Kasidit Kokkhunthod¹, Khomdet Phapatanaburi², Wongsathon Pathonsuwan¹, Talit Jumphoo¹, Patikorn Anchuen³, Porntip Nimkuntod⁴, Monthippa Uthansakul¹, Peerapong Uthansakul^1,*

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 1775-1794, 2024, DOI:10.32604/cmc.2024.049276

Abstract Monitoring blood pressure is a critical aspect of safeguarding an individual’s health, as early detection of abnormal blood pressure levels facilitates timely medical intervention, ultimately leading to a reduction in mortality rates associated with cardiovascular diseases. Consequently, the development of a robust and continuous blood pressure monitoring system holds paramount significance. In the context of this research paper, we introduce an innovative deep learning regression model that harnesses phonocardiogram (PCG) data to achieve precise blood pressure estimation. Our novel approach incorporates a convolutional neural network (CNN)-based regression model, which not only enhances its adaptability to… More >

Syed Ayaz Ali Shah^1,*, Aamir Shahzad^1,*, Musaed Alhussein², Chuan Meng Goh³, Khursheed Aurangzeb², Tong Boon Tang⁴, Muhammad Awais⁵

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2565-2583, 2024, DOI:10.32604/cmc.2024.047597

Abstract Diagnosing various diseases such as glaucoma, age-related macular degeneration, cardiovascular conditions, and diabetic retinopathy involves segmenting retinal blood vessels. The task is particularly challenging when dealing with color fundus images due to issues like non-uniform illumination, low contrast, and variations in vessel appearance, especially in the presence of different pathologies. Furthermore, the speed of the retinal vessel segmentation system is of utmost importance. With the surge of now available big data, the speed of the algorithm becomes increasingly important, carrying almost equivalent weightage to the accuracy of the algorithm. To address these challenges, we present… More > Graphic Abstract

Meiyan Zhang¹, Boqi Zhao¹, Jipu Li², Qisong Wang^1,*, Dan Liu¹, Jinwei Sun¹, Jingxiao Liao^1,*

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1039-1061, 2024, DOI:10.32604/cmc.2024.048643

Abstract Driving fatigue is a physiological phenomenon that often occurs during driving. After the driver enters a fatigued state, the attention is lax, the response is slow, and the ability to deal with emergencies is significantly reduced, which can easily cause traffic accidents. Therefore, studying driver fatigue detection methods is significant in ensuring safe driving. However, the fatigue state of actual drivers is easily interfered with by the external environment (glasses and light), which leads to many problems, such as weak reliability of fatigue driving detection. Moreover, fatigue is a slow process, first manifested in physiological… More >

KARAN WADHWA¹, PAYAL CHAUHAN¹, SHOBHIT KUMAR², RAKESH PAHWA^3,*, RAVINDER VERMA⁴, RAJAT GOYAL⁵, GOVIND SINGH¹, ARCHANA SHARMA⁶, NEHA RAO³, DEEPAK KAUSHIK^1,*

Oncology Research, Vol.32, No.5, pp. 877-897, 2024, DOI:10.32604/or.2024.047278

Abstract Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive More > Graphic Abstract

LEI WANG^1,2, ZHI-HANG WANG¹, NIAN-PING CAO¹, BOBO CHEN¹, CHONG-JUN HUANG¹, LEI YANG¹, YE TIAN^1,*

BIOCELL, Vol.48, No.2, pp. 191-203, 2024, DOI:10.32604/biocell.2023.045349

Abstract Estrogen-related receptor alpha can significantly affect cell metabolism and play key regulatory roles in healthy and diseased organisms. ERRα is also related to the onset and progression of various cancer types. ERRα is primarily expressed in metabolically active tissues and regulates the transcription of metabolic genes in such tissues. It coordinates metabolism and energy demand, affects osteoblasts, osteoclasts, and chondrocytes, promotes muscle regeneration, participates in angiogenesis, and regulates cell aging. In this study, the literature related to the identification of ERRα in skeletal, muscular, and vascular systems was reviewed to further elucidate this receptor. More >

Thean Heng Tan¹, Najihah Mohd Hashim², Wageeh Abdulhadi Yehya Dabdawb¹, Mochamad Zakki Fahmi^3,*, Hwei Voon Lee^1,*

