Guoqiang Zhang*1, Zengyan Liu†1, Yong Han*, Xiaohong Wang*, Zhenlin Yang*
Oncology Research, Vol.24, No.4, pp. 233-238, 2016, DOI:10.3727/096504016X14648701447977
Abstract Triple-negative breast cancer (TNBC) is associated with high recurrence rates of metastasis and death. miR-509
has been reported to be a tumor suppressor in many cancers, but its effect in TNBC has not yet been identified. In this article, we explored the effects of miR-509 on the malignant phenotype of TNBC cells, including
proliferation, apoptosis, migration, and invasion. We transiently transfected TNBC cells, Hs578T, with miR-509
mimic. Upon transfection, the expression of miR-509 was upregulated about 50-fold compared with cells
transfected with scramble mimic. Overexpression of miR-509 inhibited cell proliferation, induced cell apoptosis, and suppressed More >
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