Paolo D’Ambrosio1,2, Derek Tran1,2, Charlotte E. Verrall3,4, Chantal Attard5, Maria Fiatarone Singh6,7, Julian Ayer3,4,8, Yves d’Udekem5,9,10, Stephen Twigg2,11, David S. Celermajer1,2,12, Rachael Cordina1,2,5
Congenital Heart Disease, Vol.14, No.6, pp. 987-995, 2019, DOI:10.1111/chd.12836
Abstract Objective and Patients: This study aimed to characterize bone mineral density abnormalities and pathophysiological associations in young adults living with a Fontan
circulation.
Design: Participants underwent bone mineral density measurement using dual‐energy X‐ray absorptiometry and serum biochemical analysis, cardiopulmonary exercise and strength testing and transthoracic echocardiography.
Results: In our cohort (n = 28), 29% had osteopenic‐range bone mineral density and
one patient was osteoporotic (average hip t score: −0.6 ± 1.1; spine t score: −0.6 ± 0.9).
Four patients (14%) had z scores < −2.0. Parathyroid hormone levels were increased
compared with laboratory median (6.1 ± 3.5 vs… More >
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