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  • Open Access

    ARTICLE

    Prognostic Value of Circulating Tumor Cells and Cancer Associated Macrophage-Like Cells in Metastatic Non-Small Cell Lung Cancer Patients: A Retrospective Exploratory Analysis

    Marco Siringo1,2,#,*, Michela De Meo1,#, Alain Jonathan Gelibter3, Chiara Nicolazzo4,5,§, Paola Gazzaniga5,§

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069832 - 19 January 2026

    Abstract Objectives: Although immune checkpoint inhibitors (ICIs) and targeted therapies have reshaped treatment non-small cell lung cancer (NSCLC) paradigms, prognosis remains poor for many patients due to delayed diagnosis and resistance mechanisms. Liquid biopsy offers a minimally invasive approach to monitoring tumor evolution. Among circulating biomarkers, circulating tumor cells (CTCs) and cancer-associated macrophage-like cells (CAM-Ls) may provide complementary prognostic insights. The study aimed to evaluate the prognostic role of CTC and CAM-Ls dynamic in metastatic NSCLC patients. Methods: We retrospectively analyzed 77 patients with metastatic NSCLC who underwent CTC and CAM-L evaluation via the CellSearch® system… More >

  • Open Access

    ARTICLE

    Adverse histological features are more commonly observed in hypergonadotropic prostate cancer patients

    Taras Shatylko1,*, Ruslan Safiullin1, Safar Gamidov1,2, Tatiana Ivanets1, Ramazan Mammaev2, Kanan Guluzade2, Ilia Rodin3, Gennadiy Sukhikh1

    Canadian Journal of Urology, Vol.32, No.6, pp. 561-568, 2025, DOI:10.32604/cju.2025.064572 - 30 December 2025

    Abstract Background: Some patients with prostate cancer have elevated gonadotropin levels. It is unknown, however, whether this condition directly influences carcinogenesis in the prostate. It is also unknown whether any specific hormone levels are useful to predict aggressive disease. The potential role of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in prostate physiology is widely discussed. The study aimed to evaluate whether patients with this endocrine pattern have different outcomes following radical prostatectomy. Methods: This was a prospective cohort study of consecutive patients undergoing robot-assisted radical prostatectomy at the Andrology and Urology Department, National Medical Research… More >

  • Open Access

    REVIEW

    Efficacy of Immune Checkpoint Inhibitors in the Treatment for Head and Neck Cancer Patients: A Systematic Review and Network Meta-Analysis

    Jiao Li1,2, Nurhayu Ab Rahman1,3, Suharni Mohamad1, Guang Yang4, Caixia Zhao2,*

    Oncology Research, Vol.33, No.9, pp. 2263-2278, 2025, DOI:10.32604/or.2025.065911 - 28 August 2025

    Abstract Objectives: Checkpoint inhibitors have significantly improved outcomes in a number of malignancies. To determine the most effective course of treatment for head and neck squamous cell carcinoma (HNSCC), this systematic review evaluated the efficacy of several therapeutic approaches based on immune checkpoint inhibitors (ICIs). Methods: A comprehensive evaluation of the literature was conducted, looking at randomized controlled trials (RCTs) that were published in Embase, PubMed, and the Cochrane Central Register of Controlled Trials since database establishment. The risk of bias of the enrolled studies was analyzed using The Review Manager (RevMan) 5.4. Using network meta-analyses… More >

  • Open Access

    ARTICLE

    Evaluating the efficacy and safety of Anlotinib in conjunction with stereotactic radiosurgery for small cell lung cancer patients with brain metastases

    LIZHI WANG1, HUILIN SUN2, GUIZHI YU1, ZEJING QU1, YING JI1, YANPING CUI1,*

    Oncology Research, Vol.33, No.4, pp. 885-894, 2025, DOI:10.32604/or.2024.051586 - 19 March 2025

    Abstract Background: Small cell lung cancer (SCLC) is characterized by its aggressive nature and high propensity for brain metastases. This study investigates the clinical efficacy and safety profile of Anlotinib in combination with Stereotactic Radiotherapy (SRT) for treating brain metastases in patients with small cell lung cancer (SCLC). Methods: This research included 98 SCLC brain metastasis patients treated at Chengde Central Hospital from October 2020 to January 2024. The patients were categorized into a combined treatment group (CTG) (n = 45) and a Simple SRT group (SSG)(n = 53). The CTG (58 lesions) received Anlotinib with… More >

  • Open Access

    ARTICLE

    Perspectives and Challenges of Family Members in Providing Mental Support to Cancer Patients: A Qualitative Study in Beijing, China

    Wei Wang1,2, Lan Li3,*

    Psycho-Oncologie, Vol.18, No.4, pp. 257-269, 2024, DOI:10.32604/po.2024.057004 - 04 December 2024

    Abstract This study explores the perspectives and challenges faced by family members providing mental support to cancer patients in Beijing, China. The primary objective is to understand the emotional and practical roles family members undertake and the difficulties they encounter. Utilizing a qualitative research design, data were collected through semi-structured interviews with family caregivers of cancer patients. Thematic analysis revealed several key themes: the dual burden of emotional support and caregiving responsibilities, the impact on daily life and personal well-being, the role and effectiveness of external support systems, perceptions of medical staff support, and the common More >

