Hiba Alzoubi1, Alameen Alsabbah2, Rosario Caltabiano3, Giuseppe Broggi3,*
Oncologie, Vol.24, No.1, pp. 51-63, 2022, DOI:10.32604/oncologie.2022.020890
- 31 March 2022
Abstract The 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS)
improved our understanding of the brain neoplasm biology. In more details, differences between diffuse gliomas
that primarily occur in adults and those that primarily occur in children have been identified by the terms “adult-type” and “pediatric-type” diffuse gliomas. More importantly, both diagnostic and grading criteria for adult-type
diffuse astrocytomas have been modified, by adopting novel molecular markers: diffuse astrocytomas, IDH-mutant have been grouped into a single entity and graded as CNS WHO grades 2, 3, or 4, with the assignment
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