SAM SON¹, AKSHAAR BRAHMBHATT¹, KEN ZHAO¹, BRETT MARINELLI¹, JAMES HARDING², WILLIAM JARNAGIN³, GHASSAN K. ABOU-ALFA², HOOMAN YARMOHAMMADI^1,*

Oncology Research, Vol.32, No.12, pp. 1831-1836, 2024, DOI:10.32604/or.2024.052985 - 13 November 2024

Abstract Background: This article aims to present the single-institution outcomes of patients with Fibrolamellar Carcinoma (FLC) treated with liver-directed therapies (LDT). Methods: In this single-center retrospective study, all patients diagnosed with FLC who underwent LDT were identified. Between July 2012 and July 2023, six patients were identified. One patient was excluded due to bleeding. Demographic and clinical parameters were recorded. Complications within 30 days of the LDT were evaluated. Radiological treatment responses at 1, 6, and 12 months were assessed per mRECIST. Results: A total of five patients, which included three females and two males, were reviewed.… More >

Lei Wang^1,*, Blanca Rodriguez², Xiaoyu Luo³, Charles Augarde⁴

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-2, 2024, DOI:10.32604/icces.2024.013350

Abstract Cardiovascular disease is the leading cause of death worldwide. Disease-specific software, like FFRct from HeartFlow, and high-fidelity computational models within a general-purpose software, like Living Heart Project within Abaqus, are essential to revolutionise diagnosis and treatment of cardiovascular disease for clinicians and design of medical devices for industries. This talk presents our past researches on computational modelling of tear propagation in the aortic dissection [1-2] and of electromechanical coupling in the human heart with the finite element method [3], and our current exploration on high-fidelity and efficient computation and software development for diagnosis and treatment More >

Wen Zhang^1,2, Ting Wu^1,2, Xijian Chen^1,3, Hong Luo^1,2,*, Yifei Li^1,4,*

Congenital Heart Disease, Vol.19, No.4, pp. 399-406, 2024, DOI:10.32604/chd.2024.055178 - 31 October 2024

Abstract This article has no abstract. More >

Sherif Negm^1,2, Loic Mace¹, Fedoua El Louali³, Beatrice Desnous⁴, Philipe Aldebert³, Virginie Fouilloux¹, Marien Lenoir^1,*

Congenital Heart Disease, Vol.19, No.3, pp. 267-273, 2024, DOI:10.32604/chd.2024.051642 - 26 July 2024

Abstract The aorto-ventricular tunnel is a rare congenital cardiac anomaly. We present a case of aorto-ventricular tunnel diagnosed via fetal echocardiography. Emergency surgery was performed on the 2nd day of life to close the tunnel, located just in front of the right coronary ostium, due to the patient’s unstable health condition. The postoperative period revealed complete occlusion of the right coronary artery. Due to the patient’s stability, we opted not to reintervene on the right coronary artery. The patient fully recovered without the need for further coronary intervention. In cases of patients with an aorto-ventricular tunnel More >

Ghazi A. Alshumrani^*

Congenital Heart Disease, Vol.19, No.2, pp. 197-206, 2024, DOI:10.32604/chd.2024.049401 - 16 May 2024

Abstract Objective: Coronary artery anatomical variations and anomalies are an important topic due to their potential clinical manifestations. This study aims to investigate the prevalence of coronary artery anatomical variations and anomalies in symptomatic patients with coronary computed tomography angiography (CCTA). Methods: This is a retrospective study that included all symptomatic patients who had CCTA in a tertiary care hospital in Saudi Arabia during a period of seven years. Results: The total number of included patients was 507 (60% males) with a mean age of 57.4 years. Approximately 41% had luminal stenoses, averaging 49.7%. The total number… More >

CHENYANG CHEN^1,*, JUAN WEN¹, WEI HUANG¹, JIANG LI^2,*

BIOCELL, Vol.47, No.11, pp. 2423-2433, 2023, DOI:10.32604/biocell.2023.044459 - 27 November 2023

