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  • Open Access

    ARTICLE

    Optimizing Hybrid Fibre-Reinforced Polymer Bars Design: A Machine Learning Approach

    Aneel Manan1, Pu Zhang1,*, Shoaib Ahmad2, Jawad Ahmad2

    Journal of Polymer Materials, Vol.41, No.1, pp. 15-44, 2024, DOI:10.32604/jpm.2024.053859

    Abstract Fiber-reinforced polymer (FRP) bars are gaining popularity as an alternative to steel reinforcement due to their advantages such as corrosion resistance and high strength-to-weight ratio. However, FRP has a lower modulus of elasticity compared to steel. Therefore, special attention is required in structural design to address deflection related issues and ensure ductile failure. This research explores the use of machine learning algorithms such as gene expression programming (GEP) to develop a simple and effective equation for predicting the elastic modulus of hybrid fiber-reinforced polymer (HFPR) bars. A comprehensive database of 125 experimental results of HFPR… More >

  • Open Access

    ARTICLE

    Properties of Bark Particleboard Bonded with Demethylated Lignin Adhesives Derived from Leucaena leucocephala Bark

    Rafidah Md Salim1,2,*, Jahimin Asik2, Mohd Sani Sarjadi2

    Journal of Renewable Materials, Vol.12, No.4, pp. 737-769, 2024, DOI:10.32604/jrm.2024.045695

    Abstract Lignin extraction from bark can maximize the utilization of biomass waste, offer cost-effectiveness, and promote environmental friendliness when employed as an adhesive material in bark particleboard production. Particles of fine (0.2 to 1.0 mm), medium (1.0 to 2.5 mm), and coarse (2.5 to 12.0 mm) sizes, derived from the bark of Leucaena leucocephala, were hot-pressed using a heating plate at 175°C for 7 min to create single-layer particleboards measuring 320 mm × 320 mm × 10 mm, targeting a density of 700 kg/m. Subsequently, the samples were trimmed and conditioned at 20°C and 65% relative humidity.… More > Graphic Abstract

    Properties of Bark Particleboard Bonded with Demethylated Lignin Adhesives Derived from <i>Leucaena leucocephala</i> Bark

  • Open Access

    ARTICLE

    Crude Flavonoid Extract of Medicinal Herb Zingibar officinale Inhibits Proliferation and Induces Apoptosis in Hepatocellular Carcinoma Cells

    Ayman I. Elkady*†, Osama A. Abu-Zinadah*, Rania Abd El Hamid Hussein‡§

    Oncology Research, Vol.25, No.6, pp. 897-912, 2017, DOI:10.3727/096504016X14816352324532

    Abstract There is an urgent need to improve the clinical management of hepatocellular carcinoma (HCC), one of the most common causes of global cancer-related deaths. Zingibar officinale is a medicinal herb used throughout history for both culinary and medicinal purposes. It has antioxidant, anticarcinogenic, and free radical scavenging properties. Previously, we proved that the crude flavonoid extract of Z. officinale (CFEZO) inhibited growth and induced apoptosis in several cancer cell lines. However, the effect of the CFEZO on an HCC cell line has not yet been evaluated. In this study, we explored the anticancer activity of CFEZO against… More >

  • Open Access

    ARTICLE

    Enhancing Renewable Energy Integration: A Gaussian-Bare-Bones Levy Cheetah Optimization Approach to Optimal Power Flow in Electrical Networks

    Ali S. Alghamdi1,*, Mohamed A. Zohdy2, Saad Aldoihi3,4

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 1339-1370, 2024, DOI:10.32604/cmes.2024.048839

    Abstract In the contemporary era, the global expansion of electrical grids is propelled by various renewable energy sources (RESs). Efficient integration of stochastic RESs and optimal power flow (OPF) management are critical for network optimization. This study introduces an innovative solution, the Gaussian Bare-Bones Levy Cheetah Optimizer (GBBLCO), addressing OPF challenges in power generation systems with stochastic RESs. The primary objective is to minimize the total operating costs of RESs, considering four functions: overall operating costs, voltage deviation management, emissions reduction, voltage stability index (VSI) and power loss mitigation. Additionally, a carbon tax is included in… More >

  • Open Access

    ARTICLE

    A Comprehensive Investigation on Shear Performance of Improved Perfobond Connector

    Caiping Huang*, Zihan Huang, Wenfeng You

    Structural Durability & Health Monitoring, Vol.18, No.3, pp. 299-320, 2024, DOI:10.32604/sdhm.2024.047850

    Abstract This paper presents an easily installed improved perfobond connector (PBL) designed to reduce the shear concentration of PBL. The improvement of PBL lies in changing the straight penetrating rebar to the Z-type penetrating rebar. To study the shear performance of improved PBL, two PBL test specimens which contain straight penetrating rebar and six improved PBL test specimens which contain Z-type penetrating rebars were designed and fabricated, and push-out tests of these eight test specimens were carried out to investigate and compare the shear behavior of PBL. Additionally, Finite Element Analysis (FEA) models of the PBL… More >

