Hai-tao Geng^*, Rui-juan Cao^*, Lei Cheng^†, Chun-yuan Liu^†

Oncology Research, Vol.25, No.7, pp. 1039-1046, 2017, DOI:10.3727/096504016X14813914187138

Abstract Hepatocyte cell adhesion molecule (hepaCAM), a new type of CAM, belongs to the immunoglobulin superfamily. Recently, hepaCAM was reported to be implicated in cancer development, and many researchers investigated its biological function in the tumorigenesis of various cancers. However, what kind of role hepaCAM plays in colorectal cancer (CRC) remains unknown. In this study, we found that hepaCAM was downregulated in CRC tissues and cell lines. Overexpression of hepaCAM inhibited CRC cell proliferation, migration, and invasion in vitro. Furthermore, the tumorigenesis assay showed that increased expression of hepaCAM suppressed CRC tumor growth and metastasis in More >

Nan Zhu¹, Mahui Si¹, Ning Yang, Yingying Jing, Yong Fu, Xijun Zhao, Zhipeng Lin, Guangshun Yang

Oncology Research, Vol.25, No.6, pp. 1001-1008, 2017, DOI:10.3727/096504016X14796039599926

Abstract Ras-association domain family 6 (RASSF6), a member of the RASSF family, is frequently downregulated in various types of cancer. However, the roles of RASSF6 in human hepatocellular carcinoma (HCC) are still unclear. In this study, we investigated the biological functions and related molecular mechanisms in HCC. Our results found that RASSF6 is expressed in low amounts in HCC tissues and cell lines. Overexpression of RASSF6 obviously inhibited the proliferation, invasion, and EMT process in HCC cells. Furthermore, overexpression of RASFF6 greatly downregulated the protein levels of phosphorylated focal adhesion kinase (FAK), MMP-2, and MMP-9 in More >

XINFENG ZHANG^1,2,#, SHUANG LI^2,#, MEIRU SONG^1,2, YUE CHEN³, LIANGZHENG CHANG³, ZHERUI LIU⁴, HONGYUAN DAI³, YUTAO WANG⁴, GANGQI YANG³, YUN JIANG^5,6,*, YINYING LU^1,2,*

Oncology Research, Vol.32, No.4, pp. 679-690, 2024, DOI:10.32604/or.2024.046231

Abstract Liver cancer is a prevalent malignant cancer, ranking third in terms of mortality rate. Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer. Hepatocellular carcinoma (HCC) has low expression of focal adhesion kinase (FAK), which increases the risk of metastasis and recurrence. Nevertheless, the efficacy of FAK phosphorylation inhibitors is currently limited. Thus, investigating the mechanisms by which FAK affects HCC metastasis to develop targeted therapies for FAK may present a novel strategy to inhibit HCC metastasis. This study examined the correlation between FAK expression and the prognosis of HCC. Additionally,… More >

QIAN HU, MENGYAO WANG, JINJIN WANG, YALI TAO, TING NIU^*

Oncology Research, Vol.32, No.4, pp. 753-768, 2024, DOI:10.32604/or.2023.043647

Abstract Multiple myeloma (MM) is a hematologic malignancy notorious for its high relapse rate and development of drug resistance, in which cell adhesion-mediated drug resistance plays a critical role. This study integrated four RNA sequencing datasets (CoMMpass, GSE136337, GSE9782, and GSE2658) and focused on analyzing 1706 adhesion-related genes. Rigorous univariate Cox regression analysis identified 18 key prognosis-related genes, including KIF14, TROAP, FLNA, MSN, LGALS1, PECAM1, and ALCAM, which demonstrated the strongest associations with poor overall survival (OS) in MM patients. To comprehensively evaluate the impact of cell adhesion on MM prognosis, an adhesion-related risk score (ARRS)… More >

Demiao Chu¹, Redžo Hasanagić², Leila Fathi³, Mohsen Bahmani^3,*, Miha Humar⁴

Journal of Renewable Materials, Vol.11, No.12, pp. 4061-4078, 2023, DOI:10.32604/jrm.2023.043657

Abstract This study aimed to investigate the water absorption capacity of thermally modified and non-modified spruce and blue-stained spruce wood. The wettability of wood depends on various factors, including its type, density, porosity, and surface treatment. Wood can swell and become distorted when exposed to water or humidity, impacting its structural integrity. Hence, it is crucial to consider the water and water vapour uptake in the wood when choosing materials for applications that are likely to be exposed to moisture. Various moisture absorption tests were conducted to assess water absorption capacity, including short-term and long-term water… More > Graphic Abstract

