SHIMING YE1,2,#, YUFENG ZHANG3,#, TING LIU4, CONG WANG3, ZHENG YAN5, WANDONG SHE2,*, HAIBING HUA4,*
BIOCELL, Vol.47, No.9, pp. 1947-1964, 2023, DOI:10.32604/biocell.2023.029333
- 28 September 2023
Abstract Background: Despite its widespread therapeutic use and effectiveness, the underlying pharmacologic
mechanisms of Wendan decoction (WDD) and how it works to treat sudden deafness (SD) remain unclear. In this
study, the pharmacological mechanisms of WDD underlying SD were analyzed using network pharmacology and
molecular docking. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis
Platform (TCMSP) was employed to identify the active compounds and target genes of WDD, and genes associated
with SD were screened on five databases. RGUI conducted Gene Ontology (GO) functional and the Kyoto
Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. A… More >
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