Journal of Renewable Materials, Vol.12, No.1, pp. 29-43, 2024, DOI:10.32604/jrm.2023.043449

Abstract The study focuses on the development of biocompatible and stable FA-functionalized nanocrystalline cellulose (NCC) as a potential drug delivery system for targeting folate receptor-positive cancer cells. The FA-functionalized NCCs were synthesized through a series of chemical reactions, resulting in nanoparticles with favorable properties for biomedical applications. The microstructural analysis revealed that the functionalized NCCs maintained their rod-shaped morphology and displayed hydrodynamic diameters suitable for evading the mononuclear phagocytic system while being large enough to target tumor tissues. Importantly, these nanoparticles possessed a negative surface charge, enhancing their stability and repelling potential aggregation. The binding specificity… More > Graphic Abstract

Siti Nur Ainsyah Ghani¹, Noor Fadiya Mohd Noor^1,2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.1, pp. 1017-1037, 2024, DOI:10.32604/cmes.2023.031372

Abstract Variant graphene, graphene oxides (GO), and graphene nanoplatelets (GNP) dispersed in blood-based copper (Cu) nanoliquids over a leaning permeable cylinder are the focus of this study. These forms of graphene are highly beneficial in the biological and medical fields for cancer therapy, anti-infection measures, and drug delivery. The non-Newtonian Sutterby (blood-based) hybrid nanoliquid flows are generalized within the context of the Tiwari-Das model to simulate the effects of radiation and heating sources. The governing partial differential equations are reformulated into a nonlinear set of ordinary differential equations using similar transformational expressions. These equations are then… More >

Shiyue Zhang¹, Xue Song^1,2, Jingying Wang^1,*, Wen Huang^3,*, Yue Zhou⁴, Mingrui Li¹

Molecular & Cellular Biomechanics, Vol.20, No.2, pp. 81-94, 2023, DOI:10.32604/mcb.2023.044445

Abstract Pulmonary embolism (PE), caused by deep venous thrombosis (DVT), is a disease with high morbidity and mortality. Implantation of inferior vena cava filters is an important method for the clinical prevention of PE. The hemodynamic characteristics of filters implanted in the inferior vena cava (IVC) have a significant impact on their performance. However, IVC diameters vary among patients. This may have a direct impact on the hemodynamic properties of the filter. At present, there is no research on this kind of problem to be investigated. In this paper, the hemodynamic properties of the VenaTech convertible… More > Graphic Abstract

Dongyun Bie^1,#, Hongbai Wang^1,#, Chaobin Zhang², Chunrong Wang³, Yuan Jia¹, Su Yuan¹, Sheng Shi¹, Jiangshan Huang¹, Jianhui Wang^1,*, Fuxia Yan^1,*

Congenital Heart Disease, Vol.18, No.4, pp. 475-488, 2023, DOI:10.32604/chd.2023.028017

Abstract Purpose: This study sought to explore the effect of intraoperative mean blood glucose levels and variability on postoperative acute kidney injury (AKI) in children undergoing congenital cardiac surgery. Methods: We conducted a prospective nested case-control study in children (age < 18 years) undergoing congenital heart surgery with cardiopulmonary bypass (CPB) at the Fuwai Hospital between April 01, 2022 and July 30, 2022. Cases were individuals who developed AKI within the first postoperative 7 days (AKI group) and controls were those without AKI (Non-AKI group) according to KDIGO criteria. AKI and Non-AKI groups unmatched and 1:1 matched by… More > Graphic Abstract

Peishuo Wu¹, Chi Zhu^1,2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.1, pp. 1-2, 2023, DOI:10.32604/icces.2023.09869

Abstract Central blood pressure, i.e., the blood pressure near the heart, is an important physiological indicator of the cardiovascular function of a patient. However, direct measurement of this quantity is rarely carried out due to the invasive nature of the procedure. Instead, blood pressure at the arm (brachial artery) measured through an inflatable cuff is commonly used to represent or estimate the central blood pressure. On the other hand, the aortic pressure propagates downstream in the form of pulse waves, which have to pass through a complex and compliant vascular network to reach the brachial artery.… More >