Zhaohe Dai^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.2, pp. 1-1, 2023, DOI:10.32604/icces.2023.09223

Abstract The flexible and clinging nature of ultra-thin films require the understanding of their elastic and adhesive properties in a wide range of circumstances from fabrications to applications. Simultaneously measuring both properties, however, is extremely difficult as the film thickness diminishes to nanoscales. In this talk, I will show our recent work that addresses such difficulties through peeling by vertically pulling thin films off from the substrates (we thus refer to it as “pull-to-peel”). Particularly, we perform in-situ pull-to-peel of graphene and MoS2 films in a scanning electron microscope and achieve simultaneous determination of their Young’s More >

D. Boinon, C. Charles, L. Fasse, J. Journiac, G. Pallubicki, E. Guerdoux-Ninot, G. Ninot, A. Couillet, J.-B. Le Provost, J. Savard, S. Dauchy

Psycho-Oncologie, Vol.16, No.1, pp. 173-181, 2022, DOI:10.3166/pson-2022-0179

Abstract La thérapie cognitivocomportementale de l’insomnie (TCC-I) demeure difficile d’accès pour les patients atteints de cancer. Sa digitalisation semble une solution prometteuse pour bénéficier au plus grand nombre. La faisabilité d’un programme TCC-I québécois a été démontrée en France, tout en révélant les limites d’un dispositif suivi en autonomie et à distance. L’enjeu reste de mieux comprendre le rôle des professionnels de santé dans l’accompagnement des patients dans ce type de programme. C’est l’objectif de l’étude Sleep-4-All-2.0 dont nous présenterons ici le protocole. More >

E. Guerdoux, L. Coutant, M. Del Rio, S. Gourgou, F. Quenet, G. Ninot

Psycho-Oncologie, Vol.16, No.1, pp. 192-198, 2022, DOI:10.3166/pson-2022-0177

Abstract Objectif : Évaluer l’implémentation d’une pratique quotidienne de cohérence cardiaque chez des patients opérés pour une carcinose péritonéale.
Matériel et méthode : Étude pilote monocentrique, ouverte, contrôlée, randomisée non comparative, incluant 20 patients en soins courants vs 40 patients formés à la cohérence cardiaque avec biofeedback et guide respiratoire pour une pratique au domicile enregistrée.
Résultats attendus : Adhésion satisfaisante au programme, pouvant caractériser les éléments favorisant son implémentation avant et après chirurgie et évaluation de son impact sur l’anxiété.
Perspectives : Efficacité à déterminer pour transférer ce soin de support. More >

Yu Fan, Jianhua Guo, Xihui Hu, Rui Wang^*, Weiqiang Xu

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.9, pp. 2431-2447, 2023, DOI:10.32604/fdmp.2023.027604

Abstract Drilling technologies based on oil-based drilling fluids and strong inhibitory saltwater fluids are affected by drawbacks such as downhole accidents where sticking and wellbore instabilities occur. Existing polyamine drilling fluids also exhibit problems such as easy decomposition and poor inhibition performances. In order to mitigate these issues, additives can be used, such as polyamine inhibitors and the synthesis of nanometer filtrate reducers. Tests conducted in the frame of this study with a polyamine drilling fluid and such additives show that this fluid has the same inhibitory, plugging, lubricating, and wellbore-stability performances as oil-based drilling fluids. More > Graphic Abstract

L. Amaadour, I. Lahrch, O. Siyouri, K. Oualla, Z. Benbrahim, S. Arifi, C. Aarab, S. El Fakir, N. Mellas

Psycho-Oncologie, Vol.17, No.1, pp. 38-43, 2023, DOI:10.3166/pson-2022-0221

Abstract Introduction: La Covid-19 constitue une cause de plusieurs affections mentales, notamment chez les patients atteints de cancer qui sont déjà considérés comme une population vulnérable. Ainsi, l’objectif de la présente étude était d’évaluer les troubles psychologiques des patients suivis pour une maladie tumorale maligne, sous traitement médical systémique, ayant eu une infection au SARS-CoV2 ; ainsi que les conséquences que ces troubles psychologiques peuvent avoir sur l’adhésion aux soins oncologiques.
Méthode: Il s’agit d’une étude transversale sur une période de quatre mois (pic de la pandémie) menée au département d’oncologie médicale du centre hospitalier universitaire Hassan-II de… More >