FEI LIU1, JIAZHANG WEI2, JIAO LAN1, YONGLI WANG2, JIANXIANG YE3, CHENG Su1, MINGZHENG MO1, FENGZHU TANG2, BING LI2, MIN LI2, WEIMING DENG2, LINSONG YE2, Wenlin HUANG2, JINGJIN WENG2, WEI JIAO1,*, SHENHONG QU2,*
BIOCELL, Vol.46, No.12, pp. 2659-2669, 2022, DOI:10.32604/biocell.2022.022886
- 10 August 2022
Abstract Our previous studies suggested a potential interaction between the POK erythroid myeloid ontogenic factor ZBTB7A and glucose transporter 1 (GLUT1) in nasopharyngeal carcinoma (NPC). This study was designed to confirm the interaction and further evaluate the precise mechanism by which ZBTB7A and GLUT1 regulate NPC development. The binding sites between ZBTB7A and the promoter of GLUT1 were predicted by bioinformatics. Gene expression was measured by quantitative real-time polymerase chain reaction (qPCR), western blotting, and immunohistochemistry. The activities of key glycolysis enzymes, including hexokinase (HK), pyruvate kinase (PK), lactate dehydrogenase (LDH), and lactate, were detected using… More >
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