Yoshiro Kato*, Yoshikazu Naiki†, Takayuki Komatsu†, Kazuko Takahashi†, Jiro Nakamura*, Naoki Koide†
Oncology Research, Vol.25, No.4, pp. 479-483, 2017, DOI:10.3727/096504016X14721731148893
Abstract A Wnt agonist, 2-amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl) pyrimidine, is a cellpermeable pyrimidine compound that has been shown to mimic the effect of Wnt. In this study, leukemic mouse
cell lines, RAW 264.7 and J774.1, were incubated with the Wnt agonist. The Wnt agonist showed cell death
in the concentration of 1–10 mM. The Wnt agonist did not show inhibition of GSK-3β activity but induced
β-catenin accumulation in the nucleus. The Wnt agonist showed caspase-independent cell death, but no further
involvement in cell death ER stress signaling. Here we discuss the possible mechanism of Wnt agonist-induced
apoptotic cell death More >
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