KARAN WADHWA¹, PAYAL CHAUHAN¹, SHOBHIT KUMAR², RAKESH PAHWA^3,*, RAVINDER VERMA⁴, RAJAT GOYAL⁵, GOVIND SINGH¹, ARCHANA SHARMA⁶, NEHA RAO³, DEEPAK KAUSHIK^1,*

Oncology Research, Vol.32, No.5, pp. 877-897, 2024, DOI:10.32604/or.2024.047278

Abstract Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive and systematic search of… More > Graphic Abstract

XUHUI ZHAO^1,2, XIAOMIN HUANG¹, CHUNYAN DANG², XIA WANG¹, YUJIAO QI³, HONGLING LI^2,*

Oncology Research, Vol.32, No.5, pp. 999-1009, 2024, DOI:10.32604/or.2024.046679

Abstract Background: EBV-miR-BARTs exhibit significant relevance in epithelial tumors, particularly in EBV-associated gastric and nasopharyngeal cancers. However, their specific mechanisms in the initiation and progression of gastric cancer remain insufficiently explored. Material and Methods: Initially, EBV-miRNA-BART6-5p and its target gene SMAD4 expression were assessed in EBV-associated gastric cancer tissues and cell lines. Subsequent transfection induced overexpression of EBV-miRNA-BART6-5p in AGS and MKN-45, and downregulation in EBV-positive cells (SUN-719). The subsequent evaluation aimed to observe their impact on gastric cancer cell proliferation, migration, and glycolytic processes, with the TGF-β/SMAD4 signaling pathway value clarified using a TGF-β inhibitor. Results: EBV-miRNA-BART6-5p exhibits pronounced upregulation… More >

Liliane Nga¹, Benoit Ndiwe^1,2, Achille Bernard Biwolé¹, Antonio Pizzi^3,*, Jean Jalin Eyinga Biwole¹, Joseph Zobo Mfomo¹

Journal of Renewable Materials, Vol.12, No.3, pp. 553-568, 2024, DOI:10.32604/jrm.2023.046568

Abstract Extracts of plant origin, particularly tannins, are attracting growing interest for the sustainable development of materials in the industrial sector. The discovery of new tannins is therefore necessary. The aim of this work was to contribute to the understanding of the properties of Paraberlinia bifoliolata tannin by Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectroscopy MALDI-TOF/MS and Carbon 13 Nuclear Magnetic Resonance (¹³C NMR). The chemical composition of tannin extracted from Paraberlinia bifoliolata bark was determined, as was the mechanical strength of the resin hardened with Acacia nilotica extracts. Yield by successive water extraction was 35%. MALDI-TOF/MS analysis… More >

S. DEIVANAYAKI^1,*, P. JAYAMURUGAN², S. ASHOKAN³, V. GOPALA KRISHNAN⁴, B. YOGESWARI⁵

Journal of Polymer Materials, Vol.38, No.3-4, pp. 295-307, 2021, DOI:10.32381/JPM.2021.38.3-4.10

Abstract The cholesterol level determination is a significant clinical diagnostic solution for heart and, thrombosis problems. In this work, we examined a novel non-enzymatic cholesterol biosensor using cholesterol oxidase (ChOx) enzyme immobilized on TiO₂ nanoparticles influenced by reduced graphene oxide (rGO) - polypyrrole (PPy) (rGO-TiO₂ /PPy-GCE) nanocomposite was developed on a glassy carbon electrode (GCE) and the higher sensing response with lower detection limits were observed. The electrochemical properties of GCE modified PPy (PPy-GCE) were studied using CV (Cyclic Voltammetry) and DPV (Differential Pulse Voltammetry). The reported sensor exhibited piecewise linearity in the range of 0.1 µM to 1 µM and… More >

Andrei Vasiliev, Andrei Sukhanovskii^*, Elena Popova

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.4, pp. 739-748, 2024, DOI:10.32604/fdmp.2024.048092

Abstract The formation of convective flows in a rotating cylindrical layer with an inclined bottom and free surface is studied. Convection is driven by localized cooling at the center of the upper free surface and by rim heating at the bottom near the sidewall. The horizontal temperature difference in a rotating layer leads to the formation of a convective flow with a complex structure. The mean meridional circulation, consisting of three cells, provides a strongly non-uniform differential rotation. As a result of the instability of the main cyclonic zonal flow, the train of baroclinic waves appears in the upper layer. The… More >

