Dengfeng Zhang1, Feng Jiang1, Xiao Wang, Guojun Li
Oncology Research, Vol.25, No.5, pp. 743-751, 2017, DOI:10.3727/096504016X14772395226335
Abstract Ubiquitin-specific protease 22 (USP22), a novel deubiquitinating enzyme, belongs to an extended family of
proteins that have ubiquitin hydrolase activity. Recently, USP22 has attracted widespread attention because
of its implication in carcinogenesis. However, there have been no studies, to our knowledge, investigating the
expression of USP22 in osteosarcoma (OS) and its association with OS progression. In this study, we explored
the role of USP22 in OS. We demonstrated that USP22 was highly expressed in OS tissue and cell lines.
Downregulation of USP22 inhibited OS cell proliferation, invasion, and epithelial–mesenchymal transition
(EMT) in vitro. In addition, More >
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