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  • Open Access

    ARTICLE

    Oleanolic acid inhibits colon cancer cell stemness and reverses chemoresistance by suppressing JAK2/STAT3 signaling pathway

    RUOYU CHEN1, YIMAN WU1, FENG WANG1, JUNTAO ZHOU1, HUAZHANG ZHUANG1, WEI LI2,*

    BIOCELL, Vol.48, No.7, pp. 1037-1046, 2024, DOI:10.32604/biocell.2024.051074

    Abstract Background: Oleanolic acid (OA), a pentacyclic triterpenoid exhibiting specific anti-cancer properties and highly effective antioxidant activity, was isolated from traditional Chinese medicinal herbs. Conversely, the OA that impacts colon cancer (CC) cells and its underlying mechanisms remain poorly understood. Methods: The cytotoxic effect of OA alone or OA-5-Fluorouracil (5-FU) combination on normal and CC cells was analyzed by methyl thiazolyl diphenyl-tetrazolium bromide (MTT). Then, the impact of OA on CC cell lines (LoVo and HT-29) proliferation and stemness were measured using colon formation and tumorsphere formation assays. Octamer-binding transcription factor 4 (Oct4), Prominin-1 (CD133), Nanog,… More >

  • Open Access

    ARTICLE

    miR-557 suppresses hepatocellular carcinoma cell proliferation and migration via downregulating CBX4

    XULONG SUN1,#, WENTAO DING2,#, CHAO JIANG3, ZHIAN FANG4,*

    BIOCELL, Vol.48, No.7, pp. 1071-1079, 2024, DOI:10.32604/biocell.2024.050519

    Abstract Introduction: Hepatocellular carcinoma (HCC), a prevalent malignancy, poses significant challenges with high tumor heterogeneity and poor prognosis. MicroRNAs (miRNAs) play a pivotal role in hepatocarcinogenesis. Although abnormalities in microRNA-557 (miR-557) expression have been implicated in various cancer types, its role in HCC remains unclear. Therefore, there is a need to explore the function of microRNA-557 in HCC. Methods: Candidate miRNAs were identified through screening in GSE108724 and GSE20077. Real-time PCR was employed to analyze the expression level of miR-557 in hepatoma cell lines and tissues. Cell viability and migration assays were applied to assess the… More > Graphic Abstract

    miR-557 suppresses hepatocellular carcinoma cell proliferation and migration via downregulating CBX4

  • Open Access

    REVIEW

    Endophytic Occupation in Nodules of Rhynchosia Plants from Semiarid Regions of Argentina

    Cinthia T. Lucero1, María de los Á. Ruíz2, Fabiola Pagliero1, Carolina Castaño1, Mariela L. Ambrosino1, Graciela S. Lorda1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1081-1099, 2024, DOI:10.32604/phyton.2024.050762

    Abstract Beneficial microbes can improve soil health by promoting soil structure, nutrient cycling, and disease suppression. In addition, a wide array of rhizospheric microbes are responsible for producing metabolically active compounds including various types of plant growth regulators. So, microbial biodiversity studies could contribute to the improvement of agricultural practices in deprived areas, such as the Pampean semiarid region. The vast majority of studies conducted on endophytic microorganisms have focused on intensive crop legume species. In contrast, little attention has been paid to microorganisms of native legumes, whose ecology is not directly affected by human action.… More >

  • Open Access

    ARTICLE

    Transient Analysis of a Reactor Coolant Pump Rotor Seizure Nuclear Accident

    Mengdong An1, Weiyuan Zhong1, Wei Xu2, Xiuli Wang1,*

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1331-1349, 2024, DOI:10.32604/fdmp.2023.046604

    Abstract The reactor coolant pump (RCP) rotor seizure accident is defined as a short-time seizure of the RCP rotor. This event typically leads to an abrupt flow decrease in the corresponding loop and an ensuing reactor and turbine trip. The significant reduction of core coolant flow while the reactor is being operated at full load can have very negative consequences. This potentially dangerous event is typically characterized by a complex transient behavior in terms of flow conditions and energy transformation, which need to be analyzed and understood. This study constructed transient flow and rotational speed mathematical More > Graphic Abstract

    Transient Analysis of a Reactor Coolant Pump Rotor Seizure Nuclear Accident

  • Open Access

    ARTICLE

    An Investigation into the Performances of Cement Mortar Incorporating Superabsorbent Polymer Synthesized with Kaolin

    Xiao Huang1,2, Jin Yang3,*

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1393-1406, 2024, DOI:10.32604/fdmp.2024.046360

    Abstract Cement-based materials are fundamental in the construction industry, and enhancing their properties is an ongoing challenge. The use of superabsorbent polymers (SAP) has gained significant attention as a possible way to improve the performance of cement-based materials due to their unique water-absorption and retention properties. This study investigates the multifaceted impact of kaolin intercalation-modified superabsorbent polymers (K-SAP) on the properties of cement mortar. The results show that K-SAP significantly affects the cement mortar’s rheological behavior, with distinct phases of water absorption and release, leading to changes in workability over time. Furthermore, K-SAP alters the hydration More >

