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    ARTICLE

    White Matter Lesions in Young-Middle Aged Migraineurs with Patent Foreman Ovale: A Case-Control Study

    Yang Hua#, Jinyu Sun#, Yuxuan Lou, Hao Zhang, Jing Shi*, Wei Sun*

    Congenital Heart Disease, Vol.19, No.3, pp. 279-291, 2024, DOI:10.32604/chd.2024.051190 - 26 July 2024

    Abstract Background: White matter lesion (WML) is common in aging brain and is associated with cognitive impairment and dementia. However, recent studies reported an association between patent foramen ovale (PFO) and WML in migraineurs, especially in young, middle-aged migraineurs. Our retrospective, case-control study aims to describe the clinical characteristics of WML in this population and to explore potential risk factors. Methods: 226 patients with migraine and PFO were consecutively initially screened. Relevant factors were selected by the least absolute shrinkage and selection operator (LASSO) regression and multivariable logistic regression model. A Nomogram was employed to visualize… More >

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