ZHEN LIU^1,#, LIANGWANG YANG^2,#, ZHENGXING XIE¹, HUI YU³, TIANYI GU³, DAOMING SHI⁴, NING CAI^1,*, SHENGHUA ZHUO^2,*

Oncology Research, Vol.32, No.5, pp. 965-981, 2024, DOI:10.32604/or.2024.045769

Abstract Clinical data indicates that glioma patients have poor treatment outcomes and clinical prognosis. The role of olfactory signaling pathway-related genes (OSPRGs) in glioma has not been fully elucidated. In this study, we aimed to investigate the role and relationship between OSPRGs and glioma. Univariate and multivariate Cox regression analyses were performed to assess the relationship between OSPRGs and the overall survival of glioma based on public cohorts, and the target gene (G Protein Subunit Alpha L, GNAL) was screened. The association of GNAL expression with clinicopathological characteristics, gene mutation landscape, tumor immune microenvironment (TIME), deoxyribonucleic acid (DNA) methylation, and naris-occlusion… More >

JINGJING CHEN¹, DAN WANG², ZEQUN WANG², MENGYUAN HAN⁴, HOUQING YIN², WENTING ZHOU⁴, RIBAI YAN⁵, YAN PAN^2,3,*

Oncology Research, Vol.32, No.5, pp. 911-923, 2024, DOI:10.32604/or.2023.042384

Abstract Photodynamic therapy (PDT) is a promising cancer treatment. This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−10,15,20-triphenyl-porphyrin (DTP) mediated PDT (DTP-PDT). Cell viability, reactive oxygen species (ROS), and apoptosis were measured with a Cell Counting Kit-8 assay, DCFH-DA fluorescent probe, and Hoechst staining, respectively. Cell apoptosis- and autophagy-related proteins were examined using western blotting. RNA sequencing was used to screen differentially expressed mRNAs (DERs), and bioinformatic analysis was performed to identify the major biological events after DTP-PDT. Our results show that DTP-PDT inhibited cell growth and induced ROS generation in MCF-7 and SGC7901… More > Graphic Abstract

Yiyi Cen^1,3, Wenzheng Jia², Wen Dai^3,*, Chun Wang⁴, He Wu¹

Revue Internationale de Géomatique, Vol.33, pp. 93-109, 2024, DOI:10.32604/rig.2024.050273

Abstract Color, as a significant element of village landscapes, serves various functions such as enhancing aesthetic appeal and attractiveness, conveying emotions and cultural values. To explore the three-dimensional spatial characteristics of color landscapes in beautiful villages, this study conducted a comparative experiment involving eight provincial-level beautiful villages and eight ordinary villages in Jinzhai County. Landscape pattern indices were used to analyze the color landscape patterns on the facades of these villages, complemented by a quantitative analysis of color attributes using the Munsell color system. The results indicate that (1) Natural landscape colors in beautiful villages are primarily concentrated in the yellow-red… More >

Chengbao Hu^1,2,3, Shilin Gong^4,*, Bin Chen^1,2,3, Zhongling Zong⁴, Xingwang Bao⁵, Xiaojian Ru⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 997-1015, 2024, DOI:10.32604/cmes.2024.048640

Abstract Strain localization frequently occurs in cohesive materials with friction (e.g., composites, soils, rocks) and is widely recognized as a fundamental cause of progressive structural failure. Nonetheless, achieving high-fidelity simulation for this issue, particularly concerning strong discontinuities and tension-compression-shear behaviors within localized zones, remains significantly constrained. In response, this study introduces an integrated algorithm within the finite element framework, merging a coupled cohesive zone model (CZM) with the nonlinear augmented finite element method (N-AFEM). The coupled CZM comprehensively describes tension-compression and compression-shear failure behaviors in cohesive, frictional materials, while the N-AFEM allows nonlinear coupled intra-element discontinuities without necessitating extra nodes or… More >

Zibin Mao¹, Qinghai Zhao^1,2,*, Liang Zhang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 757-792, 2024, DOI:10.32604/cmes.2024.048016

