Peng Xiao¹, Qi Zhong², Jingxue Chen¹, Dongyuan Wu¹, Zhen Qin¹, Erqiang Zhou^1,*

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4703-4724, 2024, DOI:10.32604/cmc.2024.049791

Abstract In the intelligent medical diagnosis area, Artificial Intelligence (AI)’s trustworthiness, reliability, and interpretability are critical, especially in cancer diagnosis. Traditional neural networks, while excellent at processing natural images, often lack interpretability and adaptability when processing high-resolution digital pathological images. This limitation is particularly evident in pathological diagnosis, which is the gold standard of cancer diagnosis and relies on a pathologist’s careful examination and analysis of digital pathological slides to identify the features and progression of the disease. Therefore, the integration of interpretable AI into smart medical diagnosis is not only an inevitable technological trend but… More >

Manal El-Hamamsy^*, Hesham Elwakil^†, Amr S. Saad^†, May A. Shawki^*

Oncology Research, Vol.24, No.6, pp. 521-528, 2016, DOI:10.3727/096504016X14719078133528

Abstract Statins have been reported to have a potential radiosensitizing effect that has not been evaluated in clinical trials. The aim of this study was to evaluate the efficacy and safety of simvastatin in addition to whole-brain radiation therapy (WBRT) in patients with brain metastases (BM). A prospective randomized, controlled, open-label pilot study was conducted on 50 Egyptian patients with BM who were randomly assigned to receive 30-Gy WBRT (control group: 25 patients) or 30 Gy WBRT+ simvastatin 80 mg/day for the WBRT period (simvastatin group: 25 patients). The primary outcome was radiological response at 4… More >

Shoukun Xu¹, Lujun Zhang¹, Guangqi Jiang¹, Yining Hua², Yi Liu^1,*

CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3021-3039, 2024, DOI:10.32604/cmc.2023.045853

Abstract This paper focuses on the task of few-shot 3D point cloud semantic segmentation. Despite some progress, this task still encounters many issues due to the insufficient samples given, e.g., incomplete object segmentation and inaccurate semantic discrimination. To tackle these issues, we first leverage part-whole relationships into the task of 3D point cloud semantic segmentation to capture semantic integrity, which is empowered by the dynamic capsule routing with the module of 3D Capsule Networks (CapsNets) in the embedding network. Concretely, the dynamic routing amalgamates geometric information of the 3D point cloud data to construct higher-level feature… More >

Michael A. Rebolledo^1,*, Jane S. Yao², Jason N. Johnson¹, Umar S. Boston³, Benjamin R. Waller III¹

Congenital Heart Disease, Vol.19, No.1, pp. 65-68, 2024, DOI:10.32604/chd.2024.046638

Abstract We describe a 63-year-old male who appears to have undergone an early form of the arterial switch operation for D-transposition of the great arteries performed in the mid-1960s. We review the clinical and imaging data that support our conclusion. He had a diagnostic cardiac catheterization which demonstrated severe pulmonary hypertension responsive to epoprostenol and oxygen. Our case may represent one example of the experimental surgical work done prior to Dr. Adibe Jatene’s description of the first successful arterial switch performed in 1975. More >

Yuxin Wang^1,2,*, Jia Shi^1,2

International Journal of Mental Health Promotion, Vol.26, No.1, pp. 69-80, 2024, DOI:10.32604/ijmhp.2023.044641

Abstract In the 21st century, the rapid growth of the Internet has presented a significant avenue for China to respond actively to the aging population and promote the “Healthy China” strategy in an orderly manner. This study uses panel data from the China Health and Retirement Longitudinal Study (CHARLS) to empirically investigate the influence of Internet use on the mental health of older adults, particularly those who lack intergenerational emotional support and suffer from chronic diseases. This study employs a multi-period difference-in-differences (DID) method and a two-stage instrumental variable approach to address the endogenous problem. Results… More >

Jialing Miao¹, Wei Liao^2,*, Baoguo Xie³

International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1147-1157, 2023, DOI:10.32604/ijmhp.2023.030671

