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  • Open Access

    ARTICLE

    Bioactive Potential of Calophyllum inophyllum: Phytochemical Profiles, Biological Activities, and In Silico Pharmacokinetic Predictions

    Luksamee Vittaya1,*, Chakhriya Chalad1, Sittichoke Janyong2, Nararak Leesakul3

    Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 4091-4115, 2025, DOI:10.32604/phyton.2025.074891 - 29 December 2025

    Abstract Calophyllum inophyllum is a tropical plant that could have useful medicinal properties for pharmaceutical and cosmetic applications. The present study extracted the flower, fruit, leaf, twig, and bark of the plant by maceration in different organic solvents. The correlation between bioactive compounds and their biological activities was investigated, with emphasis on their therapeutic relevance through in silico pharmacokinetic predictions using SwissADME. Qualitative and quantitative analyses were conducted to determine the total phenolic, flavonoid, and saponin contents of the extracts. Spectral analysis of the extracts revealed –OH, C=O, C=C, and C–H functional groups. The antioxidant activity of the… More > Graphic Abstract

    Bioactive Potential of <i>Calophyllum inophyllum</i>: Phytochemical Profiles, Biological Activities, and <i>In Silico</i> Pharmacokinetic Predictions

  • Open Access

    ARTICLE

    Synergistic Effects of Melatonin and Methyl Jasmonate in Mitigating Drought-Induced Oxidative Stress in Common Bean (Phaseolus vulgaris)

    Totan Kumar Ghosh1, Md. Roushonuzzaman Rakib1, Munna1, S. M. Zubair AL-Meraj1, Md. Moshiul Islam2, Anika Nazran1, Mohammad Golam Mostofa3,*

    Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3925-3943, 2025, DOI:10.32604/phyton.2025.073382 - 29 December 2025

    Abstract The productivity of common bean (Phaseolus vulgaris L.), an economically important legume, is severely hindered by drought stress. While melatonin (Mel) and methyl jasmonate (MeJA) are known to alleviate abiotic stresses, their combined effects in mitigating drought-induced oxidative stress are unknown. Here, we examined the synergistic effects of Mel and MeJA in alleviating drought-associated oxidative damage in common bean. Compared with well-watered controls, drought stress caused a significant decline in plant biomass, photosynthetic pigments, and photosystem II efficiency (Fv/Fm). Drought also significantly increased hydrogen peroxide (H2O2) accumulation, which likely contributed to membrane lipid peroxidation, as indicated by… More >

  • Open Access

    ARTICLE

    Chitosan-Selenate Complex Improves Bioactive Profile and Antioxidant Response in Wheat Sprouts (Triticum aestivum L.)

    Jazmín Montserrat Gaucin-Delgado1, Cristian Oswaldo Solis-López2, Pablo Preciado-Rangel3, Bernardo Espinosa-Palomeque4, Francisco Gerardo Veliz-Deras2, Viridiana Contreras-Villarreal2, Ricardo Israel Ramírez-Gottfried5,*

    Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3961-3973, 2025, DOI:10.32604/phyton.2025.072536 - 29 December 2025

    Abstract Selenium (Se) deficiency is a global health problem affecting more than 500 million people; crop biofortification is a sustainable strategy for its mitigation. This study investigated the effect of the application of selenate nanoparticles (SeO42−) and the combination of selenate (SeO42−) and chitosan (CS) (forming a SeO42−-CS complex) on the antioxidant profile, growth, biomass, bioactive compounds, enzymes, and Se accumulation of wheat (Triticum spp.) sprouts. Fourteen treatments were applied using a factorial design combining seven concentrations and two formulations: SeO42− and SeO42−-CS. It was identified that chitosan increased Se uptake efficiency by 30% versus conventional selenate. The optimal… More >

  • Open Access

    ARTICLE

    Effect of Supplementation Time and Selenium Chemical Form on the Efficiency of Dandelion Biofortification

    Nadezhda Golubkina1,*, Pavel Poluboyarinov2, Lyubov Skrypnik3, Agnieszka Sękara4, Otilia Cristina Murariu5, Gianluca Caruso6

    Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3861-3877, 2025, DOI:10.32604/phyton.2025.070988 - 29 December 2025