  • Open Access

    ARTICLE

    Support Vector Machine (SVM) and Object Based Classification in Earth Linear Features Extraction: A Comparison

    Siti Aekbal Salleh1,2,*, Nafisah Khalid1, Natasha Danny6, Nurul Ain Mohd. Zaki2,3, Mustafa Ustuner4, Zulkiflee Abd Latif1,2, Vladimir Foronda5

    Revue Internationale de Géomatique, Vol.33, pp. 183-199, 2024, DOI:10.32604/rig.2024.050723

    Abstract Due to the spectral and spatial properties of pervious and impervious surfaces, image classification and information extraction in detailed, small-scale mapping of urban surface materials is quite difficult and complex. Emerging methods and innovations in image classification have centred on object-based classification techniques and various segmentation techniques, which are fundamental to this approach. Consequently, the purpose of this study is to determine which classification method is most suitable for extracting linear features in terms of techniques and performance by comparing two classification methods, pixel-based approach and object-based approach, using WorldView-2 satellite imagery to specifically highlight… More > Graphic Abstract

    Support Vector Machine (SVM) and Object Based Classification in Earth Linear Features Extraction: A Comparison

  • Open Access

    ARTICLE

    IKIP downregulates THBS1/FAK signaling to suppress migration and invasion by glioblastoma cells

    ZHAOYING ZHU1,#, YANJIA HU2,#, FENG YE2, HAIBO TENG2, GUOLIANG YOU1, YUNHUI ZENG2, MENG TIAN2, JIANGUO XU2, JIN LI2, ZHIYONG LIU2, HAO LIU2,*, NIANDONG ZHENG1,*

    Oncology Research, Vol.32, No.7, pp. 1173-1184, 2024, DOI:10.32604/or.2024.042456

    Abstract Background: Inhibitor of NF-κB kinase-interacting protein (IKIP) is known to promote proliferation of glioblastoma (GBM) cells, but how it affects migration and invasion by those cells is unclear. Methods: We compared levels of IKIP between glioma tissues and normal brain tissue in clinical samples and public databases. We examined the effects of IKIP overexpression and knockdown on the migration and invasion of GBM using transwell and wound healing assays, and we compared the transcriptomes under these different conditions to identify the molecular mechanisms involved. Results: Based on data from our clinical samples and from public databases, More >

  • Open Access

    ARTICLE

    BDPartNet: Feature Decoupling and Reconstruction Fusion Network for Infrared and Visible Image

    Xuejie Wang1, Jianxun Zhang1,*, Ye Tao2, Xiaoli Yuan1, Yifan Guo1

    CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4621-4639, 2024, DOI:10.32604/cmc.2024.051556

    Abstract While single-modal visible light images or infrared images provide limited information, infrared light captures significant thermal radiation data, whereas visible light excels in presenting detailed texture information. Combining images obtained from both modalities allows for leveraging their respective strengths and mitigating individual limitations, resulting in high-quality images with enhanced contrast and rich texture details. Such capabilities hold promising applications in advanced visual tasks including target detection, instance segmentation, military surveillance, pedestrian detection, among others. This paper introduces a novel approach, a dual-branch decomposition fusion network based on AutoEncoder (AE), which decomposes multi-modal features into intensity… More >

  • Open Access

    ARTICLE

    Learning Vector Quantization-Based Fuzzy Rules Oversampling Method

    Jiqiang Chen, Ranran Han, Dongqing Zhang, Litao Ma*

    CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 5067-5082, 2024, DOI:10.32604/cmc.2024.051494

    Abstract Imbalanced datasets are common in practical applications, and oversampling methods using fuzzy rules have been shown to enhance the classification performance of imbalanced data by taking into account the relationship between data attributes. However, the creation of fuzzy rules typically depends on expert knowledge, which may not fully leverage the label information in training data and may be subjective. To address this issue, a novel fuzzy rule oversampling approach is developed based on the learning vector quantization (LVQ) algorithm. In this method, the label information of the training data is utilized to determine the antecedent… More >

  • Open Access

    ARTICLE

    A Dual Domain Robust Reversible Watermarking Algorithm for Frame Grouping Videos Using Scene Smoothness

    Yucheng Liang1,2,*, Ke Niu1,2,*, Yingnan Zhang1,2, Yifei Meng1,2

    CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 5143-5174, 2024, DOI:10.32604/cmc.2024.051364

    Abstract The proposed robust reversible watermarking algorithm addresses the compatibility challenges between robustness and reversibility in existing video watermarking techniques by leveraging scene smoothness for frame grouping videos. Grounded in the H.264 video coding standard, the algorithm first employs traditional robust watermark stitching technology to embed watermark information in the low-frequency coefficient domain of the U channel. Subsequently, it utilizes histogram migration techniques in the high-frequency coefficient domain of the U channel to embed auxiliary information, enabling successful watermark extraction and lossless recovery of the original video content. Experimental results demonstrate the algorithm’s strong imperceptibility, with… More >

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