Abstract Background: Pulmonary arterial hypertension (PAH) is a chronic and progressive disease that is strongly associated with dysregulation of glucose metabolism. Alterations in nuclear receptor subfamily 4 group A member 1 (NR4A1) activity alter the outcome of PAH. This study aimed to investigate the effects of NR4A1 on glycolysis in PAH and its underlying mechanisms. Methods: This study included twenty healthy volunteers and twenty-three PAH patients, and plasma samples were collected from the participants. To mimic the conditions of PAH in vitro, a hypoxia-induced model of pulmonary artery smooth muscle cell (PASMC) model was established. The proliferation… More > Graphic Abstract

Shota Kawai¹, Takashi Kido^1,*, Yuta Teguri¹, Koji Miwa¹, Tomomitsu Kanaya¹, Yoichiro Ishii², Hisaaki Aoki², Futoshi Kayatani², Sanae Tsumura¹

Congenital Heart Disease, Vol.18, No.4, pp. 399-411, 2023, DOI:10.32604/chd.2023.042243 - 15 September 2023

Abstract Objectives: We sought to determine the long-term outcomes and mortality-associated factors after systemic-to-pulmonary artery shunt (SPS) in patients with heterotaxy syndrome. Methods: We retrospectively analyzed all patients with a functional single ventricle and heterotaxy syndrome who underwent SPS at our center from January 2001 to April 2022. Results: This study involved 84 patients. Restrictive pulmonary blood flow requiring early modulation was presented in 34 (40%) patients. Compared with patients without restrictive pulmonary blood flow (N = 50 [60%]), the postnatal survival of these 34 patients was significantly lower at 10 years (log rank: p = 0.04),… More >

Sameh Abd El-Ghany^1,2, A. A. Abd El-Aziz^1,3,*

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 4633-4648, 2023, DOI:10.32604/cmc.2023.035779 - 31 March 2023

Abstract Coronary artery disease (CAD) is one of the most authentic cardiovascular afflictions because it is an uncommonly overwhelming heart issue. The breakdown of coronary cardiovascular disease is one of the principal sources of death all over the world. Cardiovascular deterioration is a challenge, especially in youthful and rural countries where there is an absence of human-trained professionals. Since heart diseases happen without apparent signs, high-level detection is desirable. This paper proposed a robust and tuned random forest model using the randomized grid search technique to predict CAD. The proposed framework increases the ability of CAD… More >

Kristina Krzelj^1,#,*, Irena Ivanac Vranesic^2,#, Kristina Maric Besic², Zeljko Duric¹, Darko Anic¹

Congenital Heart Disease, Vol.18, No.2, pp. 207-212, 2023, DOI:10.32604/chd.2023.027453 - 15 March 2023

Abstract Main pulmonary artery aneurysms are rare, mostly asymptomatic and discovered accidentally. The main pulmonary artery aneurysms may be idiopathic or secondary to underlying diseases such as pulmonary hypertension, Behcet’s disease, connective tissue disorders, congenital heart disease, vasculitis, syphilis, tuberculosis and endocarditis. There are some indices that dextrocardia is associated with anomalies of the pulmonary arteries and pulmonary valve. A rare occurrence of main pulmonary artery aneurysms results in a lack of recommendations, so the remaining challenges are whether main pulmonary artery aneurysms should be treated, how, and when. The decision on surgical intervention or conservative More > Graphic Abstract

Andrei George Iosifescu^1,2,*, Roxana Enache^1,3, Ioana Marinică⁴, Corina Radu², Vlad Anton Iliescu^1,2

Congenital Heart Disease, Vol.18, No.1, pp. 67-72, 2023, DOI:10.32604/chd.2023.026598 - 09 January 2023

Abstract Left main coronary compression syndrome (LMCS) may complicate pulmonary artery aneurysms (PAA), usually developed in the context of pulmonary arterial hypertension (PAH). We report the case of a 51-year-old female patient with an atrial septal defect (unsuitable for device closure) complicated by a PAA generating a 90% left main stenosis. The significant PAH held us back from immediate surgery. After specific dual PAH-targeted therapy (sildenafil and bosentan), the atrial septal defect could be closed with a unidirectional valved patch; the PAA-induced LMCS was treated by reductive arterioplasty. The postoperative course was uneventful. Follow-up showed clinical More > Graphic Abstract