Yuhang Li^1,*, Jin Nan¹, Yang Wang¹, Yafei Yin¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.013412

Abstract As a new type of electronic device, stretchable bio-integrated devices are generally composed of inorganic functional components, stretchable interconnected structures, soft biocompatible substrates and encapsulations, and have wide adaptability to a variety of complex surfaces of soft biological tissues. The small size of functional components, the thin substrate thickness, and poor thermal conductivity can easily lead to thermal burns caused by local temperature concentration in biological tissues. The unique microstructure characteristics and biological thermal characteristics of biological tissues make the heat transfer behavior of integrated devices in biological tissues significantly different from the traditional Fourier… More >

Nazia Afrin^a,*, Jonathan Lopez, Juan Ocampo

Frontiers in Heat and Mass Transfer, Vol.18, pp. 1-7, 2022, DOI:10.5098/hmt.18.46

Abstract Large number of numerical computer simulations in engineering places is a serious burden on associated optimization problems nowadays. Kriging Surrogate based optimization (KSBO) becomes standard practice in analyzing expensive and time-consuming simulation. This paper aims to investigate the surrogate based analyze and optimization of thermal damage in living biological tissue by laser irradiation using a generalized duel phase model. The relationships of maximum temperature and thermal damage in living biological tissues of the response with two variables at a time are studied. The result shows that the surrogate model predicted response variables i.e, temperature and More >

Bei Liu¹, Xian Zhang^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.130, No.3, pp. 1547-1563, 2022, DOI:10.32604/cmes.2022.018130 - 30 December 2021

Abstract During high-intensity focused ultrasound (HIFU) treatment, the accurate identification of denatured biological tissue is an important practical problem. In this paper, a novel method based on the improved variational mode decomposition (IVMD) and autoregressive (AR) model was proposed, which identified denatured biological tissue according to the characteristics of ultrasonic scattered echo signals during HIFU treatment. Firstly, the IVMD method was proposed to solve the problem that the VMD reconstruction signal still has noise due to the limited number of intrinsic mode functions (IMF). The ultrasonic scattered echo signals were reconstructed by the IVMD to achieve… More >

Nazia Afrin^a , Yuwen Zhang^b,*

Frontiers in Heat and Mass Transfer, Vol.12, pp. 1-6, 2019, DOI:10.5098/hmt.12.27

Abstract The surrogate-based analysis and optimization of thermal damage in living biological tissue by laser irradiation are discussed in this paper. Latin Hypercube Sampling (LHS) and Response Surface Model (RSM) are applied to study the surrogate-based optimization of thermal damage in tissue using a generalized dual-phase lag model. Response value of high temperature as a function of input variables and the relationship of maximum temperature and thermal damage as a function of input variables are investigated. Comparisons of SBO model and simulation results for different sample sizes are examined. The results show that every input variable More >

R.A. Regueiro^1,2, B. Zhang², S.L. Wozniak³

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.1, pp. 1-39, 2014, DOI:10.3970/cmes.2014.098.001 - 16 August 2021

Abstract The paper presents three-dimensional, large deformation, coupled finite element analysis (FEA) of dynamic loading on soft biological tissues treated as biphasic (solid-fluid) porous media. An overview is presented of the biphasic solidfluid mixture theory at finite strain, including inertia terms. The solid skeleton is modeled as an isotropic, compressible, hyperelastic material. FEA simulations include: (1) compressive uniaxial strain loading on a column of lung parenchyma with either pore air or water fluid, (2) out-of-plane pressure loading on a thin slab of lung parenchyma with either pore air or water fluid, and (3) pressure loading on More >

G.V. Norton^*, J.C. Novarini^†

Molecular & Cellular Biomechanics, Vol.4, No.2, pp. 75-86, 2007, DOI:10.3970/mcb.2007.004.075

Abstract Ultrasonic imaging in medical applications involves propagation and scattering of acoustic waves within and by biological tissues that are intrinsically dispersive. Analytical approaches for modeling propagation and scattering in inhomogeneous media are difficult and often require extremely simplifying approximations in order to achieve a solution. To avoid such approximations, the direct numerical solution of the wave equation via the method of finite differences offers the most direct tool, which takes into account diffraction and refraction. It also allows for detailed modeling of the real anatomic structure and combination/layering of tissues. In all cases the correct… More >

Jianhua Zhou^∗, J. K. Chen^†, Yuwen Zhang^‡

Molecular & Cellular Biomechanics, Vol.4, No.1, pp. 27-40, 2007, DOI:10.3970/mcb.2007.004.027

Abstract A bioheat transfer approach is proposed to study thermal damage in biological tissues caused by laser radiation. The laser light propagation in the tissue is first solved by using a robust seven-flux model in cylindrical coordinate system. The resulting spatial distribution of the absorbed laser energy is incorporated into the bioheat transfer equation for solving temperature response. Thermal damage to the tissue is assessed by the extent of denatured protein using a rate process equation. It is found that for the tissue studied, a significant protein denaturation process would take place when temperature exceeds about More >

Leo Q. Wan^1,1, Chester Miller^1,1, X. Edward Guo^2,2, Van C. Mow^1,1,3,3

Molecular & Cellular Biomechanics, Vol.1, No.1, pp. 81-100, 2004, DOI:10.3970/mcb.2004.001.081

Abstract The triphasic constitutive law [Lai, Hou and Mow (1991)] has been shown in some special 1D cases to successfully model the deformational and transport behaviors of charged-hydrated, porous-permeable, soft biological tissues, as typified by articular cartilage. Due to nonlinearities and other mathematical complexities of these equations, few problems for the deformation of such materials have ever been solved analytically. Using a perturbation procedure, we have linearized the triphasic equations with respect to a small imposed axial compressive strain, and obtained an equilibrium solution, as well as a short-time boundary layer solution for the mechano- electrochemical… More >