Yongqiang Li^1,#, Changxin Lai^1,#, Chengchen Zhang², Alexa Singer¹, Suhao Qiu¹, Boming Sun², Michael S. Sacks³, Yuan Feng^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 111-111, 2019, DOI:10.32604/mcb.2019.07098

Abstract Surgeries such as implantation of deep brain stimulation devices require accurate placement of devices within the brain. Because placement affects performance, image guidance and robotic assistance techniques have been widely adopted. These methods require accurate prediction of brain deformation during and following implantation. In this study, a magnetic resonance (MR) image-based finite element (FE) model was proposed by using a coupled Eulerian-Lagrangian method. Anatomical accuracy was achieved by mapping image voxels directly to the volumetric mesh space. The potential utility was demonstrated by evaluating the effect of different surgical approaches on the deformation of the corpus callosum (CC) region. The… More >

Ning Jiang^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 102-102, 2019, DOI:10.32604/mcb.2019.07486

Abstract Force is not only involved in motion, but also involved in molecular interactions that guide cells to execute important physiological functions. Getting to know Dr. Fung at an early age shaped my college major decision, which lead me into the field of biomedical engineering. Applying a force-based measurement tool to study T cell receptor interaction with ligands in graduate school prepared me to use technology development as a foundation to answer important biological and clinical questions.
By combining engineering principle, quantitative modeling, and a deep understanding of biology and medicine, my current research focuses in systems immunology and immune… More >

Taiji Adachi^1,*, Yoshitaka Kameo¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 88-88, 2019, DOI:10.32604/mcb.2019.07417

Abstract Bone adaptation by remodeling is a process to change its outer shape and internal structure to the changing mechanical environment by osteoclastic bone resorption and osteoblastic bone formation. These cellular activities are regulated by mechanosensory network of osteocytes embedded in bone matrix. An imbalance between bone resorption and formation due to low loadings or disuse results in metabolic bone disorders such as osteoporosis. Many studies have identified various signaling pathways that regulate these cellular activities; however, the physiological and pathological conditions of bone as a system remain difficult to understand because of the complexity of the signaling networks including mechano-biochemical… More >

Wei Sun^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 64-64, 2019, DOI:10.32604/mcb.2019.08533

Abstract Fluid–structure interaction (FSI) is a common phenomenon in biological systems. FSI problems of practical interest, such as fish/mammalian swimming, insect/bird flight, and human cardiac blood flow and respiration often involve multiple 3D immersed bodies with complex geometries undergoing very large structural displacements, and inducing very complex flow phenomena. Simulation of heart valve FSI is a technically challenging problem due to the large deformation of the valve leaflets through the cardiac fluid domain in the atrium and ventricular chambers.
Recently, we developed a FSI computational framework [1] for modeling patient-specific left heart (LH) dynamics using smoothed particle hydrodynamics (SPH) for… More >

Yue Mei^1,2,3, Stephane Avril^3,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 44-44, 2019, DOI:10.32604/mcb.2019.07034

Abstract Characterizing regional variations of material properties in soft tissues is essential for biomedical engineering and clinical medicine, including but not limited to cancerous disease detection and patient-specific surgical planning of cardiovascular diseases. Identification of nonhomogeneous material property distribution usually requires solving inverse problems in nonlinear elasticity. Generally, inverse algorithms can be categorized into two groups: iterative inversion and direct inversion. In direct inversion, the material property distribution of soft tissues is estimated directly from the equilibrium equations, while the inverse problem is posed as an optimization problem in iterative inversion. In this presentation, we compare the performance of one direct… More >

Liang Wang¹, Haibo Jia², Luping He², Rui Lv¹, Xiaoya Guo³, Chun Yang^4,5, Don P. Giddens^6,7, Habib Samady⁶, Akiko Maehara⁸, Gary S. Mintz⁸, Dalin Tang^1,*,5

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 23-24, 2019, DOI:10.32604/mcb.2019.07522

Abstract Plaque erosion, one of the primary causes for coronary thrombosis, is responsible for about one third of the patients with acute coronary syndrome (ACS) [1]. Histological studies characterized the eroded plaque as a plaque with following morphological features: 1) plaque intima having direct contact with intraluminal thrombus due to the absence of endothelium or endothelial injury; 2) without rupture in the fibrous cap; 3) abundance of proteoglycans and smooth muscle cells on the luminal surface under the thrombus [2]. These characteristics has been applied in in vivo diagnosis of plaque erosion using optical coherence tomography (OCT) imaging technology and specific… More >

Guixue Wang^1,*, Li Yang¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 10-10, 2019, DOI:10.32604/mcb.2019.08410

Abstract The biomechanics research of Chongqing University (CQU) began in the late 1970s, which has always been guided and helped by Prof. YC Fung. Prof. YP Wu, Prof. GR Wang at CQU were two of the earliest four Chinese scholars to visit and study in Fung's laboratory in the United States. In the autumn of 1979, Fung held a biomechanical workshop in CQU and the former Huazhong Institute of Technology. With the help of him, Prof. YP Wu founded the first Biomechanics Research Lab in China in the late 1970s. The first program for master’s degree on biomechanics was approved to… More >

J.D. Humphrey^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 3-4, 2019, DOI:10.32604/mcb.2019.07639

Abstract This article has no abstract. More >

Savio L-Y. Woo^1,*, Peter C-Y Chen²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 1-2, 2019, DOI:10.32604/mcb.2019.07631

Abstract This article has no abstract. More >

Shu Chien

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 1-2, 2019, DOI:10.32604/mcb.2019.07695

Abstract Professor Y.C. Fung has made tremendous impacts on science, engineering and humanity through his research and its applications, educating many students and their students, and providing his exemplary leadership [1-3]. He has applied his profound knowledge and elegant analytical methods to the study of biomedical problems with rigor and excellence. He established the basic principles of biomechanics in living tissues and organs. He opened up new vista for bioengineering, from organs-systems to molecules-genes, and he has provided the foundation of research activities in many institutions in the United States and the world. He has made outstanding contributions to education in… More >