William Daly^*, Daniel Pelzman, P. Dafe Ogagan, Stephen V. Jackman

Canadian Journal of Urology, Vol.32, No.6, pp. 669-672, 2025, DOI:10.32604/cju.2025.063778 - 30 December 2025

Abstract Background: Minor bleeding after prostate biopsy is a relatively common complication, but clinically significant hemorrhage happens rarely. Management of prostatic artery pseudoaneurysm has not been described in the literature. Case Description: In this case, an 84-year-old man presented after prostate biopsy with rectal bleeding and required a massive transfusion. Ultimately, he was found to have a prostatic artery pseudoaneurysm, which to our knowledge is heretofore undescribed after prostate biopsy. Bleeding ultimately stopped spontaneously as the patient deferred angioembolization. He had not recurrent bleeding on follow up but is still deciding on treatment course for newly diagnosed More >

Ji Lam Leong, Sivakumar Sivalingam^*

Congenital Heart Disease, Vol.20, No.3, pp. 341-346, 2025, DOI:10.32604/chd.2025.066461 - 11 July 2025

Abstract Left atrial aneurysm is an exceptionally rare condition, particularly in the pediatric population, and even more so as a sequela of bacterial pericarditis. We present the case of a 16-month-old girl who developed a left atrial aneurysm following isolated Staphylococcus aureus pericarditis. She initially presented in decompensated shock and was later diagnosed with constrictive pericarditis. Despite undergoing pericardiectomy, she subsequently developed a left atrial aneurysm, necessitating surgical closure. This case highlights the aggressive nature of bacterial pericarditis and its potential to cause rare structural cardiac complications. More >

Wilhelm Mistiaen^*

Congenital Heart Disease, Vol.20, No.3, pp. 305-323, 2025, DOI:10.32604/chd.2025.064675 - 11 July 2025

Abstract The presence of a bicuspid aortic valve (BAV) is the most common congenital heart anomaly, which can remain asymptomatic for decades, if it is not a part of a syndrome, such as Turner syndrome or genetic connective tissue disorders. There are several classifications for BAV, each with its advantages and drawbacks. The condition can lead to valvular malfunction such as regurgitation and stenosis, but is often associated with dilatation of the aortic root, the ascending aorta, the aortic arch, or a combination. Altered flow patterns due to the valve dysfunction as well as the breakdown… More >

Yaqi Zhang^1,#, Liang Hu^1,#, Yuxi Zhang¹, Bo Qian¹, Jirong Qi^1,2, Wei Peng^1,2,*

Congenital Heart Disease, Vol.20, No.1, pp. 55-60, 2025, DOI:10.32604/chd.2025.063072 - 18 March 2025

Abstract Background: Carotid artery pseudoaneurysm in children is rare; typically caused by trauma; surgical interventions and infection. These aneurysms can lead to significant neurological and vascular risks; and their management remains challenging. While endovascular therapy has become the standard for giant pseudoaneurysms in adults; its use in children is limited. No established guidelines or long-term safety data exist for pediatric endovascular treatment. We present a child who developed a carotid artery pseudoaneurysm after venoarterial extracorporeal membrane oxygenation (VA-ECMO) support and heart transplantation; highlighting the management strategies and outcomes. Case Description: A 4-year-old boy with dilated cardiomyopathy was admitted… More >

Yücel Kaya^1,*, And Yavuz¹, Hasan Berkan Sayal¹, Büşra Tsakir¹, Gökalp Kabacaoğlu¹, Kadriye Nilay Özcan²

Congenital Heart Disease, Vol.19, No.1, pp. 123-129, 2024, DOI:10.32604/chd.2024.048145 - 20 March 2024

Abstract Congenital ventricular aneurysm is a very rare cardiac anomaly. A diagnosis can be made during the prenatal period using fetal echocardiography. This study presents a very rare apically located left ventricular aneurysm case, and the relevant literature was reviewed and discussed. In this case, a 35-year-old, gravida 2, parity 1 pregnant woman at 24 weeks of gestation, displayed a wide aneurysmal image in the left ventricular apical wall on fetal echocardiography. There was a 1.79 mm muscular ventricular septal defect at the apical region of the interventricular septum. In the course of the color Doppler More >

WEI ZHENG¹, CHENG LIU^2,*

BIOCELL, Vol.48, No.2, pp. 293-301, 2024, DOI:10.32604/biocell.2023.044211 - 23 February 2024

