Zhongwei Wang, Yali Wang, Hongtao Ren, Yingying Jin, Ya Guo
Oncology Research, Vol.25, No.4, pp. 571-577, 2017, DOI:10.3727/97818823455816X14760478220149
Abstract Zinc and ring finger 3 (ZNRF3), which belongs to the E3 ubiquitin ligase family, is involved in the progression
and development of cancer. However, the expression and function of ZNRF3 in human nasopharyngeal carcinoma (NPC) remain unclear. Thus, the aim of this study was to investigate the role of ZNRF3 in human NPC.
Our results showed that ZNRF3 was downregulated in NPC cell lines. Restoration of ZNRF3 significantly
inhibited the proliferation of NPC cells and tumor xenograft growth in vivo. In addition, overexpression of
ZNRF3 suppressed migration and invasion, as well as attenuated the epithelial–mesenchymal More >
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