    Abstract Circadian biorhythms are fundamental in plant adaptability and development. To reveal the effect of organic and inorganic forms of Se, foliar treatments of dandelion with 0.26 mM Se solutions were practiced in two contrasting day times: in the morning with the highest levels of leaf Se and polyphenol (TP) and the lowest dry matter, and in the evening with the opposite characteristics. Compared to the control, the morning Se supply demonstrated a higher increase of root biomass (1.27–1.37 times), Se (1.82–2.85 times), TP content (1.42–1.44 times), and antioxidant activity (AOA) (1.47–1.48 times) than the evening… More > Graphic Abstract

    Effect of Supplementation Time and Selenium Chemical Form on the Efficiency of Dandelion Biofortification

  • Open Access

    REVIEW

    Mitochondrial Stress, Melatonin, and Neurodegenerative Diseases: New Nanopharmacological Approaches

    Virna Margarita Martín Giménez1, SebastiáN GarcíA MenéNdez2,3, Luiz Gustavo A. Chuffa4, Vinicius Augusto SimãO4, Russel J. Reiter5, Ramaswamy Sharma6, Walter Balduini7, Carla Gentile8, Walter Manucha2,3,*

    BIOCELL, Vol.49, No.12, pp. 2245-2282, 2025, DOI:10.32604/biocell.2025.071830 - 24 December 2025

    Abstract Neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) are characterized by progressive neuronal loss, which is closely linked to mitochondrial dysfunction. These pathologies involve a complex interplay of genetics, protein misfolding, and cellular stress, culminating in impaired energy metabolism, an increase in reactive oxygen species (ROS), and defective mitochondrial quality control. The accumulation of damaged mitochondria and dysregulation of pathways such as the Integrated Stress Response (ISR) are central to the pathogenesis of these conditions. This review explores the critical relationship between mitochondrial stress… More >

  • Open Access

    ARTICLE

    Highly Pure Water-Soluble Aspen Wood Hemicelluloses Derived by Catalytic Peracetic Treatment and Their Antioxidant and Flocculation Activity

    Valentina Sergeevna Borovkova1,2,*, Yuriy Nikolaevich Malyar1,2, Vladislav Alexandrovich Ionin1,2, Alexander Sergeevich Kazachenko1,2

    Journal of Renewable Materials, Vol.13, No.12, pp. 2281-2296, 2025, DOI:10.32604/jrm.2025.02025-0067 - 23 December 2025

    Abstract The valorization of plant biomass towards high-value chemicals is a global trend aimed at solving the problem of the huge accumulation of lignocellulosic waste. Plant polysaccharides are natural polymers that make up about 20% by weight of biomass, with a unique variety of structures and properties that depend on the type of raw materials and the method of their extraction. In this study, the effect of variability of the oxidative delignification process conditions in the «acetic acid-hydrogen peroxide-water-(NH4)6Mo7O24» on the extraction and properties of aspen (Populus tremula) wood hemicelluloses was investigated for the first time. The developed… More > Graphic Abstract

    Highly Pure Water-Soluble Aspen Wood Hemicelluloses Derived by Catalytic Peracetic Treatment and Their Antioxidant and Flocculation Activity

  • Open Access

    ARTICLE

    Enhancing anticancer, antioxidant, and antibacterial activities of chalcogen-based SnSe nanoparticles synthesized through the co-precipitation method

    H. A. Rather1,*, J. B. A. Wahid2, M. A. Dar3, L. Guganathan4, U. A. Dar5, P. Arularasan6, S. E. I. Yagoub7, L. G. Amin7

    Chalcogenide Letters, Vol.22, No.5, pp. 461-468, 2025, DOI:10.15251/CL.2025.225.461

    Abstract SnSe powdered nanoparticles (NPs) are prepared using the co-precipitation method. The powdered NPs were studied using X-ray diffraction (XRD), UV-absorbance spectroscopy, and scanning electron microscopy (SEM) characterization techniques. The XRD result indicates that NPs are orthorhombic with a crystalline size of 4 nm for TS-1, 6 nm for TS-2, and 13 nm for TS-3, respectively. The SEM images show the surface morphology of the prepared NPs is not fully spherical, but semi-flower-like. The optical properties of the powdered NPs are found by UV-Vis absorbance spectroscopy, in which the highest absorbance was found between 200 nm More >

