Xuexin Gao*, Xuezhen Gao†, Chao Li*, Yukun Zhang*, Lei Gao‡
Oncology Research, Vol.24, No.5, pp. 337-343, 2016, DOI:10.3727/096504016X14666990347671
Abstract Lung cancer remains a critical health concern worldwide. Long noncoding RNAs with ultraconserved elements have recently been implicated in human tumorigenesis. The present study investigated the role of ultraconserved element 338 (uc.338) in the regulation of cell proliferation and metastasis in human lung cancer.
Our data showed that the expression of uc.338 in lung cancer was remarkably increased in vivo and in vitro.
Depletion of uc.338 with specific siRNA interference retarded the cell proliferative rate in lung cancer cell
lines NCI-H929 and H1688. Furthermore, knockdown of uc.338 caused cell cycle arrest in the G0/G1 phase in More >
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