  • Open Access

    REVIEW

    Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

    KARAN WADHWA1, PAYAL CHAUHAN1, SHOBHIT KUMAR2, RAKESH PAHWA3,*, RAVINDER VERMA4, RAJAT GOYAL5, GOVIND SINGH1, ARCHANA SHARMA6, NEHA RAO3, DEEPAK KAUSHIK1,*

    Oncology Research, Vol.32, No.5, pp. 877-897, 2024, DOI:10.32604/or.2024.047278

    Abstract Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive More > Graphic Abstract

    Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

  • Open Access

    ARTICLE

    The Epstein-Barr virus-miRNA-BART6-5p regulates TGF-β/SMAD4 pathway to induce glycolysis and enhance proliferation and metastasis of gastric cancer cells

    XUHUI ZHAO1,2, XIAOMIN HUANG1, CHUNYAN DANG2, XIA WANG1, YUJIAO QI3, HONGLING LI2,*

    Oncology Research, Vol.32, No.5, pp. 999-1009, 2024, DOI:10.32604/or.2024.046679

    Abstract Background: EBV-miR-BARTs exhibit significant relevance in epithelial tumors, particularly in EBV-associated gastric and nasopharyngeal cancers. However, their specific mechanisms in the initiation and progression of gastric cancer remain insufficiently explored. Material and Methods: Initially, EBV-miRNA-BART6-5p and its target gene SMAD4 expression were assessed in EBV-associated gastric cancer tissues and cell lines. Subsequent transfection induced overexpression of EBV-miRNA-BART6-5p in AGS and MKN-45, and downregulation in EBV-positive cells (SUN-719). The subsequent evaluation aimed to observe their impact on gastric cancer cell proliferation, migration, and glycolytic processes, with the TGF-β/SMAD4 signaling pathway value clarified using a TGF-β inhibitor. Results:More >

  • Open Access

    ARTICLE

    Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF)-Mass Spectrometry and 13C-NMR-Identified New Compounds in Paraberlinia bifoliolata (Ekop-Beli) Bark Tannins

    Liliane Nga1, Benoit Ndiwe1,2, Achille Bernard Biwolé1, Antonio Pizzi3,*, Jean Jalin Eyinga Biwole1, Joseph Zobo Mfomo1

    Journal of Renewable Materials, Vol.12, No.3, pp. 553-568, 2024, DOI:10.32604/jrm.2023.046568

    Abstract Extracts of plant origin, particularly tannins, are attracting growing interest for the sustainable development of materials in the industrial sector. The discovery of new tannins is therefore necessary. The aim of this work was to contribute to the understanding of the properties of Paraberlinia bifoliolata tannin by Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectroscopy MALDI-TOF/MS and Carbon 13 Nuclear Magnetic Resonance (13C NMR). The chemical composition of tannin extracted from Paraberlinia bifoliolata bark was determined, as was the mechanical strength of the resin hardened with Acacia nilotica extracts. Yield by successive water extraction was 35%. MALDI-TOF/MS… More >

  • Open Access

    ARTICLE

    Growth of Non-enzymatic Cholesterol Biosensor using TiO2 Decorated Graphene Oxide with Bare GCE and PPy-GCE

    S. DEIVANAYAKI1,*, P. JAYAMURUGAN2, S. ASHOKAN3, V. GOPALA KRISHNAN4, B. YOGESWARI5

    Journal of Polymer Materials, Vol.38, No.3-4, pp. 295-307, 2021, DOI:10.32381/JPM.2021.38.3-4.10

    Abstract The cholesterol level determination is a significant clinical diagnostic solution for heart and, thrombosis problems. In this work, we examined a novel non-enzymatic cholesterol biosensor using cholesterol oxidase (ChOx) enzyme immobilized on TiO2 nanoparticles influenced by reduced graphene oxide (rGO) - polypyrrole (PPy) (rGO-TiO2 /PPy-GCE) nanocomposite was developed on a glassy carbon electrode (GCE) and the higher sensing response with lower detection limits were observed. The electrochemical properties of GCE modified PPy (PPy-GCE) were studied using CV (Cyclic Voltammetry) and DPV (Differential Pulse Voltammetry). The reported sensor exhibited piecewise linearity in the range of 0.1 µM More >

  • Open Access

    ARTICLE

    Influence of Bottom Inclination on the Flow Structure in a Rotating Convective Layer

    Andrei Vasiliev, Andrei Sukhanovskii*, Elena Popova

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.4, pp. 739-748, 2024, DOI:10.32604/fdmp.2024.048092

    Abstract The formation of convective flows in a rotating cylindrical layer with an inclined bottom and free surface is studied. Convection is driven by localized cooling at the center of the upper free surface and by rim heating at the bottom near the sidewall. The horizontal temperature difference in a rotating layer leads to the formation of a convective flow with a complex structure. The mean meridional circulation, consisting of three cells, provides a strongly non-uniform differential rotation. As a result of the instability of the main cyclonic zonal flow, the train of baroclinic waves appears… More >

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