  • Open Access

    ARTICLE

    Melatonin Enhances Antioxidant Defense and Physiological Stability in Grapevine (Vitis vinifera L.) Cultivars ‘Merlot’ and ‘Erciş’ under UV-B Stress

    Sena Yıldız1, Nurhan Keskin2,*, Birhan Kunter3, Harlene Hatterman-Valenti4, Ozkan Kaya4,5,*

    Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3471-3492, 2025, DOI:10.32604/phyton.2025.073180 - 01 December 2025

    Abstract Climate change-driven environmental stresses, particularly ultraviolet-B (UV-B) radiation, pose severe threats to grapevine (Vitis vinifera L.) productivity and physiological stability. This study investigated the protective role of melatonin in in vitro plantlets of two grapevine cultivars, ‘Merlot’ and ‘Erciş’, subjected to low (≈8.25 μW cm−2, 16 h) and high (≈33 μW cm−2, 4 h) UV-B exposure. Significant cultivar-specific responses were observed (p < 0.001). The ‘Erciş’ cultivar exhibited higher oxidative stress, with malondialdehyde (MDA) levels reaching 24.30 mmol g−1 FW in control plants compared with 14.91 ± 0.25 mmol g−1 FW in ‘Merlot’. Melatonin provided dose-dependent mitigation, reducing MDA to… More >

  • Open Access

    ARTICLE

    Valorisation of Northern Moroccan Centaurium erythraea: Targeted Phytochemistry, Antioxidant, Antimicrobial Efficacy and Drug Likeness Benchmarking

    Yousra Hammouti1,2,*, François Mesnard2, Oussama Khibech3, Mohamed Taibi1, Yousra Belbachir3, El Hassania Loukili4, Reda Bellaouchi5, Abdeslam Asehraou5, Mohamed Addi1,*

    Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3563-3583, 2025, DOI:10.32604/phyton.2025.071139 - 01 December 2025

    Abstract Centaurium erythraea Rafn (“Gosset El Haya”) has long been prized in North African folk medicine, yet Moroccan chemobiological data remain scarce. Ethanol extracts of northern Moroccan aerial parts were profiled by high-performance liquid chromatography (HPLC) and found rich in phenolics, dominated by 4-hydroxybenzoic acid (57.8%) and naringin (10.3%). The extract exhibited strong antioxidant power in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay, with a half-maximal inhibitory concentration (IC50) of ≈74 µg mL−1, and a total antioxidant capacity (TAC) of ≈201 µg mL−1 and selective antimicrobial activity, sharply inhibiting Aspergillus niger, Penicillium digitatum, and Rhodotorula glutinis while sparing Staphylococcus aureus. In-silico absorption, distribution, metabolism,… More >

  • Open Access

    ARTICLE

    Zinc Oxide Nanoparticle Alleviates the Inhibition of Dendrobium huoshanense Photosynthesis by Cadmium through Enhancing Antioxidant Enzyme System

    Cheng Song1,*, Iftikhar Hussein Shah2, Ghulam Abbas Ashraf3, Muhammad Arif4, Muhammad Aamir Manzoor1,5,*

    Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3427-3451, 2025, DOI:10.32604/phyton.2025.070778 - 01 December 2025

    Abstract Heavy metal pollution has become a pervasive environmental issue affecting numerous regions worldwide. Recently, there has been significant attention given to the application of nano-enabled technologies with the purpose of enhancing plant development and alleviating heavy metal stress. This study aimed to illustrate the potential of zinc oxide nanoparticles (ZnO-NPs) to enhance the morphological traits of D. huoshenense exposed to cadmium (Cd) stress. The chemical structure and elemental composition of the ZnO-NPs were characterised by a series of analytical methods, including X-ray diffraction, UV-Vis spectrometry, XPS, and TEM. Plant samples used were collected at 0, 5,… More > Graphic Abstract

    Zinc Oxide Nanoparticle Alleviates the Inhibition of <i>Dendrobium huoshanense</i> Photosynthesis by Cadmium through Enhancing Antioxidant Enzyme System

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