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  • Open Access

    ARTICLE

    Neural Wiskott-Aldrich syndrome protein (N-WASP) promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

    HYUNG SUN KIM1,#, YUN SUN LEE2,#, SEUNG MYUNG DONG3, HYO JUNG KIM1, DA EUN LEE2, HYEON WOONG KANG2, MYEONG JIN KIM2, JOON SEONG PARK1,*

    Oncology Research, Vol.32, No.4, pp. 615-624, 2024, DOI:10.32604/or.2024.044029

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid malignancies. A specific mechanism of its metastasis has not been established. In this study, we investigated whether Neural Wiskott-Aldrich syndrome protein (N-WASP) plays a role in distant metastasis of PDAC. We found that N-WASP is markedly expressed in clinical patients with PDAC. Clinical analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group. N-WASP was noted to be a novel mediator of epithelial-mesenchymal transition (EMT) via gene expression profile studies. Knockdown of N-WASP in pancreatic cancer cells significantly inhibited cell invasion, migration,… More > Graphic Abstract

    Neural Wiskott-Aldrich syndrome protein (N-WASP) promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

  • Open Access

    ARTICLE

    Wind Energy Data Analysis and Resource Mapping of Dangla, Gojjam, Ethiopia

    Belayneh Yitayew1,*, Wondwossen Bogale2

    Energy Engineering, Vol.119, No.6, pp. 2513-2532, 2022, DOI:10.32604/ee.2022.018961

    Abstract Energy is one of the most important factors in socio-economic development. The rapid increase in energy demand and air pollution has increased the number of ways to generate energy in the power sector. Currently, wind energy capacity in Ethiopia is estimated at 10,000 MW. Of these, however, only eight percent of its capacity has been used in recent years. One of the reasons for the low use of wind energy is the lack of accurate wind atlases in the country. Therefore, the purpose of this study is to develop an accurate wind atlas and review the wind resources using Wind… More >

  • Open Access

    ARTICLE

    Fuzzy MCDM Model for Selection of Infectious Waste Management Contractors

    Nguyen Van Thanh1, Nguyen Hoang Hai1,*, Nguyen Thi Kim Lan2

    CMC-Computers, Materials & Continua, Vol.72, No.2, pp. 2191-2202, 2022, DOI:10.32604/cmc.2022.026357

    Abstract Healthcare supply chains are under pressure to drive down costs because of digital business, shifting customer needs and new competition. Medical waste generated from medical facilities includes medical activities and daily-life activities of patients and their family members. According to statistics of the Department of Health Environmental Management, Vietnam currently has more than 13,500 medical facilities, including hospitals from central to provincial and district levels and private hospitals and medical facilities. Preventive medicine generates about 590 tons of medical waste/day and is estimated to be about 800 tons/day. Medical waste includes ordinary medical waste and hazardous medical waste; in which… More >

  • Open Access

    ARTICLE

    Supplier Selection Fuzzy Model in Supply Chain Management: Vietnamese Cafe Industry Case

    Chia-Nan Wang1, Hoang Tuyet Nhi Thai1,*, Nguyen Van Thanh2

    CMC-Computers, Materials & Continua, Vol.72, No.2, pp. 2291-2304, 2022, DOI:10.32604/cmc.2022.025477

    Abstract Supplier selection is a vital part of the supply chain and is also a current issue that concerns businesses today as supplier quality directly affects the operations of the organization. Choosing the right supplier can help businesses increase productivity, competitiveness in the market, and profits without having to lower the quality of the products. However, choosing a supplier is not a simple matter, it requires businesses to consider many aspects about their suppliers. Therefore, the goal of this study is to propose an integrated model consisting of two models: Fuzzy Analytics Network Process (Fuzzy-ANP) model and Weighted Aggregated Sum Product… More >

  • Open Access

    ARTICLE

    Spherical Fuzzy WASPAS-based Entropy Objective Weighting for International Payment Method Selection

    Phi-Hung Nguyen1,2,*, Thanh-Tuan Dang3, Kim-Anh Nguyen1, Hong-Anh Pham1

    CMC-Computers, Materials & Continua, Vol.72, No.1, pp. 2055-2075, 2022, DOI:10.32604/cmc.2022.025532

    Abstract In international trade, exporters prefer to receive payments as quickly as possible, and importers want to make payments as late as possible. In this respect, the payment field, an essential condition for trade transactions, also represents the positions of exporters and importers conflict. In addition, there are many cases in which various variables must be considered rather than only one specific variable representatively affecting payment, particularly in the case of import-export Small and Medium-Sized Enterprises (SMEs) from emerging countries. A selection of proper payment methods can be categorized as a Multi-Criteria Decision-Making (MCDM) issue. Therefore, this study aims to propose… More >

