Jin Zhang, Danjie Zhang, Liangzhang Sun
Oncology Research, Vol.25, No.2, pp. 249-257, 2017, DOI:10.3727/096504016X693164
Abstract Ubiquitin-specific protease 14 (USP14), one of three proteasome-associated deubiquitinating enzymes (DUBs),
plays an essential role in the development of human carcinoma. However, to the best of our knowledge, the role
of USP14 in esophageal squamous cell carcinoma (ESCC) is unknown. In the current study, we investigated the
expression and role of USP14 in ESCC. Our results showed that the level of USP14 was significantly increased
in ESCC tissues and cell lines. Downregulation of USP14 significantly inhibited ESCC cell proliferation and
ESCC tumor growth in nude mice. Downregulation of USP14 also suppressed the migration/invasion in ESCC More >
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