Pihua Han*†1, Haiming Yang‡1, Xiang Li*1, Jie Wu*, Peili Wang§, Dapeng Liu*, Guodong Xiao¶, Xin Sun*, Hong Ren*
Oncology Research, Vol.28, No.7-8, pp. 715-729, 2020, DOI:10.3727/096504020X16037124605559
Abstract The aim of this study was to identify a novel cancer stemness-related ceRNA regulatory axis in lung adenocarcinoma (LUAD) via weighted gene coexpression network analysis of a stemness index. The RNA sequencing
expression profiles of 513 cancer samples and 60 normal samples were obtained from the TCGA database.
Differentially expressed mRNAs (DEmRNAs), lncRNAs (DElncRNAs), and miRNAs (DEmiRNAs) were
identified with R software. Functional enrichment analysis was conducted using DAVID 6.8. The ceRNA
network was constructed via multiple bioinformatics analyses, and the correlations between possible ceRNAs
and prognosis were analyzed using Kaplan–Meier plots. WGCNA was then… More >
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