Manal El-Hamamsy*, Hesham Elwakil†, Amr S. Saad†, May A. Shawki*
Oncology Research, Vol.24, No.6, pp. 521-528, 2016, DOI:10.3727/096504016X14719078133528
Abstract Statins have been reported to have a potential radiosensitizing effect that has not been evaluated in clinical
trials. The aim of this study was to evaluate the efficacy and safety of simvastatin in addition to whole-brain
radiation therapy (WBRT) in patients with brain metastases (BM). A prospective randomized, controlled,
open-label pilot study was conducted on 50 Egyptian patients with BM who were randomly assigned to
receive 30-Gy WBRT (control group: 25 patients) or 30 Gy WBRT+ simvastatin 80 mg/day for the WBRT
period (simvastatin group: 25 patients). The primary outcome was radiological response at 4… More >
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