  • Open Access

    REVIEW

    Progress in Research on the Impact of Religious Psychological Coping on the Holistic Well-Being of Cancer Patients and Relevant Factors

    Jing Li1, Minghui Li2,*, Guanghuan Xie3

    Psycho-Oncologie, Vol.18, No.4, pp. 249-255, 2024, DOI:10.32604/po.2024.056994 - 04 December 2024

    Abstract This study reviews the historical development, current applications, and multifaceted impacts of religious psychological coping on the physical and mental health of cancer patients. As a method for coping with life’s pressures through religious beliefs or activities, religious psychological coping has been proven to alleviate the negative emotions of cancer patients and enhance their spiritual well-being and quality of life (QOL). Research indicates that religious faith can alleviate the physical symptoms of cancer patients, extend survival time, reduce the fear of death, assist in coping with treatment side effects, and improve self-efficacy and overall quality More >

  • Open Access

    ARTICLE

    Employing a Backpropagation Neural Network for Predicting Fear of Cancer Recurrence among Non-Small Cell Lung Cancer Patients

    Man Liu1, Zhuoheng Lv1,#, Hongjing Wang2,*, Lu Liu1,*

    Psycho-Oncologie, Vol.18, No.4, pp. 305-316, 2024, DOI:10.32604/po.2024.054098 - 04 December 2024

    Abstract Objective: Non-small cell lung cancer (NSCLC) patients often experience significant fear of recurrence. To facilitate precise identification and appropriate management of this fear, this study aimed to compare the efficacy and accuracy of a Backpropagation Neural Network (BPNN) against logistic regression in modeling fear of cancer recurrence prediction. Methods: Data from 596 NSCLC patients, collected between September 2023 and December 2023 at the Cancer Hospital of the Chinese Academy of Medical Sciences, were analyzed. Nine clinically and statistically significant variables, identified via univariate logistic regression, were inputted into both BPNN and logistic regression models developed… More >

  • Open Access

    ARTICLE

    Research on the Association between Fear of Cancer Recurrence in Young Breast Cancer Patients and Adult Attachment and Self-Disclosure

    Huimin Zheng, Minghui Wang*, Miao Ye

    Psycho-Oncologie, Vol.18, No.3, pp. 169-179, 2024, DOI:10.32604/po.2024.052703 - 12 September 2024

    Abstract Background: Although fear of cancer recurrence (FCR) is the most important factor affecting the life quality of young breast cancer patients, and it may be affected by the patient’s personality, marital relationship and communication, there is a lack of research on the relationship between adult attachment, self-disclosure and FCR in patients. This study investigated the current situation of FCR in young breast cancer patients, its correlation with adult attachment and self-disclosure and its influencing factors, in order to predict the impact of adult attachment and self-disclosure of patients to spouse on FCR. Methods: A survey… More >

  • Open Access

    ARTICLE

    Promoting Post-Traumatic Growth in Colorectal Cancer Patients: Exploring the Role of Social Support through a Chain Mediation Model

    Xia Sun1,#, Qin Li1,#, Yang Li2, Wenjun Yan3, Shuai Gong1, Wenjing Yan2,*

    Psycho-Oncologie, Vol.18, No.3, pp. 233-240, 2024, DOI:10.32604/po.2024.048087 - 12 September 2024

    Abstract Colorectal cancer (CRC) poses significant physical and psychological challenges that necessitate an exploration of factors influencing post-traumatic growth (PTG) for patient well-being. This study aims to investigate the effects of positive psychological capital (PsyCap) and perceived stress on mediating the social support-PTG relation among 673 CRC patients. Social support, positive PsyCap, perceived stress, and PTG were assessed through questionnaires. The results indicated a direct prediction effect of social support on PTG (LICI = 0.481, ULCI = 0.644), with the direct effect being 59.5%. Both positive PsyCap and perceived stress exerted a mediating role in the… More >

  • Open Access

    ARTICLE

    The Level of Psychosocial Skills of Nurses Caring for Cancer Patients and Affecting Factors: Results of a Multicenter Study

    Nazmiye Yıldırım1, Perihan Güner2,*, Figen İnci3

    Psycho-Oncologie, Vol.18, No.3, pp. 223-231, 2024, DOI:10.32604/po.2023.045294 - 12 September 2024

    Abstract Caring for cancer patients requires both technical and psychosocial nursing skills. The aim of this study was to determine the psychosocial care skill levels of nurses and affecting factors. This multicenter, cross-sectional study was conducted with 1,189 nurses providing direct care to adult cancer patients in 32 hospitals in 12 geographical regions of Turkey. A questionnaire, the Psychosocial Skills Form, and the Professional Quality of Life Scale were used to collect the data. Nurses’ psychosocial skill level was in the range of 2.72 ± 0.98 and 2.47 ± 0.89 out of four points. Communication skills… More >

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