Jun Oyamada1, Chisato Shimizu1, Jihoon Kim2, Matthew R. Williams1,3, Eileen Png4, Martin L. Hibberd4, Adriana H. Tremoulet1,3, James C. Perry1,3, Jane C. Burns1,3
Congenital Heart Disease, Vol.14, No.2, pp. 213-220, 2019, DOI:10.1111/chd.12696
Abstract Background: We previously described the association of genetic variants in calcium
channel genes and susceptibility to Kawasaki disease (KD), an acute, self‐limited vas‐
culitis, and the most common cause of acquired cardiac disease in children. Abnormal
repolarization of cardiomyocytes and changes in T wave morphology have been re‐
ported in KD but have not been studied systematically.
Methods: We analyzed acute and convalescent ECG T wave morphology in two inde‐
pendent cohorts of KD subjects and studied the association between bifid T waves
and genetic variants in previously reported genes with SNVs associated with cardiac
repolarization.
Results: Bifid… More >
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