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  • Open Access

    ARTICLE

    Histological Assessment of Bone Regeneration in the Maxilla with Homologous Bone Graft: A Feasible Option for Maxillary Bone Reconstruction

    Sergio Henrique Gonçalves Motta1, Ana Paula Ramos Soares1, Juliana Campos Hasse Fernandes2, Gustavo Vicentis Oliveira Fernandes2,3,*

    Journal of Renewable Materials, Vol.12, No.1, pp. 131-148, 2024, DOI:10.32604/jrm.2023.043940 - 23 January 2024

    Abstract Bone biomaterials have been increasingly used to reconstruct maxillary atrophic ridges. Thus, the aim of this study was to evaluate bone reconstruction in the maxilla using a homologous cortico-cancellous FFB (lyophilized) graft and verify its reliability. Eight individuals were included from 2014 to 2018. The first surgery was performed to install homologous bone blocks in the maxilla. The period of the second intervention varied between 5 months and 15 days to 11 months (≈7.93 months). The biopsies were taken from the central region of the matured graft during the surgery for implant placement. All patients… More >

  • Open Access

    ARTICLE

    Comparison of Apigenin, Quercetin and Kaempferol Accumulation and Total Flavonoid Content in Leaves, Embryogenic Cultures and Cell Suspension Cultures of Parsley (Petroselinum crispum)

    Laura Isabel Arias-Rodríguez1, Martha Alicia Rodríguez-Mendiola2,*, Carlos Arias-Castro2,*, Federico Antonio Gutiérrez Miceli1, Diana Reséndez Pérez3, María Celina Luján Hidalgo1, Juan José Villalobos Maldonado1, Norma Alejandra Mancilla Margalli2

    Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2807-2823, 2023, DOI:10.32604/phyton.2023.030396 - 15 September 2023

    Abstract In recent years, there has been a growing interest in exploring alternative treatments for bone defects. Bone tissue engineering has turned its attention to plant extracts containing osteogenic flavonoids as potential promoters of bone regeneration. In our study, we specifically investigated the extract of Petroselinum crispum, a plant known for its abundance of osteogenic flavonoids such as apigenin, quercetin, and kaempferol. Our objective was to compare the total flavonoid content (TFC) and their accumulation in different sources. We obtained hydrolyzed aqueous extracts from the leaves of parsley plants (grown for 12 weeks in the field), weekly… More >

  • Open Access

    ARTICLE

    Enhanced osteogenic differentiation of human periodontal ligament stem cells by suberoylanilide hydroxamic acid

    YUNZE XUAN1,#, BIN JIN1,#, SAYAN DEB DUTTA5,#, MENGMENG LIU2, ZAIXIAN SHEN1, XIWEN LIU3, YANG KANGJUAN4,*, LIM KI-TAEK5,*

    BIOCELL, Vol.44, No.3, pp. 389-400, 2020, DOI:10.32604/biocell.2020.09170 - 22 September 2020

    Abstract Periodontitis is a type of chronic inflammation in the gingival tissue caused by infectious bacteria colonizing the surface of the teeth, leading to the destruction of tooth-supporting tissues and loss of alveolar bone. Suberoylanilide hydroxamic acid (SAHA), a class of histone deacetylase (HDAC) inhibitor, has the potential to stimulate osteoblast differentiation by acetylating histone proteins, and thus suppressing the expression of adipogenic and chondrogenic genes. However, the effect of SAHA on the differentiation of human periodontal ligament stem cells (hPDLSCs) is yet to be elucidated. Herein, we investigated the effects of SAHA on in vitro More >

  • Open Access

    ARTICLE

    3D Bio-Plotted Composite Scaffold Made of Collagen Treated Hydroxyapatite-Tricalciumphosphate for Rabbit Tibia Bone Regeneration

    Pranav S. Sapkal1*, Abhaykumar M. Kuthe1, Divya Ganapathy2, Shantanu C. Mathankar3, Sudhanshu Kuthe4

    Molecular & Cellular Biomechanics, Vol.13, No.2, pp. 115-136, 2016, DOI:10.3970/mcb.2016.013.131

    Abstract Biphasic calcium phosphate scaffolds with 20/80 HA/TCP ratio were fabricated using the 3D-Bioplotting system to heal critical size defects in rabbit tibia bone. Four different architectures were printed in a layer by layer fashion with lay down patterns viz. (a) 0°– 90°, (b) 0°– 45°– 90°– 135°, (c) 0°–108°– 216° and (d) 0°– 60°– 120°. After high-temperature sintering scaffolds were coated with collagen and were further characterized by (FTIR) Fourier Transform Infrared Spectroscopy, (SEM) Scanning Electron Microscopy, (XRD) X-Ray diffraction, Porosity analysis and Mechanical testing. Scaffold samples were tested for its ability to induce cytotoxicity… More >

  • Open Access

    ARTICLE

    Wnt Signaling is Essential for Bone Regeneration

    J. B. Kim1, P. Leucht1,2, K. Lam1, C. A. Luppen1, D. ten Berg3, R. Nusse3, J. A. Helms1

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 201-201, 2006, DOI:10.32604/mcb.2006.003.201

    Abstract This article has no abstract. More >

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