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Search Results (28)
  • Open Access

    ARTICLE

    Long non-coding RNA-ATB induces trastuzumab resistance and aggravates the progression of gastric cancer by repressing miR- 200c via ZNF217 elevation

    JIAZHUANG LI*, WEI ZHANG, SHOUBAO GAO, LI SUN, QINGYANG TAI, YING LIU

    BIOCELL, Vol.47, No.10, pp. 2313-2320, 2023, DOI:10.32604/biocell.2023.029860

    Abstract Background: Trastuzumab resistance accounts for chemotherapy failure in gastric cancer patients in clinical practice. The significance of long non-coding RNAs (lncRNAs) in the maintenance of drug resistance in gastric cancer has been already underlined. Method: This study aimed to identify the specific role of lncRNA-ATB in gastric cancer progression and trastuzumab resistance. The downstream miRs of lncRNA-ATB and target genes of miRs were predicted by bioinformatics analysis and verified using dual luciferase reporter assay. Loss- and gain-function assays were performed to explore the roles of lncRNA-ATB, miR-200c, and zinc-finger protein 217 (ZNF217) in the cell functions and trastuzumab resistance of… More >

  • Open Access

    ARTICLE

    Zinc alpha 2 glycoprotein (ZAG): A potential novel pharmacological target in diabetic retinopathy

    UMAPATHY PRAKASH1, SUBRAMANIAM RAJESH BHARATHIDEVI1,*, RAMYA R. NADIG2, RAJIV RAMAN2, GIRISH SHIV RAO2, MUNA BHENDE2

    BIOCELL, Vol.47, No.7, pp. 1473-1482, 2023, DOI:10.32604/biocell.2023.027804

    Abstract Zinc alpha 2 glycoprotein (ZAG) is a 41 KDa secretory soluble glycoprotein found in different body fluids like the serum, saliva, sweat, breast milk, and urine. It is also found in tissues like the testis, epididymis, kidney, spleen, liver, lungs, heart, and brain. ZAG is an adipokine with multiple roles, including lipid mobilization, modulating glucose metabolisms, improving insulin sensitivity, inhibiting tumor proliferation through RNAse activity, and suppressing inflammation. Low levels of zinc and ZAG are linked to metabolic syndrome and are also reported as potential biomarkers for diabetic nephropathy. Interestingly zinc has been found to regulate the binding of ZAG… More >

  • Open Access

    ARTICLE

    The zinc figure protein ZNF575 impairs colorectal cancer growth via promoting p53 transcription

    NING AN1,#, HEQING PENG2,#, MIN HOU3, DUOFENG SU2, LIU WANG4, XIAOGANG SHEN5,*, MING ZHANG1,*

    Oncology Research, Vol.31, No.3, pp. 307-316, 2023, DOI:10.32604/or.2023.028564

    Abstract Zinc-finger proteins play different roles in cancer; however, the function of zinc-finger protein ZNF575 in cancer remains unclear. In the present study, we aimed to determine the function and expression of ZNF575 in colorectal cancer. Proliferation assay, colony formation assay, and tumor model in mice were used to investigate the function of ZNF575 after ectopic expression of ZNF575 in colorectal cancer (CRC) cells. RNA sequencing, ChIP, and luciferase assays were used to investigate the mechanism behind ZNF575 regulation of CRC cell growth. The expression of ZNF575 was determined by IHC staining in 150 pairs of malignant CRC tissues, followed by… More > Graphic Abstract

    The zinc figure protein ZNF575 impairs colorectal cancer growth via promoting p53 transcription

  • Open Access

    ARTICLE

    Response of Contrasting Rice Genotypes to Zinc Sources under Saline Conditions

    Muhammad Jan1,*, Muhammad Anwar-Ul-Haq2, Talha Javed3, Sadam Hussain4,*, Ilyas Ahmad5, Muhammad Ashraf Sumrah6, Javed Iqbal7, Babar Hussain Babar8, Aqsa Hafeez9, Muhammad Aslam5, Muhammad Tahir Akbar10, Marjan Aziz6, Khadiga Alharbi11, Izhar Ullah12

