FEI SHA¹, DAISHAN XIN², JUN XU³, ZHIWEI ZHENG¹, WENXIN LIN¹, XIAORUI CAI¹, FEI LIN³, MINGHAO ZHENG^1,*, JIAOLING CHEN^1,*

BIOCELL, Vol.48, No.3, pp. 443-451, 2024, DOI:10.32604/biocell.2023.029188

Abstract Background: Curcumin is a plant polyphenol with antitumor properties and inhibits the development of colorectal cancer (CRC). However, as the molecular mechanism associated is still unclear, our study aimed to explore the underlying molecular mechanisms by which curcumin inhibits CRC. Methods: HT29 and SW480 cells were treated with curcumin or/and Doxycycline (DOX), and cell viability, colony forming ability, migration and invasion were confirmed by cell counting kit-8 (CCK-8), colony forming, Transwell assays. And Yes-associated protein 1 (YAP) and PDZ-binding motif (TAZ) signaling-related genes or proteins were analyzed using reverse transcription quantitative real-time PCR (RT-qPCR), western blot, and immunofluorescence assays. Then… More > Graphic Abstract

LIJUN JIANG¹, WENMIN JI¹, YAJIE GONG², JIAJUN LI², JINCHUN LIU^1,*

BIOCELL, Vol.47, No.8, pp. 1803-1810, 2023, DOI:10.32604/biocell.2023.029516

Abstract Background: Colorectal cancer (CRC) is one of the most common malignancies. Early diagnosis is the key to effective treatment of CRC. Since microRNAs (miRNAs) can be used as biomarkers of CRC, the objective of this work was to examine the effect of miR-520f-3p, which targets YAP1 (Yes-associated protein 1), on the ability of CRC cells to proliferate, invade, migrate, and undergo epithelial-mesenchymal transition (EMT). Methods: A miR-520f-3p mimic was used to overexpress miR-520f-3p in HT29 cells. To establish the tumor-bearing mouse model, transfected HT29 cells were subcutaneously implanted into BALB/c-nu nude mice, and YAP1 and miR-520f-3p levels were determined using… More > Graphic Abstract

Babu H. Soumya^1,*, N. Vijayakumar², K. Gopakumar³

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 1197-1207, 2023, DOI:10.32604/iasc.2023.031575

Abstract The Henon map forms one of the most-studied two-dimensional discrete-time dynamical systems that exhibits chaotic behavior. The Henon map takes a point in the plane and maps it to a new point . In this paper, a chaotic pulse generator based on the chaotic Henon map is proposed. It consists of a Henon map function subcircuit to realize the Henon map and another subcircuit to perform the iterative operation. The Henon map subcircuit comprises operational amplifiers, multipliers, delay elements and resistors, whereas, the iterative subcircuit is implemented with a simple design that comprises of an edge forming circuit followed by… More >

USAMA SHARIF AHMAD, KARTHIK SARAVANAN, HONG WAN^*

Oncology Research, Vol.29, No.6, pp. 377-391, 2021, DOI:10.32604/or.2022.026085

Abstract The Yes-associated protein (YAP) is a downstream effector of the Hippo pathway and acts as a key transcription co-factor to regulate cell migration, proliferation, and survival. The Hippo pathway is evolutionarily conserved and controls tissue growth and organ size. Dysregulation and heterogeneity of this pathway are found in cancers, including oral squamous cell carcinoma (OSCC), leading to overexpression of YAP and its regulated proliferation machinery. The activity of YAP is associated with its nuclear expression and is negatively regulated by the Hippo kinase-mediated phosphorylation resulting in an induction of its cytoplasmic translocation. This review focuses on the role of YAP… More >

Suha Q. AL-Shahrabalee^*, Hussein Alaa Jaber

Journal of Renewable Materials, Vol.11, No.3, pp. 1485-1498, 2023, DOI:10.32604/jrm.2023.025011

Abstract Cancerous diseases and diseases resulting from bacteria and fungi are some of the pressures that humans face. Therefore, the development of biomaterials that are resistant to cancerous diseases, bacteria, and fungi has become one of the requirements of the medical field to extend the life of the biomaterial and fight pathogens after implanting these materials inside the human body. One of the important biomaterials used in the field of orthopedics is hydroxyapatite. In this research, Nano substituted hydroxyapatite was prepared by the wet precipitation method, including replacing 5% of the calcium ions with neodymium, cerium, magnesium, and zinc ions in… More > Graphic Abstract

Ahmed M. Elmogy^1,2,*, Wael M. Elawady²

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 385-400, 2023, DOI:10.32604/iasc.2023.032349

