Haowen Liang¹, Jiaming Bai^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012563

Abstract Defects are pivotal in influencing the mechanical performance of the hydroxyapatite (HAp) porous structure. In vat photopolymerization (VP) fabrication, directly peeling HAp/polymer green structure from the platform is an efficient approach but often introduces defects, compromising the mechanical performance of sintered HAp scaffolds. The peeling process is a physical phenomenon where the photocured HAp/polymer green structure exhibits resistance against applied peeling forces, which is influenced by its modulus and toughness. In this study, the peeling behavior of cubic-pore HAp (CP-HAp) green structures with varying levels of modulus and toughness was investigated in detail. The characterization… More >

KAITIAN ZHANG^1,#, MINGZHU LI^2,#,*, JIANPING ZHANG³, JINFENG LI², KUNLANG LI², HUANQIAN LU², JINYAN LV²

BIOCELL, Vol.48, No.10, pp. 1489-1501, 2024, DOI:10.32604/biocell.2024.053930 - 02 October 2024

Abstract Objective: Studies have demonstrated that administering statins promptly following myocardial ischemia/reperfusion (MI/R) can confer cardioprotective benefits. This study investigates whether Lovastatin can modulate the Yes-associated protein/Transcriptional co-activator with PDZ-binding motif (YAP/TAZ) signaling pathway to mitigate cardiomyocyte injury caused by hypoxia/reoxygenation (H/R). Methods: The in vitro MI/R model was established by H/R in rat myocardial H9c2 cells, and the cells were pretreated with varying doses of Lovastatin before reoxygenation. The extent of cellular injury was evaluated by measuring the myocardial enzyme content and cell viability. The levels of oxidative stress and inflammatory factors were quantified by enzyme-linked… More > Graphic Abstract

Deni Fajar Fitriyana^1,2,*, Rifky Ismail^1,3,*, Athanasius Priharyoto Bayuseno¹, Januar Parlaungan Siregar^4,5, Tezara Cionita⁶

Journal of Renewable Materials, Vol.12, No.6, pp. 1145-1163, 2024, DOI:10.32604/jrm.2024.052165 - 02 August 2024

Abstract Hydroxyapatite (HA) is a bio ceramic commonly utilized in bone tissue engineering due to its bioactive and osteoconductive properties. Crab shells are usually disregarded as waste material despite their significant CaCO content, and have not been widely utilized in the synthesis of HA. This study aims to synthesize and analyze HA derived from crab shells using the hydrothermal method with different durations of holding time. This study utilized precipitated calcium carbonate (PCC) derived from crab shells. With a hydrothermal reactor set at 160°C and varying holding times of 14 (HA_14), 16 (HA_16), and 18 (HA_18)… More > Graphic Abstract

FEI SHA¹, DAISHAN XIN², JUN XU³, ZHIWEI ZHENG¹, WENXIN LIN¹, XIAORUI CAI¹, FEI LIN³, MINGHAO ZHENG^1,*, JIAOLING CHEN^1,*

BIOCELL, Vol.48, No.3, pp. 443-451, 2024, DOI:10.32604/biocell.2023.029188 - 15 March 2024

Abstract Background: Curcumin is a plant polyphenol with antitumor properties and inhibits the development of colorectal cancer (CRC). However, as the molecular mechanism associated is still unclear, our study aimed to explore the underlying molecular mechanisms by which curcumin inhibits CRC. Methods: HT29 and SW480 cells were treated with curcumin or/and Doxycycline (DOX), and cell viability, colony forming ability, migration and invasion were confirmed by cell counting kit-8 (CCK-8), colony forming, Transwell assays. And Yes-associated protein 1 (YAP) and PDZ-binding motif (TAZ) signaling-related genes or proteins were analyzed using reverse transcription quantitative real-time PCR (RT-qPCR), western More > Graphic Abstract

LIJUN JIANG¹, WENMIN JI¹, YAJIE GONG², JIAJUN LI², JINCHUN LIU^1,*

BIOCELL, Vol.47, No.8, pp. 1803-1810, 2023, DOI:10.32604/biocell.2023.029516 - 28 August 2023

Abstract Background: Colorectal cancer (CRC) is one of the most common malignancies. Early diagnosis is the key to effective treatment of CRC. Since microRNAs (miRNAs) can be used as biomarkers of CRC, the objective of this work was to examine the effect of miR-520f-3p, which targets YAP1 (Yes-associated protein 1), on the ability of CRC cells to proliferate, invade, migrate, and undergo epithelial-mesenchymal transition (EMT). Methods: A miR-520f-3p mimic was used to overexpress miR-520f-3p in HT29 cells. To establish the tumor-bearing mouse model, transfected HT29 cells were subcutaneously implanted into BALB/c-nu nude mice, and YAP1 and miR-520f-3p… More > Graphic Abstract

