69-year-old male on maintenance ibrutinib for chronic lymphocytic leukemia who developed a fistula between his bladder and vas deferens in the setting of ascending scrotal infection. Despite his prior history of SBRT, the fistula was successfully treated with minimally invasive measures. A combination of abscess debridement, urinary diversion, and broad-spectrum antibiotics helped to achieve fistula resolution. The unique presentation described herein highlights the importance of early aggressive intervention for source More >

Siddharta Saxena, Vikas Kumar Panwar,^*, Ankur Mittal, Mohammed Taher Mujahid, Mehul Agarwal, Nalin Kumar Srivastav

Canadian Journal of Urology, Vol.32, No.6, pp. 677-683, 2025, DOI:10.32604/cju.2025.063597 - 30 December 2025

Abstract Background: Injuries to the penis resulting from self-inflicted strangulation with various objects are uncommon, yet these injuries are more frequently observed in young adults. Medical literature has identified items such as hair, thread, rubber bands, metallic rings, and vacuum erection devices as tools used for this purpose. These constrictive items impede venous return from the penis, potentially leading to severe complications such as ischemia or necrosis. This case series aims to analyse the clinical presentation, management strategies, and psychological dimensions of self-inflicted penile strangulation through a case series. Case Presentation: We conducted a retrospective analysis of… More >

Khaled Elenizi¹, Abdullah Sharaf Aldeen², Nasser Alotaibi^3,*, Nagy Fagir², Hussien Hado², Mubarak Aldossari²

Congenital Heart Disease, Vol.20, No.5, pp. 539-546, 2025, DOI:10.32604/chd.2025.071226 - 30 November 2025

Abstract Persistent left superior vena cava (PLSVC) is a rare congenital anomaly that may complicate cardiac procedures when associated with a dilated coronary sinus (CS) and conduction disturbances. We report the case of a 27-year-old male with Wilson’s disease who presented with complete heart block. Echocardiography showed biatrial enlargement and severe CS dilation, while contrast-enhanced computed tomography (CT) confirmed PLSVC draining into the CS without a bridging vein. Anatomical constraints prevented cardiac resynchronization therapy, and dual-chamber pacemaker implantation proved technically challenging due to lead placement difficulties. This case highlights the importance of thorough preoperative assessment and More >

Si Qin, Shu Tang, Lijiao Xie, Jianbo Zhu, Jianguo Sun^*

Oncology Research, Vol.33, No.12, pp. 4145-4154, 2025, DOI:10.32604/or.2025.068300 - 27 November 2025

Abstract Background: Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype of primary non-small cell lung cancer (NSCLC), with no established treatment guidelines. We present a case of a young female with PPLELC who achieved a pathological complete response (pCR) in both primary and metastatic lesions after receiving combined immunotherapy and radiotherapy. Case description: We present a 33-year-old female patient with stage IVa (cT2bN0M1b) PPLELC. As a first-line treatment, the patient received seven cycles of nab-paclitaxel combined with toripalimab (a PD-1 inhibitor) and achieved stable disease. This was followed by toripalimab maintenance therapy for nearly 30 months.… More >

Sarbjit Mohapatra^1,*, Nandkumar Madhekar², Sameer Ratkal³, Jaideep Ratkal¹

Canadian Journal of Urology, Vol.32, No.5, pp. 509-513, 2025, DOI:10.32604/cju.2025.063783 - 30 October 2025

Abstract Background: Isolated renal aspergilloma is a rare medical entity posing difficult diagnostic and treatment challenges. Case Description: We document a case of Primary Renal Aspergilloma in a 55-year-old male with diabetes mellitus, hypertension, and chronic liver disease. The individual presented with features of obstructive uropathy due to fungal balls requiring retrograde endoscopic intervention and drainage. The cheesy material retrieved during the procedure was identified as an Aspergilloma on histopathology. Due to far and fewer reports in the medical literature, there have been no standard diagnostic & management strategies, which in turn has resulted in unacceptably high More >

Dimindra Karki^*, Ghizlane Yaakoubi, Beth Edelblute, Ahmed Aboumohamed^*

Canadian Journal of Urology, Vol.32, No.5, pp. 501-507, 2025, DOI:10.32604/cju.2025.063294 - 30 October 2025

Abstract Background: Epithelioid angiomyolipoma (EAML) is an uncommon renal tumor variant with histologic and radiologic features that can mimic renal cell carcinoma (RCC) on imaging due to the paucity of fat compared to the classic AML. EAML may exhibit aggressive behavior, including local invasion, recurrence, and distant metastases to the liver, lungs, and lymph nodes. Although recent reports suggest that up to one-third of EAML cases may behave malignantly, variability in diagnostic criteria and limited case series contribute to uncertainty regarding its true clinical course. Case Description: This case report describes a 19-year-old female presenting with an… More >