Asma Batool¹, Fahad Ahmed¹, Naila Sammar Naz¹, Ayman Altameem², Ateeq Ur Rehman^3,4, Khan Muhammad Adnan^5,*, Ahmad Almogren^6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4129-4152, 2025, DOI:10.32604/cmes.2025.073149 - 23 December 2025

Abstract Early and accurate cancer diagnosis through medical imaging is crucial for guiding treatment and enhancing patient survival. However, many state-of-the-art deep learning (DL) methods remain opaque and lack clinical interpretability. This paper presents an explainable artificial intelligence (XAI) framework that combines a fine-tuned Visual Geometry Group 16-layer network (VGG16) convolutional neural network with layer-wise relevance propagation (LRP) to deliver high-performance classification and transparent decision support. This approach is evaluated on the publicly available Kaggle kidney cancer imaging dataset, which comprises labeled cancerous and non-cancerous kidney scans. The proposed model achieved 98.75% overall accuracy, with precision, More >

Bibhuprasad Sahu¹, Amrutanshu Panigrahi², Abhilash Pati², Ashis Kumar Pati³, Janmejaya Mishra⁴, Naim Ahmad^5,*, Salman Arafath Mohammed⁶, Saurav Mallik^7,8,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.1, pp. 1029-1054, 2025, DOI:10.32604/cmes.2025.069618 - 30 October 2025

Abstract Metaheuristic optimization methods are iterative search processes that aim to efficiently solve complex optimization problems. These basically find the solution space very efficiently, often without utilizing the gradient information, and are inspired by the bio-inspired and socially motivated heuristics. Metaheuristic optimization algorithms are increasingly applied to complex feature selection problems in high-dimensional medical datasets. Among these, Teaching-Learning-Based optimization (TLBO) has proven effective for continuous design tasks by balancing exploration and exploitation phases. However, its binary version (BTLBO) suffers from limited exploitation ability, often converging prematurely or getting trapped in local optima, particularly when applied to… More >

Roseline Oluwaseun Ogundokun^*, Pius Adewale Owolawi, Chunling Tu

CMC-Computers, Materials & Continua, Vol.84, No.3, pp. 4869-4885, 2025, DOI:10.32604/cmc.2025.064944 - 30 July 2025

Abstract Breast cancer is among the leading causes of cancer mortality globally, and its diagnosis through histopathological image analysis is often prone to inter-observer variability and misclassification. Existing machine learning (ML) methods struggle with intra-class heterogeneity and inter-class similarity, necessitating more robust classification models. This study presents an ML classifier ensemble hybrid model for deep feature extraction with deep learning (DL) and Bat Swarm Optimization (BSO) hyperparameter optimization to improve breast cancer histopathology (BCH) image classification. A dataset of 804 Hematoxylin and Eosin (H&E) stained images classified as Benign, in situ, Invasive, and Normal categories (ICIAR2018_BACH_Challenge) has… More >

Siti Ramadhani^1,2, Lestari Handayani², Theam Foo Ng³, Sumayyah Dzulkifly¹, Roziana Ariffin^4,5, Haldi Budiman⁶, Shir Li Wang^1,7,*

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.3, pp. 2711-2765, 2025, DOI:10.32604/cmes.2025.062709 - 30 June 2025

Abstract In recent years, feature selection (FS) optimization of high-dimensional gene expression data has become one of the most promising approaches for cancer prediction and classification. This work reviews FS and classification methods that utilize evolutionary algorithms (EAs) for gene expression profiles in cancer or medical applications based on research motivations, challenges, and recommendations. Relevant studies were retrieved from four major academic databases–IEEE, Scopus, Springer, and ScienceDirect–using the keywords ‘cancer classification’, ‘optimization’, ‘FS’, and ‘gene expression profile’. A total of 67 papers were finally selected with key advancements identified as follows: (1) The majority of papers… More > Graphic Abstract

Veena Dillshad¹, Muhammad Attique Khan^2,*, Muhammad Nazir¹, Jawad Ahmad², Dina Abdulaziz AlHammadi³, Taha Houda², Hee-Chan Cho⁴, Byoungchol Chang^5,*

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 5299-5321, 2025, DOI:10.32604/cmc.2025.063851 - 19 May 2025

Abstract Globally, skin cancer is a prevalent form of malignancy, and its early and accurate diagnosis is critical for patient survival. Clinical evaluation of skin lesions is essential, but several challenges, such as long waiting times and subjective interpretations, make this task difficult. The recent advancement of deep learning in healthcare has shown much success in diagnosing and classifying skin cancer and has assisted dermatologists in clinics. Deep learning improves the speed and precision of skin cancer diagnosis, leading to earlier prediction and treatment. In this work, we proposed a novel deep architecture for skin cancer… More >

