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    ARTICLE

    Delayed puberty and abnormal anthropometry and its associations with quality of life in young Fontan survivors: A multicenter cross-sectional study

    Shaji C. Menon1, Ragheed Al-Dulaimi1, Brian W. McCrindle2, David J. Goldberg3, Ritu Sachdeva4, Bryan H. Goldstein5, Thomas Seery6, Karen C. Uzark7, Anjali Chelliah8, Ryan Butts9, Heather Henderson10, Tiffanie Johnson11, Richard V. Williams1

    Congenital Heart Disease, Vol.13, No.3, pp. 463-469, 2018, DOI:10.1111/chd.12597

    Abstract Introduction: We sought to evaluate the prevalence of delayed puberty and abnormal anthropometry and its association with quality of life (QoL) in young Fontan survivors.
    Methods: This was a cross-sectional study at 11 Pediatric Heart Network centers. Demographic and clinical data, anthropomety, and Tanner stage were collected. Anthropometric measurements and pubertal stage were compared to US norms. QoL was assessed using Pediatric Quality of Life inventory (PedsQL). Mixed effects regression modeling adjusting for clustering by center was used to evaluate factors associated with abnormal anthropometry and delayed puberty and associations with QoL.
    Results: Of the 299 subjects, 42%… More >

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