Abstract One of the great concerns when tackling nonlinear systems is how to design a robust controller that is able to deal with uncertainty. Many researchers have been working on developing such type of controllers. One of the most efficient techniques employed to develop such controllers is sliding mode control (SMC). However, the low order SMC suffers from chattering problem which harm the actuators of the control system and thus unsuitable to be used in many practical applications. In this paper, the drawbacks of low order traditional sliding mode control (FOTSMC) are resolved by presenting a novel adaptive radial basis function… More >

QING YIN¹, CAIHONG LIU¹, WENYING JIANG¹, HAIHUI GONG¹, CHUNYUN LI^1,2,3,*, ZUPING HE^1,2,3,*

BIOCELL, Vol.47, No.1, pp. 33-39, 2023, DOI:10.32604/biocell.2023.023567

Abstract Yes-associated protein 1 (YAP1) is a downstream effector of the Hippo signaling pathway, and it is involved in tumorigenesis, tissue repair, growth, and development. In this review, the biological roles and the mechanisms of YAP1 in mediating stem cell fate decisions are discussed, including cell proliferation, differentiation, and apoptosis. In general, YAP1 promotes the proliferation and differentiation of stem cells, including embryonic stem cells and adult stem cells. It inhibits apoptosis by binding to the transcription factors, e.g., transcriptional enhanced associate domain (TEAD), Smad, runt-related transcription factor 1/2, p73, p63, and Erb84, to maintain tissue homeostasis. The translocalization of YAP1… More >

DAWEI ZHU^1,#, LEI ZHANG^1,#, XIAOKAI SHI¹, SHENGLIN GAO¹, CHUANG YUE¹, LIFENG ZHANG¹, YU BAI¹, QIFENG WANG², ATSUSHI OKADA³, TAKAHIRO YASUI³, CHAO WANG^1,4, XINGANG CUI^4,5,*, LI ZUO^1,*

Oncology Research, Vol.29, No.3, pp. 159-174, 2021, DOI:10.32604/or.2022.03458

Abstract Identifying prognostic indicators of clear cell renal cell carcinoma (ccRCC) and elucidating the mechanisms underlying ccRCC progression are crucial for improving ccRCC patient prognosis. This study investigated the clinical significance and biological role of Ring finger protein 43 (RNF43) in ccRCC. Two independent cohorts of patients with ccRCC were employed to determine the prognostic significance of RNF43 by immunohistochemistry and statistical analyses. In vitro and in vivo experiments, RNA-seq, and other techniques were used to determine the biological role of RNF43 in ccRCC and related molecular mechanisms. RNF43 expression was commonly decreased in ccRCC specimens, and low expression of RNF43… More >

Nora Elizondo-Villarreal^1,*, Luz H. Verástegui-Dominguez¹, Jose J. Quijano-Briones¹, Francisco J. Vázquez-Rodríguez², Eden Rodríguez-Castellanos³, Enrique López-Cuellar³, Ernesto Torres-Lopez¹, Victor M. Castaño-Meneses^4,*

Journal of Renewable Materials, Vol.10, No.12, pp. 3559-3572, 2022, DOI:10.32604/jrm.2022.021945

Abstract

Agave salmiana ash and poultry eggshell powder as CaO sources were used for obtaining nanostructured hydroxyapatite (HAP). The synthesis was carried out by the Green Chemistry Hydrothermal Biosynthesis at 180°C with a pH of 5, by reacting CaO from Agave Salmiana ash and Eggshell powder, with dibasic calcium phosphate (CaHPO₄•2H₂O) in an aqueous solution, with Aloe barbadensis extract. The product was characterized by X-ray diffraction, Fourier-transform infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM). The size and shape of the hydroxyapatite particles changed dramatically in the presence of Aloe barbadensis. Large crystals of Hydroxyapatite were observed… More > Graphic Abstract

Ming Jia^*1, Yulin Xiong^†1, Maoshi Li^*, Qing Mao^*

Oncology Research, Vol.28, No.4, pp. 371-383, 2020, DOI:10.3727/096504020X15853075736554

Abstract Chemotherapy is critical for the treatment of hepatocellular carcinoma (HCC). Despite the proapoptotic effects of corosolic acid (CA) treatment, its underlying mechanism is not completely clear. The aim of this study was to determine the molecular mechanism of CA in HCC treatment. MTT assay was used to determine the IC50 of CA. Immunoprecipitation and immunofluorescence were used to detect the interaction and subcellular localization of Yes-associated protein (YAP) and mouse double minute 2 (MDM2). In addition, in vivo xenotransplantation was performed to assess the effects of CA, YAP, and MDM2 on tumorigenesis. The IC50 of CA was about 40 µM… More >