Babu H. Soumya^1,*, N. Vijayakumar², K. Gopakumar³

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 1197-1207, 2023, DOI:10.32604/iasc.2023.031575 - 29 April 2023

Abstract The Henon map forms one of the most-studied two-dimensional discrete-time dynamical systems that exhibits chaotic behavior. The Henon map takes a point in the plane and maps it to a new point . In this paper, a chaotic pulse generator based on the chaotic Henon map is proposed. It consists of a Henon map function subcircuit to realize the Henon map and another subcircuit to perform the iterative operation. The Henon map subcircuit comprises operational amplifiers, multipliers, delay elements and resistors, whereas, the iterative subcircuit is implemented with a simple design that comprises of an More >

Suha Q. AL-Shahrabalee^*, Hussein Alaa Jaber

Journal of Renewable Materials, Vol.11, No.3, pp. 1485-1498, 2023, DOI:10.32604/jrm.2023.025011 - 31 October 2022

Abstract Cancerous diseases and diseases resulting from bacteria and fungi are some of the pressures that humans face. Therefore, the development of biomaterials that are resistant to cancerous diseases, bacteria, and fungi has become one of the requirements of the medical field to extend the life of the biomaterial and fight pathogens after implanting these materials inside the human body. One of the important biomaterials used in the field of orthopedics is hydroxyapatite. In this research, Nano substituted hydroxyapatite was prepared by the wet precipitation method, including replacing 5% of the calcium ions with neodymium, cerium, More > Graphic Abstract

Ahmed M. Elmogy^1,2,*, Wael M. Elawady²

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 385-400, 2023, DOI:10.32604/iasc.2023.032349 - 29 September 2022

Abstract One of the great concerns when tackling nonlinear systems is how to design a robust controller that is able to deal with uncertainty. Many researchers have been working on developing such type of controllers. One of the most efficient techniques employed to develop such controllers is sliding mode control (SMC). However, the low order SMC suffers from chattering problem which harm the actuators of the control system and thus unsuitable to be used in many practical applications. In this paper, the drawbacks of low order traditional sliding mode control (FOTSMC) are resolved by presenting a… More >

QING YIN¹, CAIHONG LIU¹, WENYING JIANG¹, HAIHUI GONG¹, CHUNYUN LI^1,2,3,*, ZUPING HE^1,2,3,*

BIOCELL, Vol.47, No.1, pp. 33-39, 2023, DOI:10.32604/biocell.2023.023567 - 26 September 2022

Abstract Yes-associated protein 1 (YAP1) is a downstream effector of the Hippo signaling pathway, and it is involved in tumorigenesis, tissue repair, growth, and development. In this review, the biological roles and the mechanisms of YAP1 in mediating stem cell fate decisions are discussed, including cell proliferation, differentiation, and apoptosis. In general, YAP1 promotes the proliferation and differentiation of stem cells, including embryonic stem cells and adult stem cells. It inhibits apoptosis by binding to the transcription factors, e.g., transcriptional enhanced associate domain (TEAD), Smad, runt-related transcription factor 1/2, p73, p63, and Erb84, to maintain tissue More >

Nora Elizondo-Villarreal^1,*, Luz H. Verástegui-Dominguez¹, Jose J. Quijano-Briones¹, Francisco J. Vázquez-Rodríguez², Eden Rodríguez-Castellanos³, Enrique López-Cuellar³, Ernesto Torres-Lopez¹, Victor M. Castaño-Meneses^4,*

Journal of Renewable Materials, Vol.10, No.12, pp. 3559-3572, 2022, DOI:10.32604/jrm.2022.021945 - 14 July 2022

Abstract

Agave salmiana ash and poultry eggshell powder as CaO sources were used for obtaining nanostructured hydroxyapatite (HAP). The synthesis was carried out by the Green Chemistry Hydrothermal Biosynthesis at 180°C with a pH of 5, by reacting CaO from Agave Salmiana ash and Eggshell powder, with dibasic calcium phosphate (CaHPO₄•2H₂O) in an aqueous solution, with Aloe barbadensis extract. The product was characterized by X-ray diffraction, Fourier-transform infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM). The size and shape of the hydroxyapatite particles changed dramatically in the presence of Aloe barbadensis. Large crystals of Hydroxyapatite were observed

… More > Graphic Abstract