Taras Shatylko^1,*, Ruslan Safiullin¹, Safar Gamidov^1,2, Tatiana Ivanets¹, Ramazan Mammaev², Kanan Guluzade², Ilia Rodin³, Gennadiy Sukhikh¹

Canadian Journal of Urology, Vol.32, No.6, pp. 561-568, 2025, DOI:10.32604/cju.2025.064572 - 30 December 2025

Abstract Background: Some patients with prostate cancer have elevated gonadotropin levels. It is unknown, however, whether this condition directly influences carcinogenesis in the prostate. It is also unknown whether any specific hormone levels are useful to predict aggressive disease. The potential role of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in prostate physiology is widely discussed. The study aimed to evaluate whether patients with this endocrine pattern have different outcomes following radical prostatectomy. Methods: This was a prospective cohort study of consecutive patients undergoing robot-assisted radical prostatectomy at the Andrology and Urology Department, National Medical Research… More >

Jiao Li^1,2, Nurhayu Ab Rahman^1,3, Suharni Mohamad¹, Guang Yang⁴, Caixia Zhao^2,*

Oncology Research, Vol.33, No.9, pp. 2263-2278, 2025, DOI:10.32604/or.2025.065911 - 28 August 2025

Abstract Objectives: Checkpoint inhibitors have significantly improved outcomes in a number of malignancies. To determine the most effective course of treatment for head and neck squamous cell carcinoma (HNSCC), this systematic review evaluated the efficacy of several therapeutic approaches based on immune checkpoint inhibitors (ICIs). Methods: A comprehensive evaluation of the literature was conducted, looking at randomized controlled trials (RCTs) that were published in Embase, PubMed, and the Cochrane Central Register of Controlled Trials since database establishment. The risk of bias of the enrolled studies was analyzed using The Review Manager (RevMan) 5.4. Using network meta-analyses… More >

LIZHI WANG¹, HUILIN SUN², GUIZHI YU¹, ZEJING QU¹, YING JI¹, YANPING CUI^1,*

Oncology Research, Vol.33, No.4, pp. 885-894, 2025, DOI:10.32604/or.2024.051586 - 19 March 2025

Abstract Background: Small cell lung cancer (SCLC) is characterized by its aggressive nature and high propensity for brain metastases. This study investigates the clinical efficacy and safety profile of Anlotinib in combination with Stereotactic Radiotherapy (SRT) for treating brain metastases in patients with small cell lung cancer (SCLC). Methods: This research included 98 SCLC brain metastasis patients treated at Chengde Central Hospital from October 2020 to January 2024. The patients were categorized into a combined treatment group (CTG) (n = 45) and a Simple SRT group (SSG)(n = 53). The CTG (58 lesions) received Anlotinib with… More >

Wei Wang^1,2, Lan Li^3,*

Psycho-Oncologie, Vol.18, No.4, pp. 257-269, 2024, DOI:10.32604/po.2024.057004 - 04 December 2024

Abstract This study explores the perspectives and challenges faced by family members providing mental support to cancer patients in Beijing, China. The primary objective is to understand the emotional and practical roles family members undertake and the difficulties they encounter. Utilizing a qualitative research design, data were collected through semi-structured interviews with family caregivers of cancer patients. Thematic analysis revealed several key themes: the dual burden of emotional support and caregiving responsibilities, the impact on daily life and personal well-being, the role and effectiveness of external support systems, perceptions of medical staff support, and the common More >

Jing Li¹, Minghui Li^2,*, Guanghuan Xie³

Psycho-Oncologie, Vol.18, No.4, pp. 249-255, 2024, DOI:10.32604/po.2024.056994 - 04 December 2024

Abstract This study reviews the historical development, current applications, and multifaceted impacts of religious psychological coping on the physical and mental health of cancer patients. As a method for coping with life’s pressures through religious beliefs or activities, religious psychological coping has been proven to alleviate the negative emotions of cancer patients and enhance their spiritual well-being and quality of life (QOL). Research indicates that religious faith can alleviate the physical symptoms of cancer patients, extend survival time, reduce the fear of death, assist in coping with treatment side effects, and improve self-efficacy and overall quality More >