    Phyton-International Journal of Experimental Botany, Vol.92, No.5, pp. 1361-1375, 2023, DOI:10.32604/phyton.2023.026620

    Abstract Abiotic stresses are among the major limiting factors for plant growth and crop productivity. Among these, salinity is one of the major risk factors for plant growth and development in arid to semi-arid regions. Cultivation of salt tolerant crop genotypes is one of the imperative approaches to meet the food demand for increasing population. The current experiment was carried out to access the performance of different rice genotypes under salinity stress and Zinc (Zn) sources. Four rice genotypes were grown in a pot experiment and were exposed to salinity stress (7 dS m−1), and Zn (15 mg kg−1 soil) was… More >

  • Open Access

    ARTICLE

    Expression and function of long non-coding RNA DLX6-AS1 in endometrial cancer

    WEI SHI1,2,3,#, JIANXIA LIN1,2,3,#, RONG JIN1,2,3, XIANJING XIE1,2,3, YAN LIANG1,2,3,*

    BIOCELL, Vol.47, No.4, pp. 869-877, 2023, DOI:10.32604/biocell.2023.026037

    Abstract Background: LncRNA DLX6-AS1 has been uncovered to exert effects on various cancers. Nevertheless, the impacts of DLX6-AS1 on endometrial cancer (EC) development remained obscure. The study explored the influence of DLX6-AS1 on EC progression via the microRNA (miR)-374a-3p/zinc-finger protein (ZFX) axis.Methods: EC cell lines were collected and DLX6-AS1, miR-374a-3p, and ZFX levels in EC cell lines were detected. The EC cells were transfected with DLX6-AS1, miR-374a-3p, and ZFX constructs to examine the biological functions of EC cells. The xenograft model was established for detecting tumor growth. Rescue experiments were conducted to verify the interaction of DLX6-AS1, miR-374a-3p, and ZFX in… More > Graphic Abstract

    Expression and function of long non-coding RNA DLX6-AS1 in endometrial cancer

  • Open Access

    ARTICLE

    Facile Preparation of Dopamine-Modified Magnetic Zinc Ferrite Immobilized Lipase for Highly Efficient Synthesis of OPO Functional Lipid

    Xue Huang1,*, Zeyu Chen1, Ruizhao Yang1, Guangzhu Feng2

    Journal of Renewable Materials, Vol.11, No.5, pp. 2301-2319, 2023, DOI:10.32604/jrm.2023.025888

    Abstract 1,3-Dioleoyl-2-palmitoylglycerol (OPO) has been a hotspot of functional oils research in recent years, but due to the high cost of sn-1,3 specific lipase in enzymatic synthesis and the lack of biocatalyst stability, large-scale industrial application is difficult. In this study, the prepared magnetic ZnFe2O4 was functionalized with dopamine to obtain ZnFe2O4@PDA, and the nano-biocatalyst ZnFe2O4@PDA@RML was prepared by immobilizing sn-1,3 specific lipase of Rhizomucor miehei lipase (RML) via a cross-linking method. The existence of RML on ZnFe2O4@PDA was confirmed by XRD, FTIR, SEM, and TEM. This strategy proved to be simple and effective because the lipase immobilized on magnetic nanoparticles… More > Graphic Abstract

    Facile Preparation of Dopamine-Modified Magnetic Zinc Ferrite Immobilized Lipase for Highly Efficient Synthesis of OPO Functional Lipid

  • Open Access

    ARTICLE

    Application of Zinc, Iron and Boron Enhances Productivity and Grain Biofortification of Mungbean

    Muhammad Zafar1, Siraj Ahmed1, Muhammad Kashif Munir1, Nawal Zafar1, Muhammad Saqib1, Muhammad Aleem Sarwar2, Saba Iqbal1, Baber Ali3, Naveed Akhtar1, Basharat Ali4,*, Sadam Hussain5,*, Muhammad Saeed6, Mohammad Khalid Al-Sadoon7, Aneela Gulnaz8

    Phyton-International Journal of Experimental Botany, Vol.92, No.4, pp. 983-999, 2023, DOI:10.32604/phyton.2023.025813