HUAN HU^1,2,*, YUE HUANG¹, FANGZHOU LIU¹, QIAN WANG^1,2, YANZI YAO^3,*

BIOCELL, Vol.48, No.3, pp. 353-362, 2024, DOI:10.32604/biocell.2024.048311

Abstract Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more prevalent. These conditions represent a common, costly and chronic burden, not only for elderly but also to society at large. Consequently, elucidating the pathophysiology and developing effective therapies for these diseases is of paramount importance. Recent advances in research have identified the gut as a novel and promising target for addressing bone disorders, giving rise to the concept of the “gut-bone axis”. An in-depth review of the latest insights into the effects of age-related physiological changes in the gastrointestinal tract on… More >

Yu Huang¹, Beilei Liu¹, Dianlei Feng^2,*, Hao Shi¹

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1679-1699, 2024, DOI:10.32604/cmes.2023.044094

Abstract Rigid barrier deflectors can effectively prevent overspilling landslides, and can satisfy disaster prevention requirements. However, the mechanisms of interaction between natural granular flow and rigid barrier deflectors require further investigation. To date, few studies have investigated the impact of deflectors on controlling viscous debris flows for geological disaster prevention. To investigate the effect of rigid barrier deflectors on impact mechanisms, a numerical model using the smoothed particle hydrodynamics (SPH) method with the Herschel–Bulkley model is proposed to simulate the interaction between natural viscous flow and single/dual barriers with and without deflectors. This model was validated using laboratory flume test data… More > Graphic Abstract

Ismail Shah^1,2, Jing Li^1,3,4,*, Nauman Khan⁵, Hamad R. Almujibah⁶, Muhammad Mudassar Rehman², Ali Raza⁷, Yun Peng^3,4

Journal of Renewable Materials, Vol.12, No.1, pp. 167-186, 2024, DOI:10.32604/jrm.2023.031503

Abstract Recycled steel fiber reinforced concrete is an innovative construction material that offers exceptional mechanical properties and durability. It is considered a sustainable material due to its low carbon footprint and environmental friendly characteristics. This study examines the key influencing factors that affect the behavior of this material, such as the steel fiber volume ratio, recycled aggregate replacement rate, concrete strength grade, anchorage length, and stirrup constraint. The study investigates the bond failure morphology, bond-slip, and bond strength constitutive relationship of steel fiber recycled concrete. The results show that the addition of steel fibers at 0.5%, 1.0%, and 1.5% volume ratios… More >

Yangao Hu^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.09773

Abstract This paper investigates the effects of graphene oxide (GO), notch depth, rebar, and load on the resistivity of cement paste and mortar. The electrical conductivity of GO/cement composite reaches its maximum value when the GO content is 0.03%, which is approximately 50% higher compared to the composite without GO. The resistivity of GO/cement composite shows significant changes with increasing load from 0 to 40 kN. The gauge factor for compressive loading varies from about 26 to 73 for different GO contents. Moreover, the resistivity variation with the notch depth in GO/cement is found to be much greater than that in… More >

Ain Raal^1,*, Linda Rusalepp², Tatiana Chiru³, Nicolae Ciobanu³, Kelly Talvistu¹, Michelle Shusta¹, Oleh Koshovyi^1,4, Tõnu Püssa²

Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 2965-2979, 2023, DOI:10.32604/phyton.2023.042723

Abstract The fruits of the Sea buckthorn (Hippophae rhamnoides L.) are a popular plant food and a valuable health product. Cultivating plants produces a lot of leaves with fine branches as an unnecessary residue, which needs valorization. The aim of the study was to estimate (by HPLC-MS/MS) the qualitative and quantitative content of polyphenolic compounds in different parts of H. rhamnoides (HR), and to determine the level of antioxidant activity of leaves and fruits (by DPPH, ABTS methods and ferrozine test). Up to 19 compounds were identified in different parts of HR. The fruits are rich in flavonoids, including various glycosides… More >