Tamara ZAOBORNYJ, Darío E. IGLESIAS, Silvina S. BOMBICINO, Alberto BOVERIS, Laura B. VALDEZ*
BIOCELL, Vol.40, No.1, pp. 55-58, 2016, DOI:10.32604/biocell.2016.40.055
Abstract Normal cardiac function is accomplished through a continuous energy supply provided by
mitochondria. Heart mitochondria are the major source of reactive oxygen and nitrogen species: superoxide
anion (O2-) and nitric oxide (NO). NO production by mitochondrial NOS (mtNOS) is modified by metabolic
state and shows an exponential dependence on Δψ. The interaction between mtNOS and complexes I and IV
might be a mechanism involved in the regulation of mitochondrial NO production. NO exerts a high affinity,
reversible and physiological inhibition of cytochrome c oxidase activity. A second effect of NO on the respiratory
chain is accomplished More >
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