THAINá RODRIGUES1,2, PATRíCIA CANDIDO1,3, FERES CAMARGO MALUF1, POLIANA ROMãO1, CAROLINA MIE MIOSHI1, VANESSA RIBEIRO GUIMARãES1, JULIANA ALVES DE CAMARGO1, KARINA SERAFIM DA SILVA1,4, GABRIEL ARANTES DOS SANTOS1, IRAN AMORIM SILVA1, KATIA RAMOS MOREIRA LEITE1, WILLIAM C. NAHAS5, SABRINA T. REIS1,3, RUAN PIMENTA1,6, NAYARA IZABEL VIANA1,7,*
Oncology Research, Vol.33, No.6, pp. 1377-1382, 2025, DOI:10.32604/or.2025.055306
- 29 May 2025
Abstract Objectives: Bladder Cancer (BC) is one of the most commonly diagnosed malignancies worldwide, with high rates of mortality and morbidity. It can be classified as non-muscle invasive bladder cancer (NMIBC) or muscle-invasive bladder cancer (MIBC), with radical cystectomy being the treatment for MIBC, which significantly reduces quality of life. MicroRNAs (miRs) act as critical genetic regulators, with both oncogenic and tumor-suppressive roles. MiR-10a is described as a tumor suppressor in various neoplasms, but its role in BC is controversial. This study aims to assess the activity of miR-10a in cellular invasion and proliferation in two… More >
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