Virna Margarita Martín Giménez¹, SebastiáN GarcíA MenéNdez^2,3, Luiz Gustavo A. Chuffa⁴, Vinicius Augusto SimãO⁴, Russel J. Reiter⁵, Ramaswamy Sharma⁶, Walter Balduini⁷, Carla Gentile⁸, Walter Manucha^2,3,*

BIOCELL, Vol.49, No.12, pp. 2245-2282, 2025, DOI:10.32604/biocell.2025.071830 - 24 December 2025

Abstract Neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) are characterized by progressive neuronal loss, which is closely linked to mitochondrial dysfunction. These pathologies involve a complex interplay of genetics, protein misfolding, and cellular stress, culminating in impaired energy metabolism, an increase in reactive oxygen species (ROS), and defective mitochondrial quality control. The accumulation of damaged mitochondria and dysregulation of pathways such as the Integrated Stress Response (ISR) are central to the pathogenesis of these conditions. This review explores the critical relationship between mitochondrial stress… More >

Jo Van Damme¹, Stijn Van Damme², Soffe Struyf¹, Ghislain Opdenakker³

European Cytokine Network, Vol.36, No.1, pp. 6-14, 2025, DOI:10.1684/ecn.2025.0501

Abstract Since their discovery, chemotactic cytokines or chemokines have been intensively studied for about half a century. Chemokines originate from tissue cells, leukocytes, blood platelets and plasma. Here, we review a number of seminal findings on plasma chemokines within an historical and international context. These aspects include how induction and purification protocols led to the discovery of a new family of mediators, named chemokines, on the basis of protein sequencing; how molecular cloning techniques facilitated discoveries of additional family members on the basis of conserved protein structures; how blood plasma and platelets were used as a More >

Ngoc-Hoang-Quyen Nguyen¹, Thanh-Tung Nguyen², Anh-Cang Phan^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 2435-2456, 2025, DOI:10.32604/cmes.2025.070419 - 26 November 2025

Abstract Blood cell disorders are among the leading causes of serious diseases such as leukemia, anemia, blood clotting disorders, and immune-related conditions. The global incidence of hematological diseases is increasing, affecting both children and adults. In clinical practice, blood smear analysis is still largely performed manually, relying heavily on the experience and expertise of laboratory technicians or hematologists. This manual process introduces risks of diagnostic errors, especially in cases with rare or morphologically ambiguous cells. The situation is more critical in developing countries, where there is a shortage of specialized medical personnel and limited access to… More > Graphic Abstract

Lihao Zhang^1,2, Lin Cao^1,2, Lige Huang^1,2, Jie Wang^1,2, Jiabing Li^2,3,*

Canadian Journal of Urology, Vol.32, No.5, pp. 457-468, 2025, DOI:10.32604/cju.2025.067364 - 30 October 2025

Abstract Background: Studies have indicated an association between inflammatory factors (IFs) in the blood and the development of bladder cancer (BC). This study aimed to explore the correlation and clinical significance of IFs with the pathological grading of BC. Methods: A retrospective analysis was conducted on the preoperative blood routine results, postoperative pathological findings, and baseline information of 163 patients. Patients were divided into high-grade and low-grade groups based on pathological grading. Group comparisons and logistic regression analyses were performed using R software version 4.1.3 to explore the relationships between IFs and BC pathological grading. Results: The… More >

Sehrish Bibi^1,*, Vincenzo Minutolo², Obaid Ullah Mehmood³, Renato Zona²

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.10, pp. 2473-2493, 2025, DOI:10.32604/fdmp.2025.072470 - 30 October 2025

Abstract Arterial stenosis is a critical condition with increasing prevalence among pediatric patients and young adults, making its investigation highly significant. Despite extensive studies on blood flow dynamics, limited research addresses the combined effects of nanoparticles and arterial curvature on unsteady pulsatile flow through multiple stenoses. This study aims to analyze the influence of nanoparticles on blood flow characteristics in realistic curved arteries with mild to severe overlapped constrictions. Using curvilinear coordinates, the thermal energy and momentum equations for nanoparticle-laden blood were derived, and numerical results were obtained through an explicit finite difference method. Key findings More >

Osama M. Alshehri¹, Ahmad Shaf^2,*, Muhammad Irfan^3,*, Mohammed M. Jalal⁴, Malik A. Altayar⁴, Mohammed H. Abu-Alghayth⁵, Humood Al Shmrany⁶, Tariq Ali⁷, Toufique A. Soomro⁸, Ali G. Alkhathami⁹

