Jifu Song, Zhibin Guan, Maojiang Li, Sha Sha, Chao Song, Zhiwei Gao, Yongli Zhao
Oncology Research, Vol.26, No.6, pp. 847-856, 2018, DOI:10.3727/096504017X15016337254632
Abstract MicroRNAs (miRNAs) have emerged as pivotal regulators of the development and progression of gastric
cancer. Studies have shown that miR-154 is a novel cancer-associated miRNA involved in various cancers.
However, the role of miR-154 in gastric cancer remains unknown. Here we aimed to investigate the biological
function and the potential molecular mechanism of miR-154 in gastric cancer. We found that miR-154 was significantly downregulated in gastric cancer tissues and cell lines. The overexpression of miR-154 significantly
repressed the growth and invasion of gastric cancer cells. Bioinformatics analysis and Dual-Luciferase Reporter
Assay data showed that miR-154… More >
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