LINNA TAN1,2, YUYONG TAN1,2, DELIANG LIU1,2,*
BIOCELL, Vol.44, No.4, pp. 535-543, 2020, DOI:10.32604/biocell.2020.09171
- 24 December 2020
Abstract ULK1 (unc-51 like autophagy activating kinase 1), a mammalian serine/threonine kinase, is a key component of
autophagy initiation complex and helps to induce all types of autophagy. Canonical autophagy is a process in which,
through the interactions of a series of autophagy-related proteins, damaged organelles or misfolded proteins are
engulfed by autophagosomes and then merged with lysosomes to be degraded. Thus, canonical autophagy is an
important constituent part of the cellular “quality control.” Besides, accumulating evidence indicates that ULK1 exerts
autophagy-independent effects in a cell-specific manner. For example, ULK1 facilitates neurite elongation through the
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