  • Open Access

    ARTICLE

    Regulation Relatedness Map Creation Method with Latent Semantic Analysis

    Mehmet Murat Huyut1,*, Batuhan Kocaoğlu2, Ünzile Meram3

    CMC-Computers, Materials & Continua, Vol.72, No.1, pp. 2093-2107, 2022, DOI:10.32604/cmc.2022.024190

    Abstract Regulatory authorities create a lot of legislation that must be followed. These create complex compliance requirements and time-consuming processes to find regulatory non-compliance. While the regulations establish rules in the relevant areas, recommendations and best practices for compliance are not generally mentioned. Best practices are often used to find a solution to this problem. There are numerous governance, management, and security frameworks in Information Technology (IT) area to guide businesses to run their processes at a much more mature level. Best practice maps can used to map another best practice, and users can adapt themselves by the help of this… More >

  • Open Access

    ARTICLE

    Ultrastructural analysis of sperm from the genus Idarnes (Hymenoptera: Chalcidoidea, Sycophaginae)

    KHESLLER PATRÍCIA OLAZIA1,2, JULIANA SOUZA DA SILVA1, GUILHERME SIRIMARCO DE SOUZA TONELLI1, SÔNIA NAIR BÁO1,*

    BIOCELL, Vol.46, No.1, pp. 275-283, 2022, DOI:10.32604/biocell.2022.016603

    Abstract In this study, the sperm ultrastructure of three species of Idarnes genus was investigated using light and transmission electron microscopy. Spermatozoon morphology of the three species was similar to that of most Chalcidoidea, with helicoidally twisted nucleus and flagellum. The head region consists of an acrosome and a nucleus; the nucleus-flagellum transition region characterized by the presence of mitochondrial derivatives and the centriolar adjunct; a flagellum region, which includes the axoneme with microtubular arrangement 9 + 9 + 2 and two mitochondrial derivatives. However, the sperm of these three species exhibit features that discriminate one species from each other: (1)… More >

  • Open Access

    ARTICLE

    Transcriptome profile analysis of the accompanying migratory parasitic wasp Aenasius bambawalei (= Aenasius arizonensis girault) (Hymenoptera: Encyrtidae): Genes related to fertilization involved at different stage of ovary development

    JUAN ZHANG2, JUN HUANG3, YAYUAN TANG2, XIUZHEN LONG1

    BIOCELL, Vol.46, No.1, pp. 195-205, 2022, DOI:10.32604/biocell.2022.016563

    Abstract Age-related declines in fertilization success have been reported for a wide range of species. The fertilization of parasitic wasps is closely related to egg production and sperm storage. Aenasius bambawalei (Hymenoptera: Encyridae) is a key parasitic wasp of the important invasive mealybug Phenacoccus solenopsis (Hemiptera: Pseudococcidae). The female offspring ratio of this parasitic wasp was declined with parental age in mass rearing under laboratory conditions. To investigate the molecular mechanisms involved in the reproduction of A. bambawalei, an extensive analysis of the impact of age on transcriptome profile of mated ovaries of this wasp was performed by comparing the gene… More >

  • Open Access

    ARTICLE

    Optimization Model for Selecting Temporary Hospital Locations During COVID-19 Pandemic

    Chia-Nan Wang1, Chien-Chang Chou2,*, Hsien-Pin Hsu3, Van Thanh Nguyen4, Viet Tinh Nguyen4

    CMC-Computers, Materials & Continua, Vol.70, No.1, pp. 397-412, 2022, DOI:10.32604/cmc.2022.019470

    Abstract The two main approaches that countries are using to ease the strain on healthcare infrastructure is building temporary hospitals that are specialized in treating COVID-19 patients and promoting preventive measures. As such, the selection of the optimal location for a temporary hospital and the calculation of the prioritization of preventive measures are two of the most critical decisions during the pandemic, especially in densely populated areas where the risk of transmission of the virus is highest. If the location selection process or the prioritization of measures is poor, healthcare workers and patients can be harmed, and unnecessary costs may come… More >

  • Open Access

    ARTICLE

    Benchmarking Approach to Compare Web Applications Static Analysis Tools Detecting OWASP Top Ten Security Vulnerabilities

    Juan R. Bermejo Higuera1, *, Javier Bermejo Higuera1, Juan A. Sicilia Montalvo1, Javier Cubo Villalba1, Juan José Nombela Pérez1

    CMC-Computers, Materials & Continua, Vol.64, No.3, pp. 1555-1577, 2020, DOI:10.32604/cmc.2020.010885

    Abstract To detect security vulnerabilities in a web application, the security analyst must choose the best performance Security Analysis Static Tool (SAST) in terms of discovering the greatest number of security vulnerabilities as possible. To compare static analysis tools for web applications, an adapted benchmark to the vulnerability categories included in the known standard Open Web Application Security Project (OWASP) Top Ten project is required. The information of the security effectiveness of a commercial static analysis tool is not usually a publicly accessible research and the state of the art on static security tool analyzers shows that the different design and… More >

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