Hasan J. Alyamani^*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 1129-1142, 2024, DOI:10.32604/cmes.2024.047756 - 16 April 2024

Abstract The evaluation of disease severity through endoscopy is pivotal in managing patients with ulcerative colitis, a condition with significant clinical implications. However, endoscopic assessment is susceptible to inherent variations, both within and between observers, compromising the reliability of individual evaluations. This study addresses this challenge by harnessing deep learning to develop a robust model capable of discerning discrete levels of endoscopic disease severity. To initiate this endeavor, a multi-faceted approach is embarked upon. The dataset is meticulously preprocessed, enhancing the quality and discriminative features of the images through contrast limited adaptive histogram equalization (CLAHE). A More > Graphic Abstract

AMYLLY SANUELLY DA PAZ MARTINS^1,#, MARLA DE CERQUEIRA ALVES^2,#, ORLANDO ROBERTO PIMENTEL DE ARAÚJO³, FABIANA OLIVEIRA DOS SANTOS CAMATARI⁴, MARÍLIA OLIVEIRA FONSECA GOULART^1,3,5, FABIANA ANDRÉA MOURA^2,6,*

BIOCELL, Vol.47, No.11, pp. 2547-2566, 2023, DOI:10.32604/biocell.2023.043253 - 27 November 2023

Abstract

Curcumin, a natural product, has exhibited promising effects in both animal models and clinical trials, interacting with a multitude of factors linked to Inflammatory Bowel Disease (IBD). These factors encompass cytokines, oxidative stress-associated enzymes, and modulation of the intestinal microbiota. Notably, curcumin has demonstrated therapeutic potential in animal models of colitis, wherein it exerts a negative regulatory influence on pivotal signaling pathways such as PI3/Akt, JAK/STAT, and β-catenin. Moreover, it inhibits the expression of pro-inflammatory enzymes and co-stimulatory molecules (including RANKL, ICAM-1, CD205, CD256, TLR4, among others), while curbing immune cell chemotaxis, thereby attenuating the characteristic

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CHENHAO SHI¹, MAOHONG HUA², GUANHUA XU^3,*

BIOCELL, Vol.47, No.6, pp. 1329-1344, 2023, DOI:10.32604/biocell.2023.028381 - 19 May 2023

Abstract Background: Ulcerative colitis (UC) is a chronic disease that often presents with abdominal pain, diarrhea, hematochezia, and significant morbidity. Gancao Xiexin decoction (GXD), a traditional Chinese medicine, has been applied for the clinical treatment of UC, while its action mechanisms are unclear. Methods: The active ingredients and their targets of GXD, and UC-related targets, were derived from public databases. Protein-protein interaction, Gene Ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to analyze the important active compounds, key targets, and signaling pathways. Then, molecular docking and animal experiments were performed to verify… More >

MARLA DE CERQUEIRA ALVES¹, MONISE OLIVEIRA SANTOS¹, NASSIB BEZERRA BUENO¹, ORLANDO ROBERTO PIMENTEL DE ARAÚJO², MARÍLIA OLIVEIRA FONSECA GOULART^2,3,4, FABIANA ANDRÉA MOURA^1,5,*

BIOCELL, Vol.46, No.9, pp. 2015-2047, 2022, DOI:10.32604/biocell.2022.020407 - 18 May 2022

Abstract

The roots of the vegetal Curcuma due to its high content of polyphenols, has been used successfully in several clinical situations. This review assessed the effect of curcumin/Curcuma longa on symptoms and metabolic changes in inflammatory bowel disease (IBD). A systematic review of animal models and randomized clinical trials (RCTs) was conducted by searching the following electronic databases: PubMed, CENTRAL, LILACS, Science Direct, and ClinicalTrials.gov. From 997 found records, 62 were included. More than 90% of the animal studies reported an improvement in macroscopic, histologic and/or functional activity; 80% identified decreased oxidative and/or inflammatory biomarkers in