Man Liu¹, Zhuoheng Lv^1,#, Hongjing Wang^2,*, Lu Liu^1,*

Psycho-Oncologie, Vol.18, No.4, pp. 305-316, 2024, DOI:10.32604/po.2024.054098 - 04 December 2024

Abstract Objective: Non-small cell lung cancer (NSCLC) patients often experience significant fear of recurrence. To facilitate precise identification and appropriate management of this fear, this study aimed to compare the efficacy and accuracy of a Backpropagation Neural Network (BPNN) against logistic regression in modeling fear of cancer recurrence prediction. Methods: Data from 596 NSCLC patients, collected between September 2023 and December 2023 at the Cancer Hospital of the Chinese Academy of Medical Sciences, were analyzed. Nine clinically and statistically significant variables, identified via univariate logistic regression, were inputted into both BPNN and logistic regression models developed… More >

Huimin Zheng, Minghui Wang^*, Miao Ye

Psycho-Oncologie, Vol.18, No.3, pp. 169-179, 2024, DOI:10.32604/po.2024.052703 - 12 September 2024

Abstract Background: Although fear of cancer recurrence (FCR) is the most important factor affecting the life quality of young breast cancer patients, and it may be affected by the patient’s personality, marital relationship and communication, there is a lack of research on the relationship between adult attachment, self-disclosure and FCR in patients. This study investigated the current situation of FCR in young breast cancer patients, its correlation with adult attachment and self-disclosure and its influencing factors, in order to predict the impact of adult attachment and self-disclosure of patients to spouse on FCR. Methods: A survey… More >

Xia Sun^1,#, Qin Li^1,#, Yang Li², Wenjun Yan³, Shuai Gong¹, Wenjing Yan^2,*

Psycho-Oncologie, Vol.18, No.3, pp. 233-240, 2024, DOI:10.32604/po.2024.048087 - 12 September 2024

Abstract Colorectal cancer (CRC) poses significant physical and psychological challenges that necessitate an exploration of factors influencing post-traumatic growth (PTG) for patient well-being. This study aims to investigate the effects of positive psychological capital (PsyCap) and perceived stress on mediating the social support-PTG relation among 673 CRC patients. Social support, positive PsyCap, perceived stress, and PTG were assessed through questionnaires. The results indicated a direct prediction effect of social support on PTG (LICI = 0.481, ULCI = 0.644), with the direct effect being 59.5%. Both positive PsyCap and perceived stress exerted a mediating role in the… More >

Nazmiye Yıldırım¹, Perihan Güner^2,*, Figen İnci³

Psycho-Oncologie, Vol.18, No.3, pp. 223-231, 2024, DOI:10.32604/po.2023.045294 - 12 September 2024

Abstract Caring for cancer patients requires both technical and psychosocial nursing skills. The aim of this study was to determine the psychosocial care skill levels of nurses and affecting factors. This multicenter, cross-sectional study was conducted with 1,189 nurses providing direct care to adult cancer patients in 32 hospitals in 12 geographical regions of Turkey. A questionnaire, the Psychosocial Skills Form, and the Professional Quality of Life Scale were used to collect the data. Nurses’ psychosocial skill level was in the range of 2.72 ± 0.98 and 2.47 ± 0.89 out of four points. Communication skills… More >

XUEJIA ZHAI^1,2,3,4,#, JIE LIU^2,3,4,#, JINWEI XIAO^2,3,4, TAO ZHANG^2,3,4, JUN WANG^2,3,4,5, JIANJUN LI^1,*, SHICANG YU^2,3,4,5,*

BIOCELL, Vol.48, No.8, pp. 1223-1239, 2024, DOI:10.32604/biocell.2024.050803 - 02 August 2024

Abstract Background: Protein lactylation is a new way for the “metabolic waste” lactic acid to perform novel functions. Nevertheless, our understanding of the contribution of protein lactylation to both tumor progression and therapeutic interventions remains imited. The construction of a scoring system for lactylation to predict the prognosis of pan-cancer patients and to evaluate the tumor immune microenvironment (TIME) would improve our understanding of the clinical significance of lactylation. Methods: Consensus clustering analysis of lactylation-related genes was used to cluster 177 pancreatic adenocarcinoma (PAAD) patients. Subsequently, a scoring system was developed using the least absolute shrinkage… More >