Abstract Objective: Intracranial aneurysm (IA) represents a devastating disease with high rates of disability and mortality, which is initiated by dysfunction of endothelial cells (ECs). Evidence suggests the dysregulation of the E3 ubiquitin ligase family during EC injury. In this work, the role of an E3 ubiquitin ligase, casitas B lymphoma-B (CBL-B), was explored in human brain microvascular EC (HBMEC) function through the NLRP3 pathway. Methods: In vitro IA model was induced by treating HBMECs with oxidized low-density lipoprotein (ox-LDL). The levels of CBL-B and pyroptosis-related proteins NLRP3, ASC, cleaved caspase-1, and GSDME-N were determined by real-time-quantitative… More >

Kristina Krzelj^1,#,*, Irena Ivanac Vranesic^2,#, Kristina Maric Besic², Zeljko Duric¹, Darko Anic¹

Congenital Heart Disease, Vol.18, No.2, pp. 207-212, 2023, DOI:10.32604/chd.2023.027453 - 15 March 2023

Abstract Main pulmonary artery aneurysms are rare, mostly asymptomatic and discovered accidentally. The main pulmonary artery aneurysms may be idiopathic or secondary to underlying diseases such as pulmonary hypertension, Behcet’s disease, connective tissue disorders, congenital heart disease, vasculitis, syphilis, tuberculosis and endocarditis. There are some indices that dextrocardia is associated with anomalies of the pulmonary arteries and pulmonary valve. A rare occurrence of main pulmonary artery aneurysms results in a lack of recommendations, so the remaining challenges are whether main pulmonary artery aneurysms should be treated, how, and when. The decision on surgical intervention or conservative More > Graphic Abstract

Andrei George Iosifescu^1,2,*, Roxana Enache^1,3, Ioana Marinică⁴, Corina Radu², Vlad Anton Iliescu^1,2

Congenital Heart Disease, Vol.18, No.1, pp. 67-72, 2023, DOI:10.32604/chd.2023.026598 - 09 January 2023

Abstract Left main coronary compression syndrome (LMCS) may complicate pulmonary artery aneurysms (PAA), usually developed in the context of pulmonary arterial hypertension (PAH). We report the case of a 51-year-old female patient with an atrial septal defect (unsuitable for device closure) complicated by a PAA generating a 90% left main stenosis. The significant PAH held us back from immediate surgery. After specific dual PAH-targeted therapy (sildenafil and bosentan), the atrial septal defect could be closed with a unidirectional valved patch; the PAA-induced LMCS was treated by reductive arterioplasty. The postoperative course was uneventful. Follow-up showed clinical More > Graphic Abstract

Yifan Li¹, Zewen Chen², Jian Zhuang², Zhiwei Zhang^1,*

Congenital Heart Disease, Vol.17, No.5, pp. 541-549, 2022, DOI:10.32604/chd.2022.024907 - 06 September 2022

Abstract A congenital coronary artery fistula (CCAF) combined with giant coronary aneurysm (CAA) is a rare congenital cardiac abnormality. We reported an 8-year-old patient who underwent transcatheter closure of both inlet and outlet of a proximal left coronary artery (LCA)-to-left ventricular (LV) fistula with CAA of 41 mm × 28 mm in diameter, during which acute occlusion of left anterior descending coronary artery (LAD) occurred immediately after device implantation at the inlet of fistula. We managed to prevent the patient from major adverse cardiac events by conservative therapy with dual antiplatelet agents instead of surgical removal More > Graphic Abstract

V. Sudha^1,*, T. R. Ganeshbabu²

CMC-Computers, Materials & Continua, Vol.66, No.1, pp. 827-842, 2021, DOI:10.32604/cmc.2020.012008 - 30 October 2020

Abstract Diabetic Retinopathy (DR) is a type of disease in eyes as a result of a diabetic condition that ends up damaging the retina, leading to blindness or loss of vision. Morphological and physiological retinal variations involving slowdown of blood flow in the retina, elevation of leukocyte cohesion, basement membrane dystrophy, and decline of pericyte cells, develop. As DR in its initial stage has no symptoms, early detection and automated diagnosis can prevent further visual damage. In this research, using a Deep Neural Network (DNN), segmentation methods are proposed to detect the retinal defects such as… More >