Abstract Although employers believe that encouraging and supporting physical exercise activities by purchasing fitness equipment and building sports venues can improve employees’ well-being, the utilization rate is rather low. Since most of the evidence of the well-being promotion in the workplace concentrated on the perspectives of organizational factors and psychosocial factors and focused on the reduction of the negative affect of well-being, it is still an open question whether physical exercise has benefits on both negative and positive affect of wellbeing and who benefits more from physical exercise. Thus, the purpose of this study is to… More >

Wenbin Wang^*, Yang Cao

International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1127-1136, 2023, DOI:10.32604/ijmhp.2023.030315

Abstract How does psychological distress evolve over time? This study utilizes cross-sectional data from the China General Social Survey from 2010 to 2017 to explore the differences in psychological distress among Chinese residents at various ages, periods, and cohorts. The dummy variable method and random effects hierarchical age-period-cohort model were employed to isolate the age, period, and cohort effects that impacted the psychological distress of Chinese urban residents. First, in terms of the age effect, the psychological distress experienced by residents tends to increase initially and then decrease with age. Middle-aged individuals, around 40 years old,… More >

SUNG HEE LIM^1,#, HEE JIN CHO^1,2,3,#, KYOUNG-MEE KIM⁴, HO YEONG LIM¹, WON KI KANG¹, JEEYUN LEE¹, YOUNG SUK PARK¹, HEE CHEOL KIM^5,*, SEUNG TAE KIM^1,*

Oncology Research, Vol.31, No.6, pp. 855-866, 2023, DOI:10.32604/or.2023.030374

Abstract Background: Although bevacizumab is an important treatment for metastatic colorectal cancer (CRC), not all patients with CRC benefit from it; in unselected patient populations, only modest survival benefits have been reported. Methods: We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identify biomarkers for a response to bevacizumab-containing treatment. The molecular analysis comprised whole-exome sequencing, ribonucleic acid sequencing, and a methylation array on patient tissues. Results: Genomic and molecular characterization was successfully conducted in 103 patients. Six of 103 CRC samples were hypermutated, and none of the non-hypermutant tumors were microsatellite unstable. Among… More >

XIAO-JUN ZHOU^1,*, YU-WEI TIAN¹, RUI-HAN LI²

BIOCELL, Vol.47, No.8, pp. 1907-1913, 2023, DOI:10.32604/biocell.2023.030191

Abstract Background: Acer griseum Pax is an endangered species endemic to China with both ornamental and economic value. However, the lack of information on its genome size and characteristics hinders further work at the genome level. Methods: This paper applied bioinformatics methods to predict the characteristics and patterns of the A. griseum genome, providing an important basis for formulating its whole-genome sequencing scheme. This study also characterized the simple sequence repeats (SSRs) of A. griseum, laying the foundation for the development and application of genome-wide SSR markers. In this study, PE150 sequencing was performed by the BGI MGISEQ platform,… More >

Ingo Paetsch^1,*, Roman Gebauer², Christian Paech², Frank-Thomas Riede², Sabrina Oebel¹, Andreas Bollmann¹, Christian Stehning³, Jouke Smink⁴, Ingo Daehnert², Cosima Jahnke¹

Congenital Heart Disease, Vol.18, No.3, pp. 279-294, 2023, DOI:10.32604/chd.2023.029634

Abstract Background: In congenital heart disease (CHD) patients, detailed three-dimensional anatomy depiction plays a pivotal role for diagnosis and therapeutical decision making. Hence, the present study investigated the applicability of an advanced cardiovascular magnetic resonance (CMR) whole heart imaging approach utilizing nonselective excitation and compressed sensing for anatomical assessment and interventional guidance of CHD patients in comparison to conventional dynamic CMR angiography. Methods: 86 consecutive pediatric patients and adults with congenital heart disease (age, 1 to 74 years; mean, 35 years) underwent CMR imaging including a free-breathing, ECG-triggered 3D nonselective SSFP whole heart acquisition using compressed… More >