Jane W. Newburger
Congenital Heart Disease, Vol.12, No.5, pp. 633-635, 2017, DOI:10.1111/chd.12498
Abstract Kawasaki disease is an acute febrile arteritis of childhood that can result in coronary artery aneurysms if untreated in the first 10 and ideally 7 days of illness. Kawasaki disease begins as a
necrotizing arteritis with neutrophilic infiltrate, followed by subacute/chronic changes and luminal
myofibroblastic proliferation that can cause coronary artery stenosis. Manifestations include the
presence of ≥5 days of fever, together with clinical criteria of extremity changes, rash, conjunctivitis, oral changes, and unilateral cervical lymphadenopathy. Echocardiography should be performed
at the time of diagnosis, then 1–2 weeks and 4–6 weeks later, with more frequent More >
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