Abstract This paper proposes a multi-material topology optimization method based on the hybrid reliability of the probability-ellipsoid model with stress constraint for the stochastic uncertainty and epistemic uncertainty of mechanical loads in optimization design. The probabilistic model is combined with the ellipsoidal model to describe the uncertainty of mechanical loads. The topology optimization formula is combined with the ordered solid isotropic material with penalization (ordered-SIMP) multi-material interpolation model. The stresses of all elements are integrated into a global stress measurement that approximates the maximum stress using the normalized p-norm function. Furthermore, the sequential optimization and reliability assessment (SORA) is applied to… More >

Fatma Nese Efil¹, Sania Qureshi^1,2,3, Nezihal Gokbulut^1,4, Kamyar Hosseini^1,3, Evren Hincal^1,4,*, Amanullah Soomro²

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 485-512, 2024, DOI:10.32604/cmes.2024.047907

Abstract The global population has been and will continue to be severely impacted by the COVID-19 epidemic. The primary objective of this research is to demonstrate the future impact of COVID-19 on those who suffer from other fatal conditions such as cancer, heart disease, and diabetes. Here, using ordinary differential equations (ODEs), two mathematical models are developed to explain the association between COVID-19 and cancer and between COVID-19 and diabetes and heart disease. After that, we highlight the stability assessments that can be applied to these models. Sensitivity analysis is used to examine how changes in certain factors impact different aspects… More >

Hung-Hsiang Wang¹, Chih-Ping Chen^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 685-709, 2024, DOI:10.32604/cmes.2024.047630

Abstract This paper presents a new method of using a convolutional neural network (CNN) in machine learning to identify brand consistency by product appearance variation. In Experiment 1, we collected fifty mouse devices from the past thirty-five years from a renowned company to build a dataset consisting of product pictures with pre-defined design features of their appearance and functions. Results show that it is a challenge to distinguish periods for the subtle evolution of the mouse devices with such traditional methods as time series analysis and principal component analysis (PCA). In Experiment 2, we applied deep learning to predict the extent… More >

Hayder Kareem Sakran^1,2, Mohd Sharizal Abdul Aziz^1,*, Chu Yee Khor³

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 109-137, 2024, DOI:10.32604/cmes.2024.047245

Abstract The centrifugal pump is a prevalent power equipment widely used in different engineering patterns, and the impeller blade wrap angle significantly impacts its performance. A numerical investigation was conducted to analyze the influence of the blade wrap angle on flow characteristics and energy distribution of a centrifugal pump evaluated as a low specific speed with a value of 69. This study investigates six impeller models that possess varying blade wrap angles (95°, 105°, 115°, 125°, 135°, and 145°) that were created while maintaining the same volute and other geometrical characteristics. The investigation of energy loss was conducted to evaluate the… More > Graphic Abstract

Qi Zhang^1,2,4,5, Zhixin Chen³, Yang Wu^4,*, Guoqi Xiang², Guang Wen¹, Xuegang Zhang², Yongchun Xie², Guangchun Yang²

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 593-619, 2024, DOI:10.32604/cmes.2023.046319

Abstract Although there is currently no unified standard theoretical formula for calculating the contact stress of cylindrical gears with a circular arc tooth trace (referred to as CATT gear), a mathematical model for determining the contact stress of CATT gear is essential for studying how parameters affect its contact stress and building the contact stress limit state equation for contact stress reliability analysis. In this study, a mathematical relationship between design parameters and contact stress is formulated using the Kriging Metamodel. To enhance the model’s accuracy, we propose a new hybrid algorithm that merges the genetic algorithm with the Quantum Particle… More >

Umer Nauman¹, Yuhong Zhang², Zhihui Li³, Tong Zhen^1,3,*

Journal of Intelligent Medicine and Healthcare, Vol.2, pp. 15-34, 2024, DOI:10.32604/jimh.2024.048784

Abstract The convergence of handheld devices and cloud-based computing has transformed how Electronic Health Records (EHRs) are stored in mobile cloud paradigms, offering benefits such as affordability, adaptability, and portability. However, it also introduces challenges regarding network security and data confidentiality, as it aims to exchange EHRs among mobile users while maintaining high levels of security. This study proposes an innovative blockchain-based solution to these issues and presents secure cloud storage for healthcare data. To provide enhanced cryptography, the proposed method combines an enhanced Blowfish encryption method with a new key generation technique called Elephant Herding Optimization with Resistance-Based Training (EHO-RBT).… More >