TATIANA KURILO^*, REBECCA D. PENTZ

Oncology Research, Vol.32, No.9, pp. 1401-1406, 2024, DOI:10.32604/or.2024.050266 - 23 August 2024

Abstract Objectives: Rural patients have poor cancer outcomes and clinical trial (CT) enrollment compared to urban patients due to attitudinal, awareness, and healthcare access differential. Knowledge of cancer survival disparities and CT enrollment is important for designing interventions and innovative approaches to address the stated barriers. The study explores the potential disparities in cancer survival rates and clinical trial enrollments in rural and urban breast and lung cancer patients. Our hypotheses are that for both cancer types, urban cancer patients will have longer 5-year survival rates and higher enrollment rates in clinical trials than those in… More >

Ponusa Songtipya^1,2,*, Thummanoon Prodpran^1,2, Ladawan Songtipya^1,2, Theerarat Sengsuk¹

Journal of Renewable Materials, Vol.12, No.5, pp. 951-967, 2024, DOI:10.32604/jrm.2024.049068 - 17 July 2024

Abstract The synergistic effect of organoclay (OC) and zinc oxide (ZnO) nanoparticles on the crucial properties of poly(lactic acid) (PLA) nanocomposite films was systematically investigated herein. After their incorporation into PLA via the solvent casting technique, the water vapor barrier property of the PLA/OC/ZnO film improved by a maximum of 86% compared to the neat PLA film without the deterioration of Young’s modulus or the tensile strength. Moreover, the film’s self-antibacterial activity against foodborne pathogens, including gram-negative (Escherichia coli, E. coli) and gram-positive (Staphylococcus aureus, S. aureus) bacteria, was enhanced by a maximum of approximately 98–99% compared to the neat… More > Graphic Abstract

KARAN WADHWA¹, PAYAL CHAUHAN¹, SHOBHIT KUMAR², RAKESH PAHWA^3,*, RAVINDER VERMA⁴, RAJAT GOYAL⁵, GOVIND SINGH¹, ARCHANA SHARMA⁶, NEHA RAO³, DEEPAK KAUSHIK^1,*

Oncology Research, Vol.32, No.5, pp. 877-897, 2024, DOI:10.32604/or.2024.047278 - 23 April 2024

Abstract Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive More > Graphic Abstract

HUAN HU^1,2,*, YUE HUANG¹, FANGZHOU LIU¹, QIAN WANG^1,2, YANZI YAO^3,*

BIOCELL, Vol.48, No.3, pp. 353-362, 2024, DOI:10.32604/biocell.2024.048311 - 15 March 2024

Abstract Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more prevalent. These conditions represent a common, costly and chronic burden, not only for elderly but also to society at large. Consequently, elucidating the pathophysiology and developing effective therapies for these diseases is of paramount importance. Recent advances in research have identified the gut as a novel and promising target for addressing bone disorders, giving rise to the concept of the “gut-bone axis”. An in-depth review of the latest insights into the effects of age-related physiological changes More >

Yu Huang¹, Beilei Liu¹, Dianlei Feng^2,*, Hao Shi¹

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1679-1699, 2024, DOI:10.32604/cmes.2023.044094 - 29 January 2024

Abstract Rigid barrier deflectors can effectively prevent overspilling landslides, and can satisfy disaster prevention requirements. However, the mechanisms of interaction between natural granular flow and rigid barrier deflectors require further investigation. To date, few studies have investigated the impact of deflectors on controlling viscous debris flows for geological disaster prevention. To investigate the effect of rigid barrier deflectors on impact mechanisms, a numerical model using the smoothed particle hydrodynamics (SPH) method with the Herschel–Bulkley model is proposed to simulate the interaction between natural viscous flow and single/dual barriers with and without deflectors. This model was validated… More > Graphic Abstract

Xuhang Lin¹, Haibo Chen^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.09388

Abstract As an important and useful tool for reducing noise, the sound barrier is of practical significance. The sound barrier has different noise reduction effects for different sizes, shapes and properties of the sound absorbing material. Liu et al. [1] have performed shape optimization of sound barriers by using isogeometric boundary element method and method of moving asymptotes (MMA). However, in engineering practice, it is difficult to determine some parameters accurately such as material properties, geometries, external loads. Therefore, it is necessary to consider these uncertainty conditions in order to ensure the rationality of the numerical… More >

Pan Li¹, Xiaochao Jin¹, Pin Lv¹, Xueling Fan^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.010540

Abstract Refurbishment of thermal barrier coating (TBC) has become a valuable technique to prolong the service life of high-temperature components. In this work, the effect of refurbishment process on the oxidation behaviors of TBC was investigated. Before recoating, the soft chemical stripping method was used to remove TBC from DD6 single-crystal superalloy. The results showed that a certain amount of IDZ layer with Cr-rich would be retained in the DD6 superalloy substrate after coating removal. The characteristics of the β phases change from the elongated grain shapes and a high aspect ratio in the ordinary specimens… More >

LONGSHENG FU¹, JINFANG HU¹, FENG SHAO², YAOQI WU¹, WEI BAI³, MINGJIN JIANG³, HAO CHEN⁴, LIHUA CHEN², YANNI LV^1,*

BIOCELL, Vol.47, No.8, pp. 1869-1883, 2023, DOI:10.32604/biocell.2023.028602 - 28 August 2023

Abstract Background: Biochanin A is an excellent dietary isoflavone that has the concomitant function of both medicine and foodstuff. The attenuation function of biochanin A on blood-brain barrier (BBB) damage induced by cerebral ischemia-reperfusion remains unclear. Methods: C57BL/6 mice were subjected to 1 h middle cerebral artery occlusion (MCAO) followed by 24 h reperfusion. The infarct volume of the brain was stained by TTC, while leakage of the brain was quantitatively stained by Evans blue, and the neurologic deficit score was measured. Microglial-induced morphologic changes were observed via immunofluorescence staining, and rolling and adhering leukocytes in… More >

Junling Qiu^*, Huihui Sun, Shuya Wang

CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.3, pp. 2077-2109, 2023, DOI:10.32604/cmes.2023.027353 - 03 August 2023

Abstract As indispensable components of superconducting circuit-based quantum computers, Josephson junctions determine how well superconducting qubits perform. Reverse Monte Carlo (RMC) can be used to recreate Josephson junction’s atomic structure based on experimental data, and the impact of the structure on junctions’ properties can be investigated by combining different analysis techniques. In order to build a physical model of the atomic structure and then analyze the factors that affect its performance, this paper briefly reviews the development and evolution of the RMC algorithm. It also summarizes the modeling process and structural feature analysis of the Josephson More >

Muzi Li^*

CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.3, pp. 2465-2493, 2023, DOI:10.32604/cmes.2023.026827 - 03 August 2023

Abstract Modular construction as an innovative method aids the construction industry in transforming to off-site construction production with high efficiency and environmental friendliness. Despite the obvious advantages, the uptake of modular construction is not booming as expected. However, previous studies have investigated and summarized the barriers to the adoption of modular construction. In this research, a Large-Scale Group Decision Making (LSGDM)- based analysis is first made of the severity of barriers to modular construction adoption from the perspective of construction stakeholders. In addition, the Technology-Organization-Environment (TOE) framework is utilized to identify the barriers based on three More >