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    ARTICLE

    Comparison of creatinine and cystatin C for estimation of glomerular filtration rate in pediatric patients after Fontan operation

    Danielle Kirelik1,2, Mark Fisher2, Michael DiMaria2, Danielle E. Soranno3, Katja M. Gist2

    Congenital Heart Disease, Vol.14, No.5, pp. 760-764, 2019, DOI:10.1111/chd.12776

    Abstract Background: There are several limitations when using creatinine to estimate glomerular filtration rate, especially in children with chronic medical conditions who are at high risk of kidney dysfunction. Cystatin C has been the recent focus of research as a replacement biomarker for creatinine. Our objective was to compare the 2 biomarkers in pediatric single‐ventricle heart disease patients who have undergone the Fontan operation. We hypothesized that there would be poor correlation and agreement between the 2 estimates of renal function.
    Methods: This was a single center retrospective chart review of 20 patients who had previously undergone Fontan… More >

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