Pouyan Razmjouei¹, Elaheh Moharamkhani², Mohamad Hasanvand³, Maryam Daneshfar⁴, Mohammad Shokouhifar^5,*

CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 3855-3880, 2024, DOI:10.32604/cmc.2024.054460 - 12 September 2024

Abstract This study investigates the application of deep learning, ensemble learning, metaheuristic optimization, and image processing techniques for detecting lung and colon cancers, aiming to enhance treatment efficacy and improve survival rates. We introduce a metaheuristic-driven two-stage ensemble deep learning model for efficient lung/colon cancer classification. The diagnosis of lung and colon cancers is attempted using several unique indicators by different versions of deep Convolutional Neural Networks (CNNs) in feature extraction and model constructions, and utilizing the power of various Machine Learning (ML) algorithms for final classification. Specifically, we consider different scenarios consisting of two-class colon… More >

Sannasi Chakravarthy¹, Bharanidharan Nagarajan², Surbhi Bhatia Khan^3,7,*, Vinoth Kumar Venkatesan², Mahesh Thyluru Ramakrishna⁴, Ahlam Al Musharraf⁵, Khursheed Aurungzeb⁶

CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 5029-5045, 2024, DOI:10.32604/cmc.2024.052531 - 12 September 2024

Abstract Breast cancer is a type of cancer responsible for higher mortality rates among women. The cruelty of breast cancer always requires a promising approach for its earlier detection. In light of this, the proposed research leverages the representation ability of pretrained EfficientNet-B0 model and the classification ability of the XGBoost model for the binary classification of breast tumors. In addition, the above transfer learning model is modified in such a way that it will focus more on tumor cells in the input mammogram. Accordingly, the work proposed an EfficientNet-B0 having a Spatial Attention Layer with More >

Sonali Das¹, Saroja Kumar Rout², Sujit Kumar Panda¹, Pradyumna Kumar Mohapatra³, Abdulaziz S. Almazyad⁴, Muhammed Basheer Jasser^5,6,*, Guojiang Xiong⁷, Ali Wagdy Mohamed^8,9

CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.1, pp. 893-916, 2024, DOI:10.32604/cmes.2024.051856 - 20 August 2024

Abstract In blood or bone marrow, leukemia is a form of cancer. A person with leukemia has an expansion of white blood cells (WBCs). It primarily affects children and rarely affects adults. Treatment depends on the type of leukemia and the extent to which cancer has established throughout the body. Identifying leukemia in the initial stage is vital to providing timely patient care. Medical image-analysis-related approaches grant safer, quicker, and less costly solutions while ignoring the difficulties of these invasive processes. It can be simple to generalize Computer vision (CV)-based and image-processing techniques and eradicate human… More >

Madiha Hameed^1,3, Aneela Zameer^1,*, Muhammad Asif Zahoor Raja²

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2131-2164, 2024, DOI:10.32604/cmes.2024.050124 - 08 July 2024

Abstract The International Skin Imaging Collaboration (ISIC) datasets are pivotal resources for researchers in machine learning for medical image analysis, especially in skin cancer detection. These datasets contain tens of thousands of dermoscopic photographs, each accompanied by gold-standard lesion diagnosis metadata. Annual challenges associated with ISIC datasets have spurred significant advancements, with research papers reporting metrics surpassing those of human experts. Skin cancers are categorized into melanoma and non-melanoma types, with melanoma posing a greater threat due to its rapid potential for metastasis if left untreated. This paper aims to address challenges in skin cancer detection… More >

Hala AlShamlan^*, Halah AlMazrua^*

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 675-694, 2024, DOI:10.32604/cmc.2024.048146 - 25 April 2024

Abstract In this study, our aim is to address the problem of gene selection by proposing a hybrid bio-inspired evolutionary algorithm that combines Grey Wolf Optimization (GWO) with Harris Hawks Optimization (HHO) for feature selection. The motivation for utilizing GWO and HHO stems from their bio-inspired nature and their demonstrated success in optimization problems. We aim to leverage the strengths of these algorithms to enhance the effectiveness of feature selection in microarray-based cancer classification. We selected leave-one-out cross-validation (LOOCV) to evaluate the performance of both two widely used classifiers, k-nearest neighbors (KNN) and support vector machine… More >