    Abstract Deficiencies of essential vitamins, iron (Fe), and zinc (Zn) affect over one-half of the world’s population. A significant progress has been made to control micronutrient deficiencies through supplementation, but new approaches are needed, especially to reach the rural poor. Agronomic biofortification of pulses with Zn, Fe, and boron (B) offers a pragmatic solution to combat hidden hunger instead of food fortification and supplementation. Moreover, it also has positive effects on crop production as well. Therefore, we conducted three separate field experiments for two consecutive years to evaluate the impact of soil and foliar application of the aforementioned nutrients on the… More >

  • Open Access

    ARTICLE

    Molecular Dynamics Simulation of Interface Properties between Water-Based Inorganic Zinc Silicate Coating Modified by Organosilicone and Iron Substrate

    Hengjiao Gao1, Yuqing Xiong1,*, Kaifeng Zhang1, Shengzhu Cao1, Mingtai Hu1, Yi Li1, Ping Zhang2, Xiaoli Liu3

    Journal of Renewable Materials, Vol.11, No.4, pp. 1715-1729, 2023, DOI:10.32604/jrm.2022.024023

    Abstract The interface properties of Fe(101)/zinc silicate modified by organo-siloxane (KH-570) was studied by using the method of molecular dynamics simulation. By calculating the temperature and energy fluctuation of equilibrium state, equilibrium concentration distribution, MSD of layer and different groups, and interaction energy of two interface models, the influencing mechanism on the interface properties of adding organosiloxane into coating system was studied at the atomic scale. It shows that the temperature and energy of interface oscillated in a small range and it was exited in a state of dynamic equilibrium within the initial simulation stage (t < 20 ps). It can… More > Graphic Abstract

    Molecular Dynamics Simulation of Interface Properties between Water-Based Inorganic Zinc Silicate Coating Modified by Organosilicone and Iron Substrate

  • Open Access

    REVIEW

    Gut microbiome modulation: Ancillary effects of inorganic nanoparticles on gut microflora

    SEHRISH ABBAS1, BUSHRA UZAIR1,*, MAISRA AZHAR BUTT1, FARID MENAA2, BARKAT A. KHAN3,*

    BIOCELL, Vol.47, No.2, pp. 245-260, 2023, DOI:10.32604/biocell.2023.025311

    Abstract The association of gut microflora and human health is being increasingly recognized, and the impact of gut microflora on the host is well characterized, including the body’s energy metabolism and immune system maintenance. Several human diseases, including metabolic, autoimmune, obesity, hypothyroidism, and intestinal disorders, are closely associated with gut dysbiosis. Inorganic nanoparticles (NPs) are extensively utilized in numerous fields due to their distinctive, attractive physicochemical properties. Estimation of the potential impacts of NPs, with a high number of microorganisms inside the human body (microbiota) and its genomes (microbiome), represents one of the most important aspects of nano-toxicology. This review article… More > Graphic Abstract

    Gut microbiome modulation: Ancillary effects of inorganic nanoparticles on gut microflora

  • Open Access

    ARTICLE

    Chickpea C2H2-Type Zinc Finger Protein ZF2 is a Positive Regulator in Drought Response in Arabidopsis

    Sushuang Liu1,2,#, Yanmin Liu1,2,#, Chundong Liu1, Xingwang Yu2,3, Hao Ma2,4,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.2, pp. 577-590, 2023, DOI:10.32604/phyton.2022.023738

    Abstract Drought is a major abiotic stress limiting agricultural crops production worldwide. In our study, we isolated a novel C2H2-type zinc finger protein gene ZF2 from chickpea. ZF2 consisted of 232 amino acids with two QALGGH motifs in Cys2/His2 zinc finger domain. Transient expression analysis of ZF2:GFP fusion protein showed that ZF2 was a nuclear localized protein. In the yeast assay system, the full-length of ZF2 did not show transcriptional activation. Expression of ZF2 gene was enhanced by treatments of several abiotic stresses and phytohormones. The promoter region of ZF2 contained multiple stress- and hormone-related cis-elements. Overexpression of ZF2 in Arabidopsis… More >

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