Pan Zhang1,2, Chen Zhang1,2, Jiyang Han1,2, Xiru Liu1,2, Qishan Wang3, Hui Yang1,2,4,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 132-132, 2019, DOI:10.32604/mcb.2019.06839
Abstract Research in stem cell biology relies on the knowledge of the cell microenvironment in vivo, known as “stem cell niche”, where stem cells are nurtured by the niche signals. Hematopoietic stem cells (HSCs) are capable of continuously generating and maintaining the body’s full immune and hematopoietic systems. In adult, a pool of hematopoietic cells, including HSCs, primarily reside in the bone marrow (BM) niches that plays critical roles on cell fate. Niche supporting cells, cytokines, extracellular matrix proteins and other biochemical cues associated with HSCs behaviors (quiescence, self-renewal, proliferation, differentiation, mobilization, homing, and apoptosis) has… More >
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