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AMYLLY SANUELLY DA PAZ MARTINS¹, SAMARA BOMFIM GOMES CAMPOS², MARÍLIA OLIVEIRA FONSECA GOULART^1,2,3, FABIANA ANDRÉA MOURA^4,*

BIOCELL, Vol.45, No.3, pp. 461-481, 2021, DOI:10.32604/biocell.2021.014332 - 03 March 2021

Abstract Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, has a not yet completely defined aetiology and is characterized by a progressive chronic inflammation that involves nitroxidative stress and dysbiosis. Extraintestinal manifestations can occur and affect several organs, including the liver and bile ducts, joints, skin, eyes, and less frequently, the heart, brain, and kidneys, increasing the risk of morbidity and mortality. These repercussions may be associated with the activity or severity of IBD. The present review proposes to report and analyse the participation of dysbiosis and nitroxidative stress in the genesis of More >

Dorota Mańkowska-Wierzbicka, Ewelina Swora-Cwynar, Barbara Poniedziałek, Zygmunt Adamski, Agnieszka Dobrowolska, Jacek Karczewski

European Cytokine Network, Vol.26, No.2, pp. 26-37, 2015, DOI:10.1684/ecn.2015.0363

Abstract Introduction: This study aimed to compare the accuracy of selected laboratory markers in assessing disease activity in patients with ulcerative colitis (UC). The analysis included serum IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α, IFN-γ, hsCRP, peripheral regulatory T cells, as well as fecal calprotectin and lactoferrin. Patients and methods: A group of 45 adults with UC was enrolled in the study. Disease activity was assessed using the Mayo endoscopic index, while for clinical activity scoring, the Clinical Activity Index (CAI) was used. Concentrations of markers investigated were estimated by means of flow cytometry and enzyme-linked immunosorbent… More >

Ravi Verma^a, Nirmal Verma^a, Jaishree Paul

European Cytokine Network, Vol.24, No.3, pp. 130-138, 2013, DOI:10.1684/ecn.2013.0343

Abstract Background: Ulcerative colitis (UC) is a chronic inflammatory disorder of the gastrointestinal tract involving aberrant activation of innate and adaptive immune responses. We aimed to study the expression profiles of the susceptibility gene Nod1 and selected pro- and anti- inflammatory cytokines during different stages of UC. Methods: 65 patients with mild, severe or remission stage of UC, and 22 normal colon mucosal biopsies from control individuals were included in the study for measuring the expression of nucleotide binding oligomerization 1(Nod1) and related pro- and anti-inflammatory cytokines using quantitative reverse transcription-PCR (qRT-PCR). mRNA expression levels were… More >

Caroll J. Beltrán^1,2*, Enzo Candia^1*, Benjamín Erranz¹, Carolina Figueroa³, Maria J. Gonzalez⁴, Rodrigo Quera^3,5, Marcela A. Hermoso¹

European Cytokine Network, Vol.20, No.1, pp. 33-38, 2009, DOI:10.1684/ecn.2009.0142

Abstract Crohn’s disease (CD) and ulcerative colitis (UC) belong to the group of inflammatory bowel dis-eases (IBD), with complex ethiopathogenic factors that include an unbalanced immune and inflammatory response to commensal and food antigens. The differential diagnosis between CD and UC is performed using clinical, endoscopic, histopathological, serological and radiological methods; however between 10-15% of IBD patients are diagnosed as “unclassified colitis”. Further research into IBD is necessary in order to develop addi-tional diagnostic tools. The aim of this work was to see if the Th1, Th17 or Th2 immune pattern, represented by CD4+ lymphocytes producing… More >

Caroll J. Beltrán^1,2, Enzo Candia¹, Benjamín Erranz¹, Carolina Figueroa³, Maria J. Gonzalez⁴, Rodrigo Quera^3,5, Marcela A. Hermoso¹

European Cytokine Network, Vol.20, No.2, pp. 94-94, 2009, DOI:10.1684/ecn.2009.0151

Abstract This article has no abstract. More >