Sarra B. Shakartalla^1,2,3, Iman M. Talaat^1,2,4,*, Nival Ali¹, Shahenaz S. Salih^1,5, Zainab M. Al Shareef^1,2, Noura Alkhayyal⁶, Riyad Bendardaf^2,7,*, Sameh S. M. Soliman^1,8,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070808 - 30 December 2025

Abstract Objectives: Breast cancer (BC) is the leading cause of cancer-related mortality in women, largely due to metastasis. This study aims to explore the role of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism, in the aggressiveness and metastatic behavior of BC. Methods: A comprehensive analysis was performed using in silico transcriptomic data (n = 2509 patients), immunohistochemical profiling of BC tissues (n = 103), and validation through western blotting in multiple BC cell lines. Gene expression and survival analyses were conducted using Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and… More >

MELISSA SáNCHEZ-RODRíGUEZ^1,2, ROBERTO LAZZARINI-LECHUGA³, VERóNICA SOUZA-ARROYO^1,4, LETICIA BUCIO-ORTIZ^1,4, ROXANA U. MIRANDA-LABRA^1,4, MONSERRAT GERARDO-RAMíREZ¹, ARACELI PáEZ-ARENAS⁵, MOISES VERGARA-MENDOZA⁶, MARíA CONCEPCIóN GUTIéRREZ-RUIZ^1,4, ALEJANDRO ESCOBEDO-CALVARIO^1,2,*, LUIS E. GOMEZ-QUIROZ^1,4,*

Oncology Research, Vol.33, No.8, pp. 2075-2084, 2025, DOI:10.32604/or.2025.064899 - 18 July 2025

Abstract Background: Growth differentiation factor 11 (GDF11), a transforming growth factor-beta superfamily member, is a crucial protein involved in many differentiation processes in embryogenesis and morphogenesis, and it has been extensively characterized due to its capacity to target poorly differentiated cells, including transformed or cancer cells. Aim: In the present work, we aimed to describe the effects on migration, proliferation, and metabolism in the T-cell acute lymphoblastic leukemia-derived cell line Jurkat. Methods: Based on previous evidence, we analyzed metabolic changes exerted by GDF11 and its relationship with the aggressive phenotype. Results: We found a profound impact on More >

Xuezhi Liu^1,2, Jianxiao Wu³, Lingjing Guo⁴, Ronghuan Wang⁵, Qiang Yang¹, Baojuan Ye^1,*, Xiufeng Guo⁶

International Journal of Mental Health Promotion, Vol.27, No.3, pp. 303-318, 2025, DOI:10.32604/ijmhp.2025.060117 - 31 March 2025

Abstract Objectives: The aim of this study was to verify the causal relationship between trait aggressiveness (TA) and moral disengagement (MD), know more about the growth trajectory of MD, and explore the effects of gender and TA on the growth trajectory. Methods: We used the Buss-Perry Aggression Questionnaire and Moral Disengagement Scale to survey 433 Chinese junior high school students longitudinally three times. Results: The results of the random intercept cross-lagged panel model (RI-CLPM) analysis indicated that TA positively predicted MD, while MD did not predict TA at the within-person level. Thus, TA could be considered an… More >

Salah Hadjout^1,2,*, Mohamed Zouidi¹, Houcine Bougrine¹, Abdeldjalil Belkendil¹, Amer Zeghmar¹, Walid Ouaret³, Walid Soufan⁴, Fathi Abdellatif Belhouadjeb⁵

Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 2983-2992, 2024, DOI:10.32604/phyton.2024.056982 - 30 November 2024

Abstract Fusarium head blight (FHB) is a disease caused by several Fusarium species, notably, F. culmorum and F. graminearum. These pathogens adversely affect the technological and sanitary qualities of cereal grains, particularly durum wheat. Under favorable environmental conditions and in susceptible varieties, these Fusarium species can significantly reduce both the quantity and quality of crops. This study evaluated the pathogenicity of the two Fusarium species (FC2006 and FG2008) in the growth of durum wheat coleoptiles. The plant material included four commercially grown parental varieties (G9, G10, G11, G12) and eight breeding lines (G1, G2, G3, G4, G5, G6, G7, G8).… More >

Si Yu¹, Chunyang Zhang², Yijun Lin¹, Qian Zhang³, Wei Xu^1,*

International Journal of Mental Health Promotion, Vol.22, No.2, pp. 71-81, 2020, DOI:10.32604/IJMHP.2020.011194 - 16 June 2020

Abstract Few studies have comprehensively explored the mechanism of the association between dispositional mindfulness and the process of internalization and externalization. Given that dispositional mindfulness can enhance the level of self-acceptance, the present study investigated the role of self-compassion in the effect of dispositional mindfulness on anxiety and aggressiveness among college students with left-behind experience (LBE). A total of 385 Chinese college students with LBE reported their level of dispositional mindfulness, anxiety symptoms, aggressiveness, and self-compassion. Dispositional mindfulness was negatively associated with anxiety and aggressiveness after controlling for gender, age, and whether they are the only More >

Sukru Gulluoglu^*†, Mesut Sahin^‡, Emre Can Tuysuz^†, Cumhur Kaan Yaltirik^§, Aysegul Kuskucu^*, Ferda Ozkan^¶, Fikrettin Sahin^†, Ugur Ture^§, Omer Faruk Bayrak^*

Oncology Research, Vol.25, No.7, pp. 1177-1188, 2017, DOI:10.3727/096504017X14874349473815

Abstract Chordomas are rare tumors of the spine and skull base that are locally destructive and resistant to chemotherapy and radiation therapy, with a poor prognosis and limited therapeutic options. Chordoma patients have a long life expectancy with high mortality from the disease. Cancer stem cells, which are known to exist in chordomas, have extensive proliferative and self-renewal potential and are responsible for maintaining tumor heterogeneity along with chemotherapy and radiotherapy resistance. Leukemia inhibitory factor (LIF) has multiple functions in stem cell biology, the immune response, and cancer, and is potentially a key molecule that allows… More >

Elijah O. Kehinde¹, May Al Maghrebi², Jehoram T. Anim³

Canadian Journal of Urology, Vol.15, No.2, pp. 3967-3974, 2008

Abstract Incidental prostate cancer (PCa) has been demonstrated at autopsy in about 80% of men aged 80 years and above and also in 10%-15% of younger men aged 30-50 years in the United States. These data imply a wide variation in aggressiveness of prostate cancer, from indolent tumors to aggressive cancers that kill the patients. The use of prostate specific antigen (PSA) in screening for PCa may detect even indolent disease for which radical prostatectomy may not be necessary. Currently available criteria such as histological grade, PSA level, stage of the disease do not always predict… More >