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.1, pp. 1165-1196, 2025, DOI:10.32604/cmes.2025.067150 - 31 July 2025

Abstract Background: Accurate classification of normal blood cells is a critical foundation for automated hematological analysis, including the detection of pathological conditions like leukemia. While convolutional neural networks (CNNs) excel in local feature extraction, their ability to capture global contextual relationships in complex cellular morphologies is limited. This study introduces a hybrid CNN-Transformer framework to enhance normal blood cell classification, laying the groundwork for future leukemia diagnostics. Methods: The proposed architecture integrates pre-trained CNNs (ResNet50, EfficientNetB3, InceptionV3, CustomCNN) with Vision Transformer (ViT) layers to combine local and global feature modeling. Four hybrid models were evaluated on… More >

Myoung Cheol Shin¹, Tae-Kyeong Lee², Dae Won Kim³, Joon Ha Park⁴, Moo-Ho Won¹, Choong-Hyun Lee^5,*, Ji Hyeon Ahn^6,*

BIOCELL, Vol.49, No.6, pp. 1071-1083, 2025, DOI:10.32604/biocell.2025.065506 - 24 June 2025

Abstract Background: Astrocyte endfeet (AEF) serves as a key element of the blood-brain barrier and is important for the survival and maintenance of neuronal function. However, the immunohistochemical and ultrastructural changes of AEF in the CA1 and CA3 areas of the hippocampus over time following cerebral ischemia-reperfusion (IR) injury have not been well elucidated. Objectives: We investigated chronological changes in AEF in the gerbil hippocampal CA1 area from 3 h to 10 days following transient forebrain ischemia (TFI), and examined their association with neuronal death and tissue repair following IR injury. Changes in the CA3 area… More >

WENZHUO YANG^1,#, HAODONG CHEN^2,#, ZHILAN ZHANG³, ZHIYONG XIA³, YUANYUAN JIN^1,*, ZHAOYONG YANG^1,*

Oncology Research, Vol.33, No.6, pp. 1485-1494, 2025, DOI:10.32604/or.2025.059426 - 29 May 2025

Abstract Background: Human natural killer (NK) cells have attracted widespread attention as a potential adoptive cell therapy (ACT). However, the therapeutic effects of NK cell infusion in patients with solid tumors are limited. There is an urgent need to explore a suitable new treatment plan to overcome weaknesses and support the superior therapeutic activity of NK cells. Methods: In this study, the mechanisms underlying the susceptibility of gastric cancer (GC) cell lines AGS, HGC-27, and NCI-N87 to NK cell-mediated cytotoxicity were explored. Results: Lactic dehydrogenase (LDH) release assays showed that all three GC cell lines were susceptible… More >

Mohamed A.G. Hazber^1,*, Ebrahim Mohammed Senan^2,3, Hezam Saud Alrashidi¹

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.3, pp. 3229-3254, 2025, DOI:10.32604/cmes.2025.062302 - 03 March 2025

Abstract Hepatitis is an infection that affects the liver through contaminated foods or blood transfusions, and it has many types, from normal to serious. Hepatitis is diagnosed through many blood tests and factors; Artificial Intelligence (AI) techniques have played an important role in early diagnosis and help physicians make decisions. This study evaluated the performance of Machine Learning (ML) algorithms on the hepatitis data set. The dataset contains missing values that have been processed and outliers removed. The dataset was counterbalanced by the Synthetic Minority Over-sampling Technique (SMOTE). The features of the data set were processed… More >

IOANA MARIA MIHAI¹, GANG WANG^1,2,*

Oncology Research, Vol.33, No.3, pp. 533-547, 2025, DOI:10.32604/or.2024.055155 - 28 February 2025

Abstract The advent of precision medicine has underscored the importance of biomarkers in predicting therapy response for bladder cancer, a malignancy marked by considerable heterogeneity. This review critically examines the current landscape of biomarkers to forecast treatment outcomes in bladder cancer patients. We explore a range of biomarkers, including genetic, epigenetic, proteomic, and transcriptomic indicators, from multiple sample sources, including urine, tumor tissue and blood, assessing their efficacy in predicting responses to chemotherapy, immunotherapy, and targeted therapies. Despite promising developments, the translation of these biomarkers into clinical practice faces